mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZRANB2
Gene summary
Basic gene Info.Gene symbolZRANB2
Gene namezinc finger, RAN-binding domain containing 2
SynonymsZIS|ZIS1|ZIS2|ZNF265
CytomapUCSC genome browser: 1p31
Type of geneprotein-coding
RefGenesNM_005455.4,
NM_203350.2,
Descriptionzinc finger Ran-binding domain-containing protein 2zinc finger protein 265zinc finger, splicingzinc-finger protein 265zinc-finger, splicing
Modification date20141207
dbXrefs MIM : 604347
HGNC : HGNC
Ensembl : ENSG00000132485
HPRD : 09185
Vega : OTTHUMG00000009660
ProteinUniProt: O95218
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZRANB2
BioGPS: 9406
PathwayNCI Pathway Interaction Database: ZRANB2
KEGG: ZRANB2
REACTOME: ZRANB2
Pathway Commons: ZRANB2
ContextiHOP: ZRANB2
ligand binding site mutation search in PubMed: ZRANB2
UCL Cancer Institute: ZRANB2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ZRANB2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C34G35SCOAD2
C71C71FBRCA1
C85E84DHNSC1
C34G35COV1
C34R33QUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ZRANB2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C34R33Q-1.023688
C71C71F-1.0111152
C85E84D-0.87243267
C34G35S-0.74998779
C34G35C-0.53277259
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZRANB2 from PDB
PDB IDPDB titlePDB structure
2K1PSolution structure of the second zinc finger domain of ZRANB2/ZNF265

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Differential gene expression and gene-gene network for ZRANB2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZRANB2 and the right PPI network was created from samples without mutations in the LBS of ZRANB2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ZRANB2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ZRANB2
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZRANB2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)2k1pAC71 C85


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Conservation information for LBS of ZRANB2
Multiple alignments for O95218 in multiple species
LBSAA sequence# speciesSpecies


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