mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TNKS
Gene summary
Basic gene Info.Gene symbolTNKS
Gene nametankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
SynonymsARTD5|PARP-5a|PARP5A|PARPL|TIN1|TINF1|TNKS1|pART5
CytomapUCSC genome browser: 8p23.1
Type of geneprotein-coding
RefGenesNM_003747.2,
DescriptionADP-ribosyltransferase diphtheria toxin-like 5TANK1TNKS-1TRF1-interacting ankyrin-related ADP-ribose polymerasepoly [ADP-ribose] polymerase 5Atankyrase Itankyrase-1
Modification date20141215
dbXrefs MIM : 603303
HGNC : HGNC
Ensembl : ENSG00000173273
HPRD : 04490
Vega : OTTHUMG00000090481
ProteinUniProt: O95271
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TNKS
BioGPS: 8658
PathwayNCI Pathway Interaction Database: TNKS
KEGG: TNKS
REACTOME: TNKS
Pathway Commons: TNKS
ContextiHOP: TNKS
ligand binding site mutation search in PubMed: TNKS
UCL Cancer Institute: TNKS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000209protein polyubiquitination19759537
GO:0006471protein ADP-ribosylation21270334
GO:0018105peptidyl-serine phosphorylation17026964
GO:0018107peptidyl-threonine phosphorylation17026964
GO:0032212positive regulation of telomere maintenance via telomerase18221737
GO:0043392negative regulation of DNA binding9822378
GO:0045944positive regulation of transcription from RNA polymerase II promoter19245366
GO:0070212protein poly-ADP-ribosylation9822378
GO:0070213protein auto-ADP-ribosylation19759537


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Ligand binding site mutations for TNKS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C1245R1247GCOAD1
G1206G1206RKIRC1
H1201R1200QLUSC1
M1207M1207RSKCM1
E1291V1293ASTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TNKS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H1201R1200Q-1.7482725
E1291V1293A-1.0525547
G1206G1206R-0.99350252
M1207M1207R-0.61644075
C1245R1247G-0.57291248
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TNKS from PDB

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Differential gene expression and gene-gene network for TNKS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TNKS and the right PPI network was created from samples without mutations in the LBS of TNKS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TNKS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TNKS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TNKS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)2rf5AC1245
ZNZINC(2+)3uddAC1245
ZNZINC(2+)3uddBC1245
ZNZINC(2+)3uh2AC1245
ZNZINC(2+)3uh2BC1245
ZNZINC(2+)3uh4AC1245
ZNZINC(2+)3uh4BC1245
ZNZINC(2+)4dviAC1245
