mutLBSgeneDB |
Gene summary for MMP20 |
Gene summary |
Basic gene Info. | Gene symbol | MMP20 |
Gene name | matrix metallopeptidase 20 | |
Synonyms | AI2A2|MMP-20 | |
Cytomap | UCSC genome browser: 11q22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_004771.3, | |
Description | enamel metalloproteinasematrix metalloproteinase 20 (enamelysin)matrix metalloproteinase-20 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604629 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137674 | ||
HPRD : 05218 | ||
Vega : OTTHUMG00000168081 | ||
Protein | UniProt: O60882 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MMP20 | |
BioGPS: 9313 | ||
Pathway | NCI Pathway Interaction Database: MMP20 | |
KEGG: MMP20 | ||
REACTOME: MMP20 | ||
Pathway Commons: MMP20 | ||
Context | iHOP: MMP20 | |
ligand binding site mutation search in PubMed: MMP20 | ||
UCL Cancer Institute: MMP20 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for MMP20 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | E164 | E164D | KIRC | 1 | T222 | F221L | SKCM | 1 | D183 | P181Q | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for MMP20 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E164 | E164D | -1.2255482 | D183 | P181Q | -1.1408036 | T222 | F221L | -0.69264894 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MMP20 from PDB |
Top |
Differential gene expression and gene-gene network for MMP20 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for MMP20 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for MMP20 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB00786 | Marimastat | Small molecule | |
Experimental | DB08271 | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MMP20 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 2jsd | A | D183 | CA | CALCIUM(2+) | 2jsd | A | E164 | NGH | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYLHYDROXAMIC ACID | 2jsd | A | T222 |
Top |
Conservation information for LBS of MMP20 |
Multiple alignments for O60882 in multiple species |
LBS | AA sequence | # species | Species | A165 | INSGEADIMIS | 2 | Homo sapiens, Mus musculus | A165 | INAGEADIMIS | 1 | Bos taurus | A190 | PRGTLAHAFAP | 3 | Homo sapiens, Bos taurus, Mus musculus | D166 | NSGEADIMISF | 2 | Homo sapiens, Mus musculus | D166 | NAGEADIMISF | 1 | Bos taurus | D178 | TGDHGDSYPFD | 2 | Bos taurus, Mus musculus | D178 | NGDHGDSYPFD | 1 | Homo sapiens | D183 | DSYPFDGPRGT | 3 | Homo sapiens, Bos taurus, Mus musculus | D202 | EGLGGDTHFDN | 3 | Homo sapiens, Bos taurus, Mus musculus | D206 | GDTHFDNAEKW | 3 | Homo sapiens, Bos taurus, Mus musculus | E164 | RINSGEADIMI | 2 | Homo sapiens, Mus musculus | E164 | RINAGEADIMI | 1 | Bos taurus | E197 | AFAPGEGLGGD | 3 | Homo sapiens, Bos taurus, Mus musculus | E209 | HFDNAEKWTMG | 3 | Homo sapiens, Bos taurus, Mus musculus | E227 | TVAAHEFGHAL | 3 | Homo sapiens, Bos taurus, Mus musculus | G184 | SYPFDGPRGTL | 3 | Homo sapiens, Bos taurus, Mus musculus | G187 | FDGPRGTLAHA | 3 | Homo sapiens, Bos taurus, Mus musculus | G198 | FAPGEGLGGDT | 3 | Homo sapiens, Bos taurus, Mus musculus | G200 | PGEGLGGDTHF | 3 | Homo sapiens, Bos taurus, Mus musculus | H176 | FETGDHGDSYP | 2 | Bos taurus, Mus musculus | H176 | FENGDHGDSYP | 1 | Homo sapiens | H191 | RGTLAHAFAPG | 3 | Homo sapiens, Bos taurus, Mus musculus | H204 | LGGDTHFDNAE | 3 | Homo sapiens, Bos taurus, Mus musculus | H226 | FTVAAHEFGHA | 3 | Homo sapiens, Bos taurus, Mus musculus | H230 | AHEFGHALGLA | 2 | Homo sapiens, Bos taurus | H230 | AHEFGHALGLG | 1 | Mus musculus | H236 | ALGLAHSTDPS | 2 | Homo sapiens, Bos taurus | H236 | ALGLGHSTDPS | 1 | Mus musculus | K249 | MYPTYKYKNPY | 1 | Homo sapiens | K249 | MFPTYKYQNPY | 1 | Bos taurus | K249 | MYPTYKYQNPY | 1 | Mus musculus | L189 | GPRGTLAHAFA | 3 | Homo sapiens, Bos taurus, Mus musculus | P246 | SALMYPTYKYK | 1 | Homo sapiens | P246 | SALMFPTYKYQ | 1 | Bos taurus | P246 | SALMYPTYKYQ | 1 | Mus musculus | R186 | PFDGPRGTLAH | 3 | Homo sapiens, Bos taurus, Mus musculus | T188 | DGPRGTLAHAF | 3 | Homo sapiens, Bos taurus, Mus musculus | T222 | GFNLFTVAAHE | 3 | Homo sapiens, Bos taurus, Mus musculus | T247 | ALMYPTYKYKN | 1 | Homo sapiens | T247 | ALMFPTYKYQN | 1 | Bos taurus | T247 | ALMYPTYKYQN | 1 | Mus musculus | V223 | FNLFTVAAHEF | 3 | Homo sapiens, Bos taurus, Mus musculus | Y245 | PSALMYPTYKY | 2 | Homo sapiens, Mus musculus | Y245 | PSALMFPTYKY | 1 | Bos taurus | Y248 | LMYPTYKYKNP | 1 | Homo sapiens | Y248 | LMFPTYKYQNP | 1 | Bos taurus | Y248 | LMYPTYKYQNP | 1 | Mus musculus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |