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  hES hiPS-derived neuron

Overall DesignPatch-Seq of 20 hESC/hiPSC-derived neurons.
SummaryThe mammalian brain is heterogeneous, containing billions of neurons and trillions of synapses forming various neural circuitries, through which sense, movement, thought, and emotion are generated. The cellular heterogeneity of the brain has made it difficult to study the molecular logic of neural circuitry wiring, pruning, activation, and plasticity, until recently, transcriptome analyses with single-cell resolution makes decoding of gene regulatory networks underlying aforementioned circuitry properties possible. Here, we report success in performing both electrophysiological and whole-genome transcriptome analyses on single human neurons in culture. Using Weighted Gene Coexpression Network Analyses (WGCNA), we identified gene clusters highly correlated with neuronal maturation judged by electrophysiological characteristics. A tight link between neuronal maturation and genes involved in ubiquitination and mitochondrial function was revealed. Moreover, we identified a list of candidate genes, which could potentially serve as biomarkers for neuronal maturation. Coupled electrophysiological recording and single-cell transcriptome analysis will serve as powerful tools in the future to unveil molecular logics for neural circuitry functions.
Dataset viewGSE77564
PMID26883038

Samples in hES hiPS-derived neuron

Displaying 11-20 of 20 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE77564GSM2054554Illumina HiSeq 2500Homo sapiensSingle neuron 11hES hiPS-derived neuron
GSE77564GSM2054555Illumina HiSeq 2500Homo sapiensSingle neuron 12hES hiPS-derived neuron
GSE77564GSM2054556Illumina HiSeq 2500Homo sapiensSingle neuron 13hES hiPS-derived neuron
GSE77564GSM2054557Illumina HiSeq 2500Homo sapiensSingle neuron 14hES hiPS-derived neuron
GSE77564GSM2054558Illumina HiSeq 2500Homo sapiensSingle neuron 15hES hiPS-derived neuron
GSE77564GSM2054559Illumina HiSeq 2500Homo sapiensSingle neuron 16hES hiPS-derived neuron
GSE77564GSM2054560Illumina HiSeq 2500Homo sapiensSingle neuron 17hES hiPS-derived neuron
GSE77564GSM2054561Illumina HiSeq 2500Homo sapiensSingle neuron 18hES hiPS-derived neuron
GSE77564GSM2054562Illumina HiSeq 2500Homo sapiensSingle neuron 19hES hiPS-derived neuron
GSE77564GSM2054563Illumina HiSeq 2500Homo sapiensSingle neuron 20hES hiPS-derived neuron

Gene rank in hES hiPS-derived neuron

Displaying 19191-19200 of 19234 results.
Rank orderGene SymbolEnsembl ID
19191STEAP3-AS1ENSG00000229867
19192SERPINB13ENSG00000197641
19193C3orf67ENSG00000163689
19194RIMBP3BENSG00000274600
19195LINC01164ENSG00000189275
19196KIAA0196ENSG00000164961
19197GALNT3ENSG00000115339
19198FAM153BENSG00000182230
19199KCNJ8ENSG00000121361
19200LGR5ENSG00000139292