mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KLK4
Gene summary
Basic gene Info.Gene symbolKLK4
Gene namekallikrein-related peptidase 4
SynonymsAI2A1|ARM1|EMSP|EMSP1|KLK-L1|PRSS17|PSTS|kallikrein
CytomapUCSC genome browser: 19q13.41
Type of geneprotein-coding
RefGenesNM_001302961.1,
NM_004917.4,NR_126566.1,
Descriptionandrogen-regulated message 1enamel matrix serine protease 1enamel matrix serine proteinase 1kallikrein-4kallikrein-like protein 1prostaseserine protease 17
Modification date20141207
dbXrefs MIM : 603767
HGNC : HGNC
Ensembl : ENSG00000167749
HPRD : 04793
Vega : OTTHUMG00000182964
ProteinUniProt: Q9Y5K2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLK4
BioGPS: 9622
PathwayNCI Pathway Interaction Database: KLK4
KEGG: KLK4
REACTOME: KLK4
Pathway Commons: KLK4
ContextiHOP: KLK4
ligand binding site mutation search in PubMed: KLK4
UCL Cancer Institute: KLK4
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for KLK4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H71A70TBLCA1
A226A226SBRCA1
L113P111HKIRC1
H40P39LLUAD1
L54E53KSKCM1
M161G159SSTAD1
G235V233MUCEC1
H71A70TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for KLK4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H71A70T-1.525274
G235V233M-1.4745709
A226A226S-0.79145141
L54E53K-0.77149898
L113P111H-0.59549823
M161G159S-0.56289737
H40P39L-0.002529335
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KLK4 from PDB

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Differential gene expression and gene-gene network for KLK4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KLK4 and the right PPI network was created from samples without mutations in the LBS of KLK4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for KLK4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for KLK4
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KLK4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of KLK4
Multiple alignments for Q9Y5K2 in multiple species
LBSAA sequence# speciesSpecies


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