ZNZINC(2+)4dviBC1245
ZNZINC(2+)4i9iAC1245
ZNZINC(2+)4i9iBC1245
ZNZINC(2+)4i9iCC1245
ZNZINC(2+)4i9iDC1245
ZNZINC(2+)4k4eAC1245
ZNZINC(2+)4k4eBC1245
ZNZINC(2+)4k4fAC1245
ZNZINC(2+)4k4fBC1245
ZNZINC(2+)4li6AC1245
ZNZINC(2+)4li6BC1245
ZNZINC(2+)4li8AC1245
ZNZINC(2+)4li8BC1245
ZNZINC(2+)4krsAC1245
ZNZINC(2+)4krsBC1245
ZNZINC(2+)4n3rAC1245
ZNZINC(2+)4n3rBC1245
ZNZINC(2+)4n4vAC1245
ZNZINC(2+)4n4vBC1245
ZNZINC(2+)4msgAC1245
ZNZINC(2+)4msgBC1245
ZNZINC(2+)4mskAC1245
ZNZINC(2+)4mskBC1245
ZNZINC(2+)4mskCC1245
ZNZINC(2+)4mskDC1245
ZNZINC(2+)4mt9AC1245
ZNZINC(2+)4mt9BC1245
ZNZINC(2+)4oa7AC1245
ZNZINC(2+)4oa7BC1245
ZNZINC(2+)4oa7CC1245
ZNZINC(2+)4oa7DC1245
ZNZINC(2+)4w5sAC1245
ZNZINC(2+)4w6eAC1245
ZNZINC(2+)4torAC1245
ZNZINC(2+)4torBC1245
ZNZINC(2+)4torCC1245
ZNZINC(2+)4torDC1245
ZNZINC(2+)4tosAC1245
ZNZINC(2+)4tosBC1245
ZNZINC(2+)4u6aAC1245
ZNZINC(2+)4uuhAC1245
ZNZINC(2+)4uw1AC1245
ZNZINC(2+)4uw1BC1245
ZNZINC(2+)4uw1CC1245
ZNZINC(2+)4uw1DC1245
ZNZINC(2+)4uw1EC1245
ZNZINC(2+)4uw1FC1245
ZNZINC(2+)4uw1GC1245
ZNZINC(2+)4uw1HC1245
ZNZINC(2+)5eceAC1245
ZNZINC(2+)5eceBC1245
ZNZINC(2+)5eceCC1245
ZNZINC(2+)5eceDC1245
XAV2-[4-(TRIFLUOROMETHYL)PHENYL]-7,8-DIHYDRO-5H-THIOPYRANO[4,3-D]PYRIMIDIN-4-OL3uh4AE1291
XAV2-[4-(TRIFLUOROMETHYL)PHENYL]-7,8-DIHYDRO-5H-THIOPYRANO[4,3-D]PYRIMIDIN-4-OL3uh4BE1291
1XON-[(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)METHYL]-3-PHENYL- N-(THIOPHEN-2-YLMETHYL)PROPANAMIDE4li6BE1291
3J18-(HYDROXYMETHYL)-2-[4-(1-METHYL-1H-PYRAZOL-4-YL) PHENYL]QUINAZOLIN-4(3H)-ONE4w5sAE1291
3J52-(4-{6-[(3S)-3,4-DIMETHYLPIPERAZIN-1-YL]-4- METHYLPYRIDIN-3-YL}PHENYL)-8-(HYDROXYMETHYL) QUINAZOLIN-4(3H)-ONE4w6eAE1291
3DN3-(4-{[4-(DIMETHYLAMINO)PIPERIDIN-1-YL]METHYL}PHENYL)- 5-METHYLISOQUINOLIN-1(2H)-ONE4u6aAE1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1AE1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1CE1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1DE1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1GE1291
P34N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE3uh2AG1206 E1291
P34N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE3uh2BG1206 E1291
34M3-(4-METHOXYPHENYL)-5-({[4-(4-METHOXYPHENYL)-5-METHYL-4H-1,2,4-TRIAZOL-3-YL]SULFANYL}METHYL)-1,2,4-OXADIAZOLE3uddAH1201
34M3-(4-METHOXYPHENYL)-5-({[4-(4-METHOXYPHENYL)-5-METHYL-4H-1,2,4-TRIAZOL-3-YL]SULFANYL}METHYL)-1,2,4-OXADIAZOLE3uddBH1201
P34N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE3uh2AH1201
P34N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE3uh2BH1201
2IWIWR-24dviAH1201
2IWIWR-24dviBH1201
K4EN~2~-(5-CHLORO-2-METHOXYPHENYL)-N-[TRANS-4-(2-OXO-2,3- DIHYDRO-1H-BENZIMIDAZOL-1-YL)CYCLOHEXYL]GLYCINAMIDE4k4eAH1201
