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  glioblastoma [Pro+Cla]

Overall DesignOperative specimens from five glioblastoma patients (MGH26, MGH28, MGH29, MGH30, MGH31) were acutely dissociated, depleted for CD45+ inflammatory cells and then sorted as single cells (576 samples). Population controls for each tumor were isolated by sorting 2000-10000 cells and processed in parallel (5 population control samples). Single cells from two established cell lines, GBM6 and GBM8, were also sorted as single cells (192 samples).
SummaryWe report transcriptomes from 430 single glioblastoma cells isolated from 5 individual tumors and 102 single cells from gliomasphere cells lines generated using SMART-seq. In addition, we report population RNA-seq from the five tumors as well as RNA-seq from cell lines derived from 3 tumors (MGH26, MGH28, MGH31) cultured under serum free (GSC) and differentiated (DGC) conditions. This dataset highlights intratumoral heterogeneity with regards to the expression of de novo derived transcriptional modules and established subtype classifiers.
Dataset viewGSE57872
PMID24925914

Samples in glioblastoma [Pro+Cla]

Displaying 1-10 of 20 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE57872GSM1395401Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_A03glioblastoma [Pro+Cla]
GSE57872GSM1395403Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_A05glioblastoma [Pro+Cla]
GSE57872GSM1395411Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_B01glioblastoma [Pro+Cla]
GSE57872GSM1395425Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_C03glioblastoma [Pro+Cla]
GSE57872GSM1395434Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_C12glioblastoma [Pro+Cla]
GSE57872GSM1395435Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_D01glioblastoma [Pro+Cla]
GSE57872GSM1395450Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_E04glioblastoma [Pro+Cla]
GSE57872GSM1395468Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_F10glioblastoma [Pro+Cla]
GSE57872GSM1395508Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26-2_B02glioblastoma [Pro+Cla]
GSE57872GSM1395511Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26-2_B05glioblastoma [Pro+Cla]

Gene rank in glioblastoma [Pro+Cla]

Displaying 11-20 of 5942 results.
Rank orderGene SymbolEnsembl ID
11B2MENSG00000166710
12TPI1ENSG00000111669
13DDX5ENSG00000108654
14ATP5BENSG00000110955
15TMBIM6ENSG00000139644
16CALM2ENSG00000143933
17ALDOAENSG00000149925
18ENO1ENSG00000074800
19HNRNPA2B1ENSG00000122566
20TMEM45AENSG00000181458