Loading

Cell View

Cell Information

  PDX, LC-MBT-15

Overall DesignWe performed single-cell RNA sequencing (scRNA-Seq) together with bulk sequencing by applying Smart-Seq protocol (Ramsköld et al., Nat Biotechnol 2012). Enrichment of cancer cells in PDX from primary tumor (LC-PT-45: bulk RNA-Seq, n=1) was identified by histopathological examination and genomic signatures. Tumor cell-enriched PDX cells (LC-PT-45: scRNA-Seq, n=34; bulk RNA-Seq, n=9) were analyzed, and additional batch (LC-Pt-45-Re: scRNA-Seq, n=43; bulk RNA-Seq, n=7) was obtained to check comparable results. H358 human lung cancer cells (scRNA-Seq, n=50; bulk RNA-Seq, n=1) were used as cell line controls. Another lung cancer PDX case (LC-MBT-15: scRNA-Seq, n=49; bulk RNA-Seq, n=7) was prepared to validate our analytical strategy applied in the LC-PT-45 case.
SummaryTo address how intratumoral heterogeneity affects anti-cancer drug responses, we profiled transcriptomes of single cancer cells originating from lung adenocarcinoma patient-derived xenograft (PDX) tumors.
Dataset viewGSE69405
PMID26084335

Samples in PDX, LC-MBT-15

Displaying 1-10 of 49 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE69405GSM1702735Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC02PDX, LC-MBT-15
GSE69405GSM1702736Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC07PDX, LC-MBT-15
GSE69405GSM1702737Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC08PDX, LC-MBT-15
GSE69405GSM1702738Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC09PDX, LC-MBT-15
GSE69405GSM1702739Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC10PDX, LC-MBT-15
GSE69405GSM1702740Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC11PDX, LC-MBT-15
GSE69405GSM1702741Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC14PDX, LC-MBT-15
GSE69405GSM1702742Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC15PDX, LC-MBT-15
GSE69405GSM1702743Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC16PDX, LC-MBT-15
GSE69405GSM1702744Illumina HiSeq 2500Homo sapiensLC-MBT-15_SC20PDX, LC-MBT-15

Gene rank in PDX, LC-MBT-15

Displaying 1-10 of 29762 results.
Rank orderGene SymbolEnsembl ID
1MT-CO2ENSG00000198712
2FTLENSG00000087086
3MT-ATP6ENSG00000198899
4B2MENSG00000166710
5MT-RNR2ENSG00000210082
6TMSB4XENSG00000205542
7EEF1A1ENSG00000156508
8RPL41ENSG00000229117
9MT-CO3ENSG00000198938
10RPS18ENSG00000096150