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  Cerebral Cortex GW23.5

Overall Design16 Bulk Tissue Samples from GW13-23; 226 Single Cells from GW19.5-23.5
SummaryLong non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and diseasee. LncRNAs exhibit cell type- and tissue-specific expression, but little is known about the expression and function of lncRNAs in the developing human brain. Here, we deeply profiled lncRNAs from polyadenylated and total RNA obtained from human neocortex at different stages of development and integrated this resource to analyze the transcriptomes of single cells. While lncRNAs were generally detected at low levels in whole tissues, single cell transcriptomics revealed that many lncRNAs are abundantly expressed in individual cells and are cell type-specific. Furthermore, we used CRISRPi to show that LOC646329, a lncRNA enriched in radial glia but detected at low abundance in tissues, regulates cell proliferation. The discrete and abundant expression of lncRNAs among individual cells has important implications for both their biological function and utility for distinguishing neural cell types.
Dataset viewGSE71315
PMID27081004

Samples in Cerebral Cortex GW23.5

Displaying 71-77 of 77 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE71315GSM1832579Illumina HiSeq 2500Homo sapiensS46.H10Cerebral Cortex GW23.5
GSE71315GSM1832580Illumina HiSeq 2500Homo sapiensS46.H2Cerebral Cortex GW23.5
GSE71315GSM1832581Illumina HiSeq 2500Homo sapiensS46.H3Cerebral Cortex GW23.5
GSE71315GSM1832582Illumina HiSeq 2500Homo sapiensS46.H5Cerebral Cortex GW23.5
GSE71315GSM1832583Illumina HiSeq 2500Homo sapiensS46.H7Cerebral Cortex GW23.5
GSE71315GSM1832584Illumina HiSeq 2500Homo sapiensS46.H8Cerebral Cortex GW23.5
GSE71315GSM1832585Illumina HiSeq 2500Homo sapiensS46.H9Cerebral Cortex GW23.5

Gene rank in Cerebral Cortex GW23.5

Displaying 1-10 of 12884 results.
Rank orderGene SymbolEnsembl ID
1MALAT1ENSG00000251562
2MAP1BENSG00000131711
3SOX4ENSG00000124766
4TUBA1AENSG00000167552
5SOX11ENSG00000176887
6DPYSL2ENSG00000092964
7DCXENSG00000077279
8MT-CO1ENSG00000198804
9STMN1ENSG00000117632
10HSP90AA1ENSG00000080824