K4EN~2~-(5-CHLORO-2-METHOXYPHENYL)-N-[TRANS-4-(2-OXO-2,3- DIHYDRO-1H-BENZIMIDAZOL-1-YL)CYCLOHEXYL]GLYCINAMIDE4k4eBH1201
K4F4-[(4S)-5,5-DIMETHYL-2-OXO-4-PHENYL-1,3-OXAZOLIDIN-3- YL]-N-(QUINOLIN-8-YL)BENZAMIDE4k4fAH1201
2GY(4S)-3-{TRANS-4-[6-AMINO-5-(PYRIMIDIN-2-YL)PYRIDIN-3- YL]CYCLOHEXYL}-5,5-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-2- ONE4n4vAH1201
2GY(4S)-3-{TRANS-4-[6-AMINO-5-(PYRIMIDIN-2-YL)PYRIDIN-3- YL]CYCLOHEXYL}-5,5-DIMETHYL-4-PHENYL-1,3-OXAZOLIDIN-2- ONE4n4vBH1201
2XS4-[(3AR,4R,7S,7AS)-1,3-DIOXO-1,3,3A,4,7,7A-HEXAHYDRO- 2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL) BENZAMIDE4oa7AH1201
2XS4-[(3AR,4R,7S,7AS)-1,3-DIOXO-1,3,3A,4,7,7A-HEXAHYDRO- 2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL) BENZAMIDE4oa7CH1201
IW81-[(1-ACETYL-5-BROMO-1H-INDOL-6-YL)SULFONYL]-N-ETHYL-N- (3-METHYLPHENYL)PIPERIDINE-4-CARBOXAMIDE4torAH1201
IW81-[(1-ACETYL-5-BROMO-1H-INDOL-6-YL)SULFONYL]-N-ETHYL-N- (3-METHYLPHENYL)PIPERIDINE-4-CARBOXAMIDE4torBH1201
IW81-[(1-ACETYL-5-BROMO-1H-INDOL-6-YL)SULFONYL]-N-ETHYL-N- (3-METHYLPHENYL)PIPERIDINE-4-CARBOXAMIDE4torCH1201
IW81-[(1-ACETYL-5-BROMO-1H-INDOL-6-YL)SULFONYL]-N-ETHYL-N- (3-METHYLPHENYL)PIPERIDINE-4-CARBOXAMIDE4torDH1201
1DYN-(2-METHOXYPHENYL)-4-{[3-(4-OXO-3,4-DIHYDROQUINAZOLIN- 2-YL)PROPANOYL]AMINO}BENZAMIDE4i9iAH1201 E1291
1DYN-(2-METHOXYPHENYL)-4-{[3-(4-OXO-3,4-DIHYDROQUINAZOLIN- 2-YL)PROPANOYL]AMINO}BENZAMIDE4i9iBH1201 E1291
1DYN-(2-METHOXYPHENYL)-4-{[3-(4-OXO-3,4-DIHYDROQUINAZOLIN- 2-YL)PROPANOYL]AMINO}BENZAMIDE4i9iCH1201 E1291
1DYN-(2-METHOXYPHENYL)-4-{[3-(4-OXO-3,4-DIHYDROQUINAZOLIN- 2-YL)PROPANOYL]AMINO}BENZAMIDE4i9iDH1201 E1291
1XON-[(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)METHYL]-3-PHENYL- N-(THIOPHEN-2-YLMETHYL)PROPANAMIDE4li6AH1201 E1291
1XP4-CHLORO-5-CYANO-N-{2-[4-(4-FLUOROBENZOYL)PIPERIDIN-1- YL]ETHYL}-2-METHOXYBENZAMIDE4li7AH1201 E1291
1XP4-CHLORO-5-CYANO-N-{2-[4-(4-FLUOROBENZOYL)PIPERIDIN-1- YL]ETHYL}-2-METHOXYBENZAMIDE4li7BH1201 E1291
1XQ2-[4-(4-FLUOROBENZOYL)PIPERIDIN-1-YL]-N-[(4-OXO-3,5,7, 8-TETRAHYDRO-4H-PYRANO[4,3-D]PYRIMIDIN-2-YL)METHYL]-N- (THIOPHEN-2-YLMETHYL)ACETAMIDE4li8AH1201 E1291
1XQ2-[4-(4-FLUOROBENZOYL)PIPERIDIN-1-YL]-N-[(4-OXO-3,5,7, 8-TETRAHYDRO-4H-PYRANO[4,3-D]PYRIMIDIN-2-YL)METHYL]-N- (THIOPHEN-2-YLMETHYL)ACETAMIDE4li8BH1201 E1291
2GU5-(2-AMINOQUINAZOLIN-6-YL)-N-(4,4-DIMETHYL-2-OXO-1,2,3, 4-TETRAHYDROQUINOLIN-7-YL)-2-FLUOROBENZAMIDE4n3rAH1201 E1291
2GU5-(2-AMINOQUINAZOLIN-6-YL)-N-(4,4-DIMETHYL-2-OXO-1,2,3, 4-TETRAHYDROQUINOLIN-7-YL)-2-FLUOROBENZAMIDE4n3rBH1201 E1291
2C63-[(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)SULFANYL]-N- [TRANS-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL) CYCLOHEXYL]PROPANAMIDE4msgAH1201 E1291
2C63-[(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)SULFANYL]-N- [TRANS-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL) CYCLOHEXYL]PROPANAMIDE4msgBH1201 E1291
2C83-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[4-(5-PHENYL-1, 3,4-OXADIAZOL-2-YL)PHENYL]PROPANAMIDE4mskAH1201 E1291
2C83-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[4-(5-PHENYL-1, 3,4-OXADIAZOL-2-YL)PHENYL]PROPANAMIDE4mskBH1201 E1291
2C83-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[4-(5-PHENYL-1, 3,4-OXADIAZOL-2-YL)PHENYL]PROPANAMIDE4mskCH1201 E1291
2C83-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[4-(5-PHENYL-1, 3,4-OXADIAZOL-2-YL)PHENYL]PROPANAMIDE4mskDH1201 E1291
2D6N-[TRANS-4-(4-CYANOPHENOXY)CYCLOHEXYL]-3-[(4-OXO-3,4- DIHYDROQUINAZOLIN-2-YL)SULFANYL]PROPANAMIDE4mt9AH1201 E1291
2D6N-[TRANS-4-(4-CYANOPHENOXY)CYCLOHEXYL]-3-[(4-OXO-3,4- DIHYDROQUINAZOLIN-2-YL)SULFANYL]PROPANAMIDE4mt9BH1201 E1291
T405-METHYL-3-[4-(PIPERAZIN-1-YLMETHYL)PHENYL] ISOQUINOLIN-1(2H)-ONE4uuhAH1201 E1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1BH1201 E1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1EH1201 E1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1FH1201 E1291
92R3-{4-[(DIMETHYLAMINO)METHYL]PHENYL}-5- METHOXYISOQUINOLIN-1(2H)-ONE4uw1HH1201 E1291
5N22-[4-[3-[(4-OXIDANYLIDENE-3~{H}-PHTHALAZIN-1-YL) METHYL]PHENYL]CARBONYLPIPERAZIN-1-YL]PYRIDINE-3- CARBONITRILE5eceAH1201 E1291
5N22-[4-[3-[(4-OXIDANYLIDENE-3~{H}-PHTHALAZIN-1-YL) METHYL]PHENYL]CARBONYLPIPERAZIN-1-YL]PYRIDINE-3- CARBONITRILE5eceBH1201 E1291
5N22-[4-[3-[(4-OXIDANYLIDENE-3~{H}-PHTHALAZIN-1-YL) METHYL]PHENYL]CARBONYLPIPERAZIN-1-YL]PYRIDINE-3- CARBONITRILE5eceCH1201 E1291
K4F4-[(4S)-5,5-DIMETHYL-2-OXO-4-PHENYL-1,3-OXAZOLIDIN-3- YL]-N-(QUINOLIN-8-YL)BENZAMIDE4k4fBH1201 G1206
2XS4-[(3AR,4R,7S,7AS)-1,3-DIOXO-1,3,3A,4,7,7A-HEXAHYDRO- 2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL) BENZAMIDE4oa7BH1201 M1207
2XS4-[(3AR,4R,7S,7AS)-1,3-DIOXO-1,3,3A,4,7,7A-HEXAHYDRO- 2H-4,7-METHANOISOINDOL-2-YL]-N-(QUINOLIN-8-YL) BENZAMIDE4oa7DH1201 M1207
355TRANS-N-BENZYL-4-({1-[(6-METHYL-4-OXO-4H-PYRIDO[1,2- A]PYRIMIDIN-2-YL)METHYL]-2,4-DIOXO-1,4- DIHYDROQUINAZOLIN-3(2H)-YL}METHYL) CYCLOHEXANECARBOXAMIDE4tosAH1201 M1207


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Conservation information for LBS of TNKS
Multiple alignments for O95271 in multiple species
LBSAA sequence# speciesSpecies


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