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mutLBSgeneDB |
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| Gene summary for XYLB |
 Gene summary |
| Basic gene Info. | Gene symbol | XYLB |
| Gene name | xylulokinase homolog (H. influenzae) | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 3p22-p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005108.3, | |
| Description | xylulose kinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604049 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000093217 | ||
| HPRD : 06812 | ||
| Vega : OTTHUMG00000131294 | ||
| Protein | UniProt: O75191 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_XYLB | |
| BioGPS: 9942 | ||
| Pathway | NCI Pathway Interaction Database: XYLB | |
| KEGG: XYLB | ||
| REACTOME: XYLB | ||
| Pathway Commons: XYLB | ||
| Context | iHOP: XYLB | |
| ligand binding site mutation search in PubMed: XYLB | ||
| UCL Cancer Institute: XYLB | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0005997 | xylulose metabolic process | 23179721 | GO:0046835 | carbohydrate phosphorylation | 23179721 |
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| Ligand binding site mutations for XYLB |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | N445 | R446S | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for XYLB |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | N445 | R446S | -0.68240384 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for XYLB from PDB |
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| Differential gene expression and gene-gene network for XYLB |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for XYLB |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for XYLB |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of XYLB go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 4bc2 | A | N445 | ADP | ADP | 4bc2 | B | N445 | ADP | ADP | 4bc2 | C | N445 |
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| Conservation information for LBS of XYLB |
| Multiple alignments for O75191 in multiple species |
| LBS | AA sequence | # species | Species | A442 | LATGGASHNKD | 2 | Mus musculus, Rattus norvegicus | A442 | LATGGASHNRE | 1 | Homo sapiens | A442 | LVTGGASRNTV | 1 | Caenorhabditis elegans | A442 | LATGGASHNRD | 1 | Bos taurus | D280 | VAFTGDNPASL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D280 | LPFLGDNPSSL | 1 | Caenorhabditis elegans | D280 | VAFSGDNPASL | 1 | Mus musculus | E344 | GSLMREKIRDE | 3 | Mus musculus, Rattus norvegicus, Bos taurus | E344 | GSLMREKIRNE | 1 | Homo sapiens | E344 | GSLTRERARNL | 1 | Caenorhabditis elegans | G300 | IAVSLGTSDTL | 3 | Homo sapiens, Mus musculus, Bos taurus | G300 | IGISLGTSDTV | 1 | Caenorhabditis elegans | G300 | VAVSLGTSDTL | 1 | Rattus norvegicus | G441 | ILATGGASHNR | 2 | Homo sapiens, Bos taurus | G441 | ILATGGASHNK | 2 | Mus musculus, Rattus norvegicus | G441 | ILVTGGASRNT | 1 | Caenorhabditis elegans | H444 | TGGASHNKDIL | 2 | Mus musculus, Rattus norvegicus | H444 | TGGASHNREIL | 1 | Homo sapiens | H444 | TGGASRNTVLL | 1 | Caenorhabditis elegans | H444 | TGGASHNRDIL | 1 | Bos taurus | H99 | GAGQQHGSVYW | 3 | Mus musculus, Rattus norvegicus, Bos taurus | H99 | GAGQQHGSIYW | 1 | Homo sapiens | H99 | GCAQQHGTVYW | 1 | Caenorhabditis elegans | I448 | SHNKDILQVLA | 2 | Mus musculus, Rattus norvegicus | I448 | SHNREILQVLA | 1 | Homo sapiens | I448 | SRNTVLLQILS | 1 | Caenorhabditis elegans | I448 | SHNRDILQVLA | 1 | Bos taurus | N281 | AFTGDNPASLA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | N281 | PFLGDNPSSLA | 1 | Caenorhabditis elegans | N281 | AFSGDNPASLA | 1 | Mus musculus | N445 | GGASHNKDILQ | 2 | Mus musculus, Rattus norvegicus | N445 | GGASHNREILQ | 1 | Homo sapiens | N445 | GGASRNTVLLQ | 1 | Caenorhabditis elegans | N445 | GGASHNRDILQ | 1 | Bos taurus | Q97 | LSGAGQQHGSV | 3 | Mus musculus, Rattus norvegicus, Bos taurus | Q97 | LSGAGQQHGSI | 1 | Homo sapiens | Q97 | ISGCAQQHGTV | 1 | Caenorhabditis elegans | Q98 | SGAGQQHGSVY | 3 | Mus musculus, Rattus norvegicus, Bos taurus | Q98 | SGAGQQHGSIY | 1 | Homo sapiens | Q98 | SGCAQQHGTVY | 1 | Caenorhabditis elegans | R170 | SRAYERFTGNQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R170 | SRAHHRFSAAQ | 1 | Caenorhabditis elegans | S340 | CFKNGSLMREK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S340 | CFKNGSLTRER | 1 | Caenorhabditis elegans | T301 | AVSLGTSDTLF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T301 | GISLGTSDTVF | 1 | Caenorhabditis elegans | W137 | SDCPIWMDSST | 2 | Mus musculus, Rattus norvegicus | W137 | SDCPVWMDSST | 1 | Homo sapiens | W137 | QKSPIWMDSST | 1 | Caenorhabditis elegans | W137 | SNCPVWMDSST | 1 | Bos taurus | W355 | SASCSWNKFSK | 2 | Mus musculus, Rattus norvegicus | W355 | SVSRSWSDFSK | 1 | Homo sapiens | W355 | NNSS-WDKWDK | 1 | Caenorhabditis elegans | W355 | SASGSWSKFSK | 1 | Bos taurus |
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