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  glioblastoma [Cla]

Overall DesignOperative specimens from five glioblastoma patients (MGH26, MGH28, MGH29, MGH30, MGH31) were acutely dissociated, depleted for CD45+ inflammatory cells and then sorted as single cells (576 samples). Population controls for each tumor were isolated by sorting 2000-10000 cells and processed in parallel (5 population control samples). Single cells from two established cell lines, GBM6 and GBM8, were also sorted as single cells (192 samples).
SummaryWe report transcriptomes from 430 single glioblastoma cells isolated from 5 individual tumors and 102 single cells from gliomasphere cells lines generated using SMART-seq. In addition, we report population RNA-seq from the five tumors as well as RNA-seq from cell lines derived from 3 tumors (MGH26, MGH28, MGH31) cultured under serum free (GSC) and differentiated (DGC) conditions. This dataset highlights intratumoral heterogeneity with regards to the expression of de novo derived transcriptional modules and established subtype classifiers.
Dataset viewGSE57872
PMID24925914

Samples in glioblastoma [Cla]

Displaying 1-10 of 45 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE57872GSM1395441Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_D07glioblastoma [Cla]
GSE57872GSM1395458Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_E12glioblastoma [Cla]
GSE57872GSM1395476Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_G06glioblastoma [Cla]
GSE57872GSM1395479Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_G09glioblastoma [Cla]
GSE57872GSM1395482Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_G12glioblastoma [Cla]
GSE57872GSM1395496Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26-2_A02glioblastoma [Cla]
GSE57872GSM1395526Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26-2_C08glioblastoma [Cla]
GSE57872GSM1395558Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26-2_F04glioblastoma [Cla]
GSE57872GSM1395567Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26-2_G01glioblastoma [Cla]
GSE57872GSM1395578Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26-2_G12glioblastoma [Cla]

Gene rank in glioblastoma [Cla]

Displaying 11-20 of 5942 results.
Rank orderGene SymbolEnsembl ID
11SLC1A3ENSG00000079215
12FOSENSG00000170345
13HSPA8ENSG00000109971
14UBCENSG00000150991
15ALDOAENSG00000149925
16H3F3BENSG00000132475
17MAP1BENSG00000131711
18ENO1ENSG00000074800
19CALM2ENSG00000143933
20MT-CYBENSG00000198727