| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 240 |
Name | ALOX5 |
Synonym | 5-LO|5-LOX|5LPG|LOG5;arachidonate 5-lipoxygenase;ALOX5;arachidonate 5-lipoxygenase |
Definition | LOX-5|arachidonic 5-lipoxygenase alpha-10 isoform|arachidonic 5-lipoxygenase delta-10-13 isoform|arachidonic 5-lipoxygenase delta-13 isoform|arachidonic 5-lipoxygenase delta-p10 isoform|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase |
Position | 10q11.2 |
Gene Type | protein-coding |
|
PAH Type |
Description |
HPH | Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. |
| More detail of all Rat literatures about ALOX5 | |
|
Pathways and Diseases |
|
Pathway | Leukotriene synthesis;PID Reactome;500771 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | eicosanoid metabolism;PID BioCarta;100180 |
Pathway | leukotriene biosynthesis;BioCyc;PWY66-375 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Arachidonic acid metabolism;KEGG PATHWAY;hsa00590 |
Disease | CANCER;GAD |
Disease | IMMUNE;GAD |
Disease | vascular disease;GAD |
Disease | Tuberculosis;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Asthma, diminished response to antileukotriene treatment in;OMIM |
Disease | PHARMACOGENOMIC;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Cytomegalovirus infection;FunDO |
Disease | Hematological and biochemical traits;NHGRI |
Disease | Asthma;FunDO |
Disease | Cancer;FunDO |
Disease | Dental plaque;FunDO |
Disease | Asthma;GAD |
Disease | colorectal cancer;GAD |
Disease | myocardial infarct;GAD |
Disease | Atherosclerosis, susceptibility to;OMIM |
Disease | Atherosclerosis;FunDO |
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External Links |
|
Links to Entrez Gene | 240 |
Links to all GeneRIF Items | 240 |
Links to iHOP | 240 |
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Sequence Information |
|
Nucleotide Sequence |
>240 : length: 2025 atgccctcctacacggtcaccgtggccactggcagccagtggttcgccggcactgacgac tacatctacctcagcctcgtgggctcggcgggctgcagcgagaagcacctgctggacaag cccttctacaacgacttcgagcgtggcgcggtggattcatacgacgtgactgtggacgag gaactgggcgagatccagctggtcagaatcgagaagcgcaagtactggctgaatgacgac tggtacctgaagtacatcacgctgaagacgccccacggggactacatcgagttcccctgc taccgctggatcaccggcgatgtcgaggttgtcctgagggatggacgcgcaaagttggcc cgagatgaccaaattcacattctcaagcaacaccgacgtaaagaactggaaacacggcaa aaacaatatcgatggatggagtggaaccctggcttccccttgagcatcgatgccaaatgc cacaaggatttaccccgtgatatccagtttgatagtgaaaaaggagtggactttgttctg aattactccaaagcgatggagaacctgttcatcaaccgcttcatgcacatgttccagtct tcttggaatgacttcgccgactttgagaaaatctttgtcaagatcagcaacactatttct gagcgggtcatgaatcactggcaggaagacctgatgtttggctaccagttcctgaatggc tgcaaccctgtgttgatccggcgctgcacagagctgcccgagaagctcccggtgaccacg gagatggtagagtgcagcctggagcggcagctcagcttggagcaggaggtccagcaaggg aacattttcatcgtggactttgagctgctggatggcatcgatgccaacaaaacagacccc tgcacactccagttcctggccgctcccatctgcttgctgtataagaacctggccaacaag attgtccccattgccatccagctcaaccaaatcccgggagatgagaaccctattttcctc ccttcggatgcaaