mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PAPSS1
Gene summary
Basic gene Info.Gene symbolPAPSS1
Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 1
SynonymsATPSK1|PAPSS|SK1
CytomapUCSC genome browser: 4q24
Type of geneprotein-coding
RefGenesNM_005443.4,
Description3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1sulfurylase kinase 1
Modification date20141207
dbXrefs MIM : 603262
HGNC : HGNC
Ensembl : ENSG00000138801
HPRD : 09132
Vega : OTTHUMG00000131210
ProteinUniProt: O43252
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PAPSS1
BioGPS: 9061
PathwayNCI Pathway Interaction Database: PAPSS1
KEGG: PAPSS1
REACTOME: PAPSS1
Pathway Commons: PAPSS1
ContextiHOP: PAPSS1
ligand binding site mutation search in PubMed: PAPSS1
UCL Cancer Institute: PAPSS1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PAPSS1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R92R92HCOAD1
L431M432TLUAD1
R139R139HOV1
R561P559LSKCM1
T186T186ISKCM1
R139R139SSKCM1
F185F185SSTAD1
A63A63ESTAD1
R522R522GUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PAPSS1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F185F185S-1.4276923
R92R92H-1.2169682
R139R139S-1.2092043
R139R139H-1.1895444
R522R522G-1.1164882
L431M432T-0.9202994
A63A63E-0.79785199
R561P559L-0.4264349
T186T186I-0.1556933
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PAPSS1 from PDB

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Differential gene expression and gene-gene network for PAPSS1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PAPSS1 and the right PPI network was created from samples without mutations in the LBS of PAPSS1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PAPSS1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PAPSS1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02661Adenosine-5'-Diphosphate-2',3'-VanadateSmall molecule
ExperimentalDB03708Adenosine-5'-PhosphosulfateSmall molecule
ExperimentalDB04077GlycerolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PAPSS1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ADPADP1x6vBA63
ADPADP1xjqBA63
ADPADP1xnjBA63
ADX5'-ADENYLYL SULFATE2ofwAA63
ADX5'-ADENYLYL SULFATE2ofwBA63
ADX5'-ADENYLYL SULFATE2ofwCA63
ADX5'-ADENYLYL SULFATE2ofwDA63
ADX5'-ADENYLYL SULFATE2ofwEA63
ADX5'-ADENYLYL SULFATE2ofwFA63
ADX5'-ADENYLYL SULFATE2ofwGA63
ADX5'-ADENYLYL SULFATE2ofwHA63
ADPADP2ofxAA63
ADPADP2ofxBA63
DATDADP2peyAA63
DATDADP2peyBA63
DATDADP2pezAA63
DATDADP2pezBA63
ADPADP1xjqBL431 R522 R561
ADPADP1xjqAL431 R522 R561
ADX5'-ADENYLYL SULFATE1xnjBL431 R522 R561
ADX5'-ADENYLYL SULFATE2qjfAL431 R522 R561
ADX5'-ADENYLYL SULFATE2qjfBL431 R522 R561
PO4PHOSPHATE ION2ofxAR139
PO4PHOSPHATE ION2ofxBR139
ADX5'-ADENYLYL SULFATE1xnjAR522 R561
ADX5'-ADENYLYL SULFATE1xnjBR92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwAR92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwBR92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwCR92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwDR92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwER92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwFR92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwGR92 F185 T186
ADX5'-ADENYLYL SULFATE2ofwHR92 F185 T186
PPS3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE2ofxAR92 F185 T186
PPS3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE2ofxBR92 F185 T186
ADX5'-ADENYLYL SULFATE2peyAR92 F185 T186
GGZ(2S,3AR,4R,6R,6AR)-4-(6-AMINO-9H-PURIN-9-YL)-6-({[(R)-HYDROXY(SULFOOXY)PHOSPHORYL]OXY}METHYL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-2-OL 2-OXIDE2pezAR92 F185 T186


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Conservation information for LBS of PAPSS1
Multiple alignments for O43252 in multiple species
LBSAA sequence# speciesSpecies
A197YEKPEAPELVL2Homo sapiens, Mus musculus
A197YEAPKAPELHL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A197YEAPISPEIVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A525VGRDPAGMPHP2Homo sapiens, Mus musculus
A525-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A563VPFRVAAYNKK2Homo sapiens, Mus musculus
A563-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A63TGLSGAGKTTV2Homo sapiens, Mus musculus
A63TGLSASGKSTI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C207LKTDSCDVNDC2Homo sapiens, Mus musculus
C207LRTDQKTVEEC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C207VSSHTQSIEEC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C212CDVNDCVQQVV2Homo sapiens, Mus musculus
C212KTVEECATIIY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C212QSIEECVEKIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D208KTDSCDVNDCV2Homo sapiens, Mus musculus
D208RTDQKTVEECA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D208SSHTQSIEECV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D89YTLDGDNIRQG2Homo sapiens, Mus musculus
D89YRLDGDNIRFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D89YRLDGDNVRFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E155SLPFFEVFVDA2Homo sapiens, Mus musculus
E155GLKFIEIFVDV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E155GLPFIEVYVEC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E196EYEKPEAPELV2Homo sapiens, Mus musculus
E196PYEAPKAPELH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E196PYEAPISPEIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F101NKNLGFSPEDR2Homo sapiens, Mus musculus
F101NKDLGFSEKDR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F101NSDLGFSEQDR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F131VCITSFISPYT2Homo sapiens, Mus musculus
F131ISITSFISPYR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F131VAVTSFISPYR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F185GEIKGFTGIDS2Homo sapiens, Mus musculus
F185GVIKEFTGISA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F185GEIKEFTGISA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F418DAVFAFQLRNP2Homo sapiens, Mus musculus
F418-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G184AGEIKGFTGID2Homo sapiens, Mus musculus
G184EGVIKEFTGIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G184AGEIKEFTGIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G521NFYIVGRDPAG2Homo sapiens, Mus musculus
