mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TRIM24
Gene summary
Basic gene Info.Gene symbolTRIM24
Gene nametripartite motif containing 24
SynonymsPTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1
CytomapUCSC genome browser: 7q32-q34
Type of geneprotein-coding
RefGenesNM_003852.3,
NM_015905.2,
DescriptionE3 ubiquitin-protein ligase TRIM24RING finger protein 82TIF1-alphatranscription intermediary factor 1-alphatranscriptional intermediary factor 1tripartite motif-containing 24
Modification date20141222
dbXrefs MIM : 603406
HGNC : HGNC
Ensembl : ENSG00000122779
HPRD : 04556
Vega : OTTHUMG00000155820
ProteinUniProt: O15164
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TRIM24
BioGPS: 8805
PathwayNCI Pathway Interaction Database: TRIM24
KEGG: TRIM24
REACTOME: TRIM24
Pathway Commons: TRIM24
ContextiHOP: TRIM24
ligand binding site mutation search in PubMed: TRIM24
UCL Cancer Institute: TRIM24
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0016567protein ubiquitination19556538
GO:0071391cellular response to estrogen stimulus21164480


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Ligand binding site mutations for TRIM24

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C844C844YCOAD1
M958,Y956S957PCOAD1
C867I866LKIRC1
T947L945FKIRC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TRIM24
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T947L945F-1.5037239
C844C844Y-1.1661397
M958S957P-0.95980079
Y956S957P-0.95980079
C867I866L-0.68249447
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TRIM24 from PDB

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Differential gene expression and gene-gene network for TRIM24
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TRIM24 and the right PPI network was created from samples without mutations in the LBS of TRIM24. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TRIM24
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2239176Carcinoma, Hepatocellular2Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TRIM24
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TRIM24 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)3o33AC844 C867
ZNZINC(2+)3o33BC844 C867
ZNZINC(2+)3o33CC844 C867
ZNZINC(2+)3o33DC844 C867
ZNZINC(2+)3o34AC844 C867
ZNZINC(2+)3o35AC844 C867
ZNZINC(2+)3o35BC844 C867
ZNZINC(2+)3o36AC844 C867
ZNZINC(2+)3o36BC844 C867
ZNZINC(2+)3o37AC844 C867
ZNZINC(2+)3o37BC844 C867
ZNZINC(2+)3o37CC844 C867
ZNZINC(2+)3o37DC844 C867
ZNZINC(2+)4zqlAC844 C867
ZNZINC(2+)4zqlBC844 C867
ZNZINC(2+)4yabAC844 C867
ZNZINC(2+)4yabBC844 C867
ZNZINC(2+)4yadAC844 C867
ZNZINC(2+)4yadBC844 C867
ZNZINC(2+)4yatAC844 C867
ZNZINC(2+)4yatBC844 C867
ZNZINC(2+)4yaxAC844 C867
ZNZINC(2+)4yaxBC844 C867
ZNZINC(2+)4ybmAC844 C867
ZNZINC(2+)4ybmBC844 C867
ZNZINC(2+)4ybsAC844 C867
ZNZINC(2+)4ybtAC844 C867
ZNZINC(2+)4yc9AC844 C867
4BJN-{6-[3-(BENZYLOXY)PHENOXY]-1,3-DIMETHYL-2-OXO-2,3- DIHYDRO-1H-BENZIMIDAZOL-5-YL}-3,4- DIMETHOXYBENZENESULFONAMIDE4ybmBT947 Y956 M958


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Conservation information for LBS of TRIM24
Multiple alignments for O15164 in multiple species
LBSAA sequence# speciesSpecies


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