mutLBSgeneDB |
Gene summary for ZRANB2 |
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Basic gene Info. | Gene symbol | ZRANB2 |
Gene name | zinc finger, RAN-binding domain containing 2 | |
Synonyms | ZIS|ZIS1|ZIS2|ZNF265 | |
Cytomap | UCSC genome browser: 1p31 | |
Type of gene | protein-coding | |
RefGenes | NM_005455.4, NM_203350.2, | |
Description | zinc finger Ran-binding domain-containing protein 2zinc finger protein 265zinc finger, splicingzinc-finger protein 265zinc-finger, splicing | |
Modification date | 20141207 | |
dbXrefs | MIM : 604347 | |
HGNC : HGNC | ||
Ensembl : ENSG00000132485 | ||
HPRD : 09185 | ||
Vega : OTTHUMG00000009660 | ||
Protein | UniProt: O95218 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZRANB2 | |
BioGPS: 9406 | ||
Pathway | NCI Pathway Interaction Database: ZRANB2 | |
KEGG: ZRANB2 | ||
REACTOME: ZRANB2 | ||
Pathway Commons: ZRANB2 | ||
Context | iHOP: ZRANB2 | |
ligand binding site mutation search in PubMed: ZRANB2 | ||
UCL Cancer Institute: ZRANB2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ZRANB2 |
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LBS | AAchange of nsSNV | Cancer type | # samples | C34 | G35S | COAD | 2 | C71 | C71F | BRCA | 1 | C85 | E84D | HNSC | 1 | C34 | G35C | OV | 1 | C34 | R33Q | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZRANB2 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C34 | R33Q | -1.023688 | C71 | C71F | -1.0111152 | C85 | E84D | -0.87243267 | C34 | G35S | -0.74998779 | C34 | G35C | -0.53277259 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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PDB ID | PDB title | PDB structure | 2K1P | Solution structure of the second zinc finger domain of ZRANB2/ZNF265 | ![]() |
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Differential gene expression and gene-gene network for ZRANB2 |
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Phenotype information for ZRANB2 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZRANB2 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2k1p | A | C71 C85 |
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Conservation information for LBS of ZRANB2 |
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LBS | AA sequence | # species | Species |
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