G521-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G62LTGLSGAGKTT2Homo sapiens, Mus musculus
G62LTGLSASGKST1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G62MTGLSASGKST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G64GLSGAGKTTVS2Homo sapiens, Mus musculus
G64GLSASGKSTIA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G88CYTLDGDNIRQ2Homo sapiens, Mus musculus
G88AYRLDGDNIRF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G88TYRLDGDNVRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H428PVHNGHALLMQ2Homo sapiens, Mus musculus
H428-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I132CITSFISPYTQ2Homo sapiens, Mus musculus
I132SITSFISPYRV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I132AVTSFISPYRK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K171EQRDVKGLYKK2Homo sapiens, Mus musculus
K171EQRDPKGLYKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K171EQRDPKGLYKR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K183RAGEIKGFTGI2Homo sapiens, Mus musculus
K183REGVIKEFTGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K183RAGEIKEFTGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K65LSGAGKTTVSM2Homo sapiens, Mus musculus
K65LSASGKSTIAC2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L173RDVKGLYKKAR2Homo sapiens, Mus musculus
L173RDPKGLYKKAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L173RDPKGLYKRAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L420VFAFQLRNPVH2Homo sapiens, Mus musculus
L420-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L431NGHALLMQDTH2Homo sapiens, Mus musculus
L431-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L60VWLTGLSGAGK2Homo sapiens, Mus musculus
L60IWLTGLSASGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L60IWMTGLSASGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M495IFPSPMMYAGP2Homo sapiens, Mus musculus
M495-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N109EDREENVRRIA2Homo sapiens, Mus musculus
N109KDRNENIRRIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N109QDRNENIRRIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N140YTQDRNNARQI2Homo sapiens, Mus musculus
N140YRVDRDRAREL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N140YRKDRDQAREF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N27MQRATNVTYQA2Homo sapiens, Mus musculus
N27--MATNITWHP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N27--MATNITFHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N422AFQLRNPVHNG2Homo sapiens, Mus musculus
N422-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P134TSFISPYTQDR2Homo sapiens, Mus musculus
P134TSFISPYRVDR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P134TSFISPYRKDR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P195SEYEKPEAPEL2Homo sapiens, Mus musculus
P195APYEAPKAPEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P195APYEAPISPEI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P198EKPEAPELVLK2Homo sapiens, Mus musculus
P198EAPKAPELHLR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P198EAPISPEIVVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P524IVGRDPAGMPH2Homo sapiens, Mus musculus
P524-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q419AVFAFQLRNPV2Homo sapiens, Mus musculus
Q419-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R106FSPEDREENVR2Homo sapiens, Mus musculus
R106FSEKDRNENIR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R106FSEQDRNENIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R139PYTQDRNNARQ2Homo sapiens, Mus musculus
R139PYRVDRDRARE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R139PYRKDRDQARE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R168HVCEQRDVKGL2Homo sapiens, Mus musculus
R168EVAEQRDPKGL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R421FAFQLRNPVHN2Homo sapiens, Mus musculus
R421-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R522FYIVGRDPAGM2Homo sapiens, Mus musculus
R522-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R561EIVPFRVAAYN2Homo sapiens, Mus musculus
R561-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R92DGDNIRQGLNK2Homo sapiens, Mus musculus
R92DGDNIRFGLNK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R92DGDNVRFGLNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S133ITSFISPYTQD2Homo sapiens, Mus musculus
S133ITSFISPYRVD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S133VTSFISPYRKD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S61WLTGLSGAGKT2Homo sapiens, Mus musculus
S61WLTGLSASGKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S61WMTGLSASGKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T186EIKGFTGIDSE2Homo sapiens, Mus musculus
T186VIKEFTGISAP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T186EIKEFTGISAP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T204ELVLKTDSCDV2Homo sapiens, Mus musculus
T204ELHLRTDQKTV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T204EIVVSSHTQSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T26GMQRATNVTYQ2Homo sapiens, Mus musculus
T26---MATNITWH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T26---MATNITFH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T66SGAGKTTVSMA2Homo sapiens, Mus musculus
T66SASGKSTIACA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T67GAGKTTVSMAL2Homo sapiens, Mus musculus
T67ASGKSTIACAL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V170CEQRDVKGLYK2Homo sapiens, Mus musculus
V170AEQRDPKGLYK2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V209TDSCDVNDCVQ2Homo sapiens, Mus musculus
V209TDQKTVEECAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V209SHTQSIEECVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V28QRATNVTYQAH2Homo sapiens, Mus musculus
V28-MATNITWHP-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V28-MATNITFHPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V520ANFYIVGRDPA2Homo sapiens, Mus musculus
V520-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V562IVPFRVAAYNK2Homo sapiens, Mus musculus
V562-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V68AGKTTVSMALE2Homo sapiens, Mus musculus
V68SGKSTIACALE2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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