mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SLK
Gene summary
Basic gene Info.Gene symbolSLK
Gene nameSTE20-like kinase
CytomapUCSC genome browser: 10q24.33
Type of geneprotein-coding
DescriptionCTCL tumor antigen se20-9Long Ste20-like KinaseSNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinaseSNF1 sucrose nonfermenting like kinaseSTE20-like serine/threonine-protein kinaseSTE20-related kinaseSTE20-
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000065613
HPRD : 11585
Vega : OTTHUMG00000018999
ProteinUniProt: Q9H2G2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLK
BioGPS: 9748
PathwayNCI Pathway Interaction Database: SLK
Pathway Commons: SLK
ContextiHOP: SLK
ligand binding site mutation search in PubMed: SLK
UCL Cancer Institute: SLK
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0046777protein autophosphorylation18239682

Ligand binding site mutations for SLK
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SLK
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SLK from PDB

Differential gene expression and gene-gene network for SLK
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SLK and the right PPI network was created from samples without mutations in the LBS of SLK. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SLK
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0236969Substance-Related Disorders1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SLK
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SLK go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SLK
Multiple alignments for Q9H2G2 in multiple species
LBSAA sequence# speciesSpecies
A112LIEFCAGGAVD3Homo sapiens, Mus musculus, Rattus norvegicus
A115FCAGGAVDAVM3Homo sapiens, Mus musculus, Rattus norvegicus
A172GDIKLADFGVS3Homo sapiens, Mus musculus, Rattus norvegicus
A61TNVLAAAKVID2Mus musculus, Rattus norvegicus
A61TSVLAAAKVID1Homo sapiens
C111ILIEFCAGGAV3Homo sapiens, Mus musculus, Rattus norvegicus
D173DIKLADFGVSA3Homo sapiens, Mus musculus, Rattus norvegicus
E109LWILIEFCAGG3Homo sapiens, Mus musculus, Rattus norvegicus
F110WILIEFCAGGA3Homo sapiens, Mus musculus, Rattus norvegicus
F174IKLADFGVSAK3Homo sapiens, Mus musculus, Rattus norvegicus
F45LGDGAFGKVYK3Homo sapiens, Mus musculus, Rattus norvegicus
G114EFCAGGAVDAV3Homo sapiens, Mus musculus, Rattus norvegicus
I106ENNLWILIEFC3Homo sapiens, Mus musculus, Rattus norvegicus
I108NLWILIEFCAG3Homo sapiens, Mus musculus, Rattus norvegicus
K63VLAAAKVIDTK3Homo sapiens, Mus musculus, Rattus norvegicus
L162KAGNILFTLDG3Homo sapiens, Mus musculus, Rattus norvegicus
L40EIIGELGDGAF3Homo sapiens, Mus musculus, Rattus norvegicus
L83VEIDILASCDH3Homo sapiens, Mus musculus, Rattus norvegicus
N160DLKAGNILFTL3Homo sapiens, Mus musculus, Rattus norvegicus
V48GAFGKVYKAQN3Homo sapiens, Mus musculus, Rattus norvegicus

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