mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CD38
Gene summary
Basic gene Info.Gene symbolCD38
Gene nameCD38 molecule
SynonymsADPRC 1|T10
CytomapUCSC genome browser: 4p15
Type of geneprotein-coding
RefGenesNM_001775.2,
Description2'-phospho-ADP-ribosyl cyclase2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase2'-phospho-cyclic-ADP-ribose transferaseADP-ribosyl cyclase 1ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1CD38 antigen (p45)NAD(+) nucleosidase
Modification date20141222
dbXrefs MIM : 107270
HGNC : HGNC
HPRD : 00116
ProteinUniProt: P28907
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CD38
BioGPS: 952
PathwayNCI Pathway Interaction Database: CD38
KEGG: CD38
REACTOME: CD38
Pathway Commons: CD38
ContextiHOP: CD38
ligand binding site mutation search in PubMed: CD38
UCL Cancer Institute: CD38
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CD38
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R212R212CCOAD1
D147T148PLUAD1
D175D175GLUAD1
S220S220NLUSC1
V185N183IOV1
S126S126NSTAD1
K129K129QUCEC1
F222F222SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CD38
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S126S126N-0.98367777
S220S220N-0.79730198
D147T148P-0.79691568
F222F222S-0.78271897
R212R212C-0.74278683
V185N183I-0.69669288
D175D175G-0.60386798
K129K129Q-0.36982
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CD38 from PDB

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Differential gene expression and gene-gene network for CD38
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CD38 and the right PPI network was created from samples without mutations in the LBS of CD38. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CD38
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0151744Myocardial Ischemia2Biomarker
umls:C0001925Albuminuria1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CD38
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB09331DaratumumabBiotech

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CD38 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)3f6yAD147
APRADP-RIBOSE2i67BK129 R212
CXRCYCLIC ADENOSINE DIPHOSPHATE-RIBOSE2o3qAK129 V185
CXRCYCLIC ADENOSINE DIPHOSPHATE-RIBOSE2o3qBK129 V185
CXRCYCLIC ADENOSINE DIPHOSPHATE-RIBOSE2o3rAK129 V185
CXRCYCLIC ADENOSINE DIPHOSPHATE-RIBOSE2o3rBK129 V185
CXRCYCLIC ADENOSINE DIPHOSPHATE-RIBOSE2o3sAK129 V185
41Z4-[(2,6-DIMETHYLBENZYL)AMINO]-2-METHYLQUINOLINE-8- CARBOXAMIDE4xjtAK129 V185
7336-FLUORO-2-METHYL-4-[(2,3,6-TRICHLOROBENZYL) AMINO]QUINOLINE-8-CARBOXAMIDE4xjsAK129 V185 S220
RGT(RIBOSE-5'-PHOSPHATE)-(GUANOSINE-5'-TRIPHOSPHATE)3dziAS126 K129 D175 V185 S220 F222
NMNNICOTINAMIDE MONONUCLEOTIDE2hctAS126 K129 S220 F222
NMNNICOTINAMIDE MONONUCLEOTIDE2hctBS126 K129 S220 F222
CGRCYCLIC GUANOSINE DIPHOSPHATE-RIBOSE2o3tAS126 K129 S220 F222
AVUARA-2'F-ADPR3i9mAS126 K129 S220 F222
AVUARA-2'F-ADPR3i9mBS126 K129 S220 F222
AVUARA-2'F-ADPR3ofsAS126 K129 S220 F222
AVUARA-2'F-ADPR3ofsBS126 K129 S220 F222
AVUARA-2'F-ADPR3ofsCS126 K129 S220 F222
AVUARA-2'F-ADPR3ofsDS126 K129 S220 F222
AVUARA-2'F-ADPR3ofsFS126 K129 S220 F222
DVN[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4- PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(2R,3S,4R,5S)-3,4,5-TRIS(OXIDANYL)OXOLAN-2-YL]METHYL HYDROGEN PHOSPHATE4f46AS126 K129 V185 S220 F222
CACALCIUM(2+)3f6yAS126 S220
NADNAD ZWITTERION2i65AS126 S220 F222
NADNAD ZWITTERION2i65BS126 S220 F222
G1RGUANOSINE DIPHOSPHORIBOSE2i66AS126 S220 F222
G2RGUANOSINE DIPHOSPHORIBOSE INTERMEDIATE2i66BS126 S220 F222
APRADP-RIBOSE2i67AS126 S220 F222
APRADP-RIBOSE2i67BS126 S220 F222
NGDNICOTINAMIDE GUANINE DINUCLEOTIDE2o3uAS126 S220 F222
NGDNICOTINAMIDE GUANINE DINUCLEOTIDE2o3uBS126 S220 F222
N1CN1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE2pgjAS126 S220 F222
N1CN1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE2pglAS126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzfAS126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzfBS126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzfCS126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzfDS126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzfES126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzfFS126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzgAS126 S220 F222
RF51,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-ARABINITOL3dzgBS126 S220 F222
N3dziBS126 S220 F222
NMNNICOTINAMIDE MONONUCLEOTIDE3dzjAS126 S220 F222
NMNNICOTINAMIDE MONONUCLEOTIDE3dzjBS126 S220 F222
NMNNICOTINAMIDE MONONUCLEOTIDE3dzkAS126 S220 F222
NMNNICOTINAMIDE MONONUCLEOTIDE3dzkBS126 S220 F222
AVWRIBOSYL-2-FLUORO-DEOXY-ADENOSINE DIPHOSPHATE RIBOSE,RIBO-2'F-ADPR3i9nAS126 S220 F222
AVUARA-2'F-ADPR3ofsES126 S220 F222
27C1,4-ANHYDRO-5-O-[(R)-BUTOXY(HYDROXY)PHOSPHORYL]-2-DEOXY-2-FLUORO-D-ARABINITOL3rokAS126 S220 F222
27C1,4-ANHYDRO-5-O-[(R)-BUTOXY(HYDROXY)PHOSPHORYL]-2-DEOXY-2-FLUORO-D-ARABINITOL3rokBS126 S220 F222
48Z1,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-THIOPHOSPHONO-D-ARABINITOL3romAS126 S220 F222
48Z1,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-THIOPHOSPHONO-D-ARABINITOL3romBS126 S220 F222
50A1,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-RIBITOL3ropAS126 S220 F222
50A1,4-ANHYDRO-2-DEOXY-2-FLUORO-5-O-PHOSPHONO-D-RIBITOL3ropBS126 S220 F222
46Z(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL 2-PHENYLETHYL HYDROGEN (S)-PHOSPHATE3roqAS126 S220 F222
46Z(2R,3R,4R)-4-FLUORO-3-HYDROXYTETRAHYDROFURAN-2-YL 2-PHENYLETHYL HYDROGEN (S)-PHOSPHATE3roqBS126 S220 F222
C8R8-AMINO-N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE3u4hAS126 S220 F222
C8R8-AMINO-N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE3u4hBS126 S220 F222
CVRCYCLIC ADENOSINE 5'-DIPHOSPHOCARBOCYCLIC RIBOSE3u4iAS126 S220 F222
DN4NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4- PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4- BIS(OXIDANYL)OXOLAN-2-YL]METHYL PHOSPHATE4f45AS126 S220 F222
DN4NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4- PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4- BIS(OXIDANYL)OXOLAN-2-YL]METHYL PHOSPHATE4f45BS126 S220 F222
DN4NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4- PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4- BIS(OXIDANYL)OXOLAN-2-YL]METHYL PHOSPHATE4f46BS126 S220 F222
NMNNICOTINAMIDE MONONUCLEOTIDE4ogwAS126 S220 F222
JS28-NH2-HYPOXANTHINE-N9-BUTYL DIPHOSPHATE RIBOSE5-O-[(R)-{[(S)-[4-(8-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN- 9-YL)BUTOXY](HYDROXY)PHOSPHORYL]OXY}(HYDROXY) PHOSPHORYL]-ALPHA-D-RIBOFURANOSE4tmfAS126 S220 F222
HSXALPHA-D-RIBOSE 5-PHOSPHATE4xjsAS126 S220 F222
NA72'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE4xjtAS126 S220 F222
AVWRIBOSYL-2-FLUORO-DEOXY-ADENOSINE DIPHOSPHATE RIBOSE,RIBO-2'F-ADPR3i9nBS126 V185 S220 F222
JS28-NH2-HYPOXANTHINE-N9-BUTYL DIPHOSPHATE RIBOSE5-O-[(R)-{[(S)-[4-(8-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN- 9-YL)BUTOXY](HYDROXY)PHOSPHORYL]OXY}(HYDROXY) PHOSPHORYL]-ALPHA-D-RIBOFURANOSE4tmfBS126 V185 S220 F222
G1RGUANOSINE DIPHOSPHORIBOSE2i66AV185
CXRCYCLIC ADENOSINE DIPHOSPHATE-RIBOSE2o3sBV185
GTPGTP3dzhAV185
GTPGTP3dzhBV185
GTPGTP3dziBV185
G1RGUANOSINE DIPHOSPHORIBOSE2i66BV185 R212


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Conservation information for LBS of CD38
Multiple alignments for P28907 in multiple species
LBSAA sequence# speciesSpecies
D147MFTLEDTLLGY3Homo sapiens, Mus musculus, Rattus norvegicus
D155LGYIADDLRWC2Mus musculus, Rattus norvegicus
D155LGYLADDLTWC1Homo sapiens
D156GYIADDLRWCG2Mus musculus, Rattus norvegicus
D156GYLADDLTWCG1Homo sapiens
D175YQSCPDWRKDC1Homo sapiens
D175YVSCPHWSENC1Mus musculus
D175YDSCPHWSENC1Rattus norvegicus
E146KMFTLEDTLLG2Mus musculus, Rattus norvegicus
E146DMFTLEDTLLG1Homo sapiens
E226TFGSVEVHNLQ1Homo sapiens
E226TFGSVEVFSLD1Mus musculus
E226TFGSVEVFNLD1Rattus norvegicus
F222DKNSTFGSVEV1Homo sapiens
F222YKNSTFGSVEV1Mus musculus
F222YRNSTFGSVEV1Rattus norvegicus
K129FWSKSKHLAHQ2Mus musculus, Rattus norvegicus
K129LWSRIKDLAHQ1Homo sapiens
K190VSVFWKTVSRR1Homo sapiens
K190ITVFWKVISQK1Mus musculus
K190VAVFWNVISQK1Rattus norvegicus
L124CNKTLFWSKSK2Mus musculus, Rattus norvegicus
L124CNKILLWSRIK1Homo sapiens
L145GKMFTLEDTLL2Mus musculus, Rattus norvegicus
L145RDMFTLEDTLL1Homo sapiens
R127TLFWSKSKHLA2Mus musculus, Rattus norvegicus
R127ILLWSRIKDLA1Homo sapiens
R177SCPHWSENCPN2Mus musculus, Rattus norvegicus
R177SCPDWRKDCSN1Homo sapiens
R212MLNGSRSKIFD1Homo sapiens
R212MLNGSLREPFY1Mus musculus
R212MLNGSLSEPFY1Rattus norvegicus
S126KTLFWSKSKHL2Mus musculus, Rattus norvegicus
S126KILLWSRIKDL1Homo sapiens
S186SNNPVSVFWKT1Homo sapiens
S186PNNPITVFWKV1Mus musculus
S186PNNPVAVFWNV1Rattus norvegicus
S193FWKTVSRRFAE1Homo sapiens
S193FWKVISQKFAE1Mus musculus
S193FWNVISQKFAE1Rattus norvegicus
S220IFDKNSTFGSV1Homo sapiens
S220PFYKNSTFGSV1Mus musculus
S220PFYRNSTFGSV1Rattus norvegicus
S224NSTFGSVEVHN1Homo sapiens
S224NSTFGSVEVFS1Mus musculus
S224NSTFGSVEVFN1Rattus norvegicus
T144QGKMFTLEDTL2Mus musculus, Rattus norvegicus
T144QRDMFTLEDTL1Homo sapiens
T221FDKNSTFGSVE1Homo sapiens
T221FYKNSTFGSVE1Mus musculus
T221FYRNSTFGSVE1Rattus norvegicus
V185CSNNPVSVFWK1Homo sapiens
V185CPNNPITVFWK1Mus musculus
V185CPNNPVAVFWN1Rattus norvegicus
V225STFGSVEVHNL1Homo sapiens
V225STFGSVEVFSL1Mus musculus
V225STFGSVEVFNL1Rattus norvegicus
W125NKTLFWSKSKH2Mus musculus, Rattus norvegicus
W125NKILLWSRIKD1Homo sapiens
W176QSCPDWRKDCS1Homo sapiens
W176VSCPHWSENCP1Mus musculus
W176DSCPHWSENCP1Rattus norvegicus
W189PVSVFWKTVSR1Homo sapiens
W189PITVFWKVISQ1Mus musculus
W189PVAVFWNVISQ1Rattus norvegicus


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