| Disease | Alzheimer's disease |
|---|---|
| Definition | A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. |
| Synonym |
|
| Cross reference |
OLS4 MedGen GARD Disease ontology Alliance of genome resources OMIM® |
| Disease | Parkinson's disease |
|---|---|
| Definition | A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression. |
| Synonym |
|
| Cross reference |
OLS4 MedGen GARD Disease ontology Alliance of genome resources OMIM® |
| Disease | Multiple sclerosis |
|---|---|
| Definition | A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals. |
| Synonym |
|
| Cross reference |
OLS4 MedGen GARD Disease ontology Alliance of genome resources OMIM® |