Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1843

Name

DUSP1

Synonym

CL100|HVH1|MKP-1|MKP1|PTPN10;dual specificity phosphatase 1;DUSP1;dual specificity phosphatase 1

Definition

MAP kinase phosphatase 1|dual specificity protein phosphatase 1|dual specificity protein phosphatase hVH1|mitogen-activated protein kinase phosphatase 1|protein-tyrosine phosphatase CL100|serine/threonine specific protein phosphatase

Position

5q34

Gene Type

protein-coding

PAH Type

Description

PH

Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.
More detail of all Mouse literatures about DUSP1

Pathways and Diseases

Pathway

Regulation of p38-alpha and p38-beta;PID Curated;200054

Pathway

nfkb activation by nontypeable hemophilus influenzae;PID BioCarta;100088

Pathway

mechanism of gene regulation by peroxisome proliferators via ppara;PID BioCarta;100066

Pathway

Direct p53 effectors;PID Curated;200101

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

ErbB1 downstream signaling;PID Curated;200113

Pathway

Fc-epsilon receptor I signaling in mast cells;PID Curated;200003

Pathway

Oxidative stress response;PANTHER;P00046

Pathway

AP-1 transcription factor network;PID Curated;200118

Pathway

ATF-2 transcription factor network;PID Curated;200116

Disease

Renal Cell cancer;FunDO

Disease

Heart failure;FunDO

Disease

Osteomyelitis;FunDO

Disease

Rheumatic fever;FunDO

Disease

Liver tumor;FunDO

Disease

Vitamin D deficiency;FunDO

Disease

Bladder cancer;FunDO

Disease

Neuroblastoma;FunDO

Disease

Ovary cancer;FunDO

Disease

Breast cancer;FunDO

Disease

Stomach cancer;FunDO

Disease

Depression;FunDO

Disease

Liver cancer;FunDO

External Links

Links to Entrez Gene

1843

Links to all GeneRIF Items

1843

Links to iHOP

1843

Sequence Information

Nucleotide Sequence

>1843 : length: 1104
atggtcatggaagtgggcaccctggacgctggaggcctgcgggcgctgctgggggagcga
gcggcgcaatgcctgctgctggactgccgctccttcttcgctttcaacgccggccacatc
gccggctctgtcaacgtgcgcttcagcaccatcgtgcggcgccgggccaagggcgccatg
ggcctggagcacatcgtgcccaacgccgagctccgcggccgcctgctggccggcgcctac
cacgccgtggtgttgctggacgagcgcagcgccgccctggacggcgccaagcgcgacggc
accctggccctggcggccggcgcgctctgccgcgaggcgcgcgccgcgcaagtcttcttc
ctcaaaggaggatacgaagcgttttcggcttcctgcccggagctgtgcagcaaacagtcg
acccccatggggctcagccttcccctgagtactagcgtccctgacagcgcggaatctggg
tgcagttcctgcagtaccccactctacgatcagggtggcccggtggaaatcctgcccttt
ctgtacctgggcagtgcgtatcacgcttcccgcaaggacatgctggatgccttgggcatc
actgccttgatcaacgtctcagccaattgtcccaaccattttgagggtcactaccagtac
aagagcatccctgtggaggacaaccacaaggcagacatcagctcctggttcaacgaggcc
attgacttcatagactccatcaagaatgctggaggaagggtgtttgtccactgccaggca
ggcatttcccggtcagccaccatctgccttgcttaccttatgaggactaatcgagtcaag
ctggacgaggcctttgagtttgtgaagcagaggcgaagcatcatctctcccaacttcagc
ttcatgggccagctgctgcagtttgagtcccaggtgctggctccgcactgttcggcagag
gctgggagccccgccatggctgtgctcgaccgaggcacctccaccaccaccgtgttcaac
ttccccgtctccatccctgtccactccacgaacagtgcgctgagctaccttcagagcccc
attacgacctctcccagctgctga

Protein Sequence

>1843 : length: 367
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC



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