mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PAPSS2
Gene summary
Basic gene Info.Gene symbolPAPSS2
Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 2
CytomapUCSC genome browser: 10q24
Type of geneprotein-coding
Description3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2ATP sulfurylase/APS kinase 2ATP sulfurylase/adenosine 5'-phosphosulfate kinasePAPS synthase 2PAPS synthetase 2SK 2bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2bifunctional 3'
Modification date20141207
dbXrefs MIM : 603005
Ensembl : ENSG00000198682
HPRD : 04303
Vega : OTTHUMG00000018683
ProteinUniProt: O95340
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PAPSS2
BioGPS: 9060
PathwayNCI Pathway Interaction Database: PAPSS2
Pathway Commons: PAPSS2
ContextiHOP: PAPSS2
ligand binding site mutation search in PubMed: PAPSS2
UCL Cancer Institute: PAPSS2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PAPSS2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PAPSS2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PAPSS2 from PDB

Differential gene expression and gene-gene network for PAPSS2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PAPSS2 and the right PPI network was created from samples without mutations in the LBS of PAPSS2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PAPSS2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2748515Spondyloepimetaphyseal Dysplasia, Pakistani Type1Biomarker, GeneticVariation
umls:C2748516Spondylodysplasia And Premature Pubarche1Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PAPSS2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PAPSS2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PAPSS2
Multiple alignments for O95340 in multiple species
LBSAA sequence# speciesSpecies
A53-----------3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
A53TGLSGAGKTTI2Homo sapiens, Mus musculus
A53----------M1Arabidopsis thaliana
C202-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C202STVSDCVHQVV1Homo sapiens
C202SSVSDCVQQVV1Mus musculus
G52-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G52LTGLSGAGKTT2Homo sapiens, Mus musculus
G54-----------3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G54GLSGAGKTTIS2Homo sapiens, Mus musculus
G54---------MS1Arabidopsis thaliana
I58-----------3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I58AGKTTISFALE2Homo sapiens, Mus musculus
I58-----MSLMIR1Arabidopsis thaliana
K55-----------3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K55LSGAGKTTISF2Homo sapiens, Mus musculus
K55--------MSL1Arabidopsis thaliana
R158NICESRDVKGL2Homo sapiens, Mus musculus
R158TMQSVSKMT--1Arabidopsis thaliana
R158RQVSRRGLS--1Arabidopsis thaliana
R158LRR--RVGS--1Arabidopsis thaliana
R158KTRSLRTIS--1Arabidopsis thaliana
S197-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
S197LKTNLSTVSDC1Homo sapiens
S197LKTNLSSVSDC1Mus musculus
T194KLV--------2Arabidopsis thaliana, Arabidopsis thaliana
T194ERVLKTNLSTV1Homo sapiens
T194ECVLKTNLSSV1Mus musculus
T194ELV--------1Arabidopsis thaliana
T194KLM--------1Arabidopsis thaliana
T198-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T198KTNLSTVSDCV1Homo sapiens
T198KTNLSSVSDCV1Mus musculus
T56-----------3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T56SGAGKTTISFA2Homo sapiens, Mus musculus
T56-------MSLM1Arabidopsis thaliana
T57-----------3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T57GAGKTTISFAL2Homo sapiens, Mus musculus
T57------MSLMI1Arabidopsis thaliana
V160CESRDVKGLYK2Homo sapiens, Mus musculus
V160QSVSKMT----1Arabidopsis thaliana
V160VSRRGLS----1Arabidopsis thaliana
V160R--RVGS----1Arabidopsis thaliana
V160RSLRTIS----1Arabidopsis thaliana
V199-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
V199TNLSTVSDCVH1Homo sapiens
V199TNLSSVSDCVQ1Mus musculus

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