mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MMP20
Gene summary
Basic gene Info.Gene symbolMMP20
Gene namematrix metallopeptidase 20
CytomapUCSC genome browser: 11q22.3
Type of geneprotein-coding
Descriptionenamel metalloproteinasematrix metalloproteinase 20 (enamelysin)matrix metalloproteinase-20
Modification date20141207
dbXrefs MIM : 604629
Ensembl : ENSG00000137674
HPRD : 05218
Vega : OTTHUMG00000168081
ProteinUniProt: O60882
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MMP20
BioGPS: 9313
PathwayNCI Pathway Interaction Database: MMP20
Pathway Commons: MMP20
ContextiHOP: MMP20
ligand binding site mutation search in PubMed: MMP20
UCL Cancer Institute: MMP20
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for MMP20
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MMP20
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MMP20 from PDB

Differential gene expression and gene-gene network for MMP20
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MMP20 and the right PPI network was created from samples without mutations in the LBS of MMP20. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MMP20
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MMP20
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00786MarimastatSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MMP20 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of MMP20
Multiple alignments for O60882 in multiple species
LBSAA sequence# speciesSpecies
A165INSGEADIMIS2Homo sapiens, Mus musculus
A165INAGEADIMIS1Bos taurus
A190PRGTLAHAFAP3Homo sapiens, Bos taurus, Mus musculus
D166NSGEADIMISF2Homo sapiens, Mus musculus
D166NAGEADIMISF1Bos taurus
D178TGDHGDSYPFD2Bos taurus, Mus musculus
D178NGDHGDSYPFD1Homo sapiens
D183DSYPFDGPRGT3Homo sapiens, Bos taurus, Mus musculus
D202EGLGGDTHFDN3Homo sapiens, Bos taurus, Mus musculus
D206GDTHFDNAEKW3Homo sapiens, Bos taurus, Mus musculus
E164RINSGEADIMI2Homo sapiens, Mus musculus
E164RINAGEADIMI1Bos taurus
E197AFAPGEGLGGD3Homo sapiens, Bos taurus, Mus musculus
E209HFDNAEKWTMG3Homo sapiens, Bos taurus, Mus musculus
E227TVAAHEFGHAL3Homo sapiens, Bos taurus, Mus musculus
G184SYPFDGPRGTL3Homo sapiens, Bos taurus, Mus musculus
G187FDGPRGTLAHA3Homo sapiens, Bos taurus, Mus musculus
G198FAPGEGLGGDT3Homo sapiens, Bos taurus, Mus musculus
G200PGEGLGGDTHF3Homo sapiens, Bos taurus, Mus musculus
H176FETGDHGDSYP2Bos taurus, Mus musculus
H176FENGDHGDSYP1Homo sapiens
H191RGTLAHAFAPG3Homo sapiens, Bos taurus, Mus musculus
H204LGGDTHFDNAE3Homo sapiens, Bos taurus, Mus musculus
H226FTVAAHEFGHA3Homo sapiens, Bos taurus, Mus musculus
H230AHEFGHALGLA2Homo sapiens, Bos taurus
H230AHEFGHALGLG1Mus musculus
H236ALGLAHSTDPS2Homo sapiens, Bos taurus
H236ALGLGHSTDPS1Mus musculus
K249MYPTYKYKNPY1Homo sapiens
K249MFPTYKYQNPY1Bos taurus
K249MYPTYKYQNPY1Mus musculus
L189GPRGTLAHAFA3Homo sapiens, Bos taurus, Mus musculus
P246SALMYPTYKYK1Homo sapiens
P246SALMFPTYKYQ1Bos taurus
P246SALMYPTYKYQ1Mus musculus
R186PFDGPRGTLAH3Homo sapiens, Bos taurus, Mus musculus
T188DGPRGTLAHAF3Homo sapiens, Bos taurus, Mus musculus
T222GFNLFTVAAHE3Homo sapiens, Bos taurus, Mus musculus
T247ALMYPTYKYKN1Homo sapiens
T247ALMFPTYKYQN1Bos taurus
T247ALMYPTYKYQN1Mus musculus
V223FNLFTVAAHEF3Homo sapiens, Bos taurus, Mus musculus
Y245PSALMYPTYKY2Homo sapiens, Mus musculus
Y245PSALMFPTYKY1Bos taurus
Y248LMYPTYKYKNP1Homo sapiens
Y248LMFPTYKYQNP1Bos taurus
Y248LMYPTYKYQNP1Mus musculus

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