mutLBSgeneDB |
Gene summary for KLK4 |
Gene summary |
Basic gene Info. | Gene symbol | KLK4 |
Gene name | kallikrein-related peptidase 4 | |
Synonyms | AI2A1|ARM1|EMSP|EMSP1|KLK-L1|PRSS17|PSTS|kallikrein | |
Cytomap | UCSC genome browser: 19q13.41 | |
Type of gene | protein-coding | |
RefGenes | NM_001302961.1, NM_004917.4,NR_126566.1, | |
Description | androgen-regulated message 1enamel matrix serine protease 1enamel matrix serine proteinase 1kallikrein-4kallikrein-like protein 1prostaseserine protease 17 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603767 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167749 | ||
HPRD : 04793 | ||
Vega : OTTHUMG00000182964 | ||
Protein | UniProt: Q9Y5K2 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLK4 | |
BioGPS: 9622 | ||
Pathway | NCI Pathway Interaction Database: KLK4 | |
KEGG: KLK4 | ||
REACTOME: KLK4 | ||
Pathway Commons: KLK4 | ||
Context | iHOP: KLK4 | |
ligand binding site mutation search in PubMed: KLK4 | ||
UCL Cancer Institute: KLK4 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for KLK4 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | H71 | A70T | BLCA | 1 | A226 | A226S | BRCA | 1 | L113 | P111H | KIRC | 1 | H40 | P39L | LUAD | 1 | L54 | E53K | SKCM | 1 | M161 | G159S | STAD | 1 | G235 | V233M | UCEC | 1 | H71 | A70T | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for KLK4 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H71 | A70T | -1.525274 | G235 | V233M | -1.4745709 | A226 | A226S | -0.79145141 | L54 | E53K | -0.77149898 | L113 | P111H | -0.59549823 | M161 | G159S | -0.56289737 | H40 | P39L | -0.002529335 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for KLK4 from PDB |
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Differential gene expression and gene-gene network for KLK4 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for KLK4 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for KLK4 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of KLK4 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of KLK4 |
Multiple alignments for Q9Y5K2 in multiple species |
LBS | AA sequence | # species | Species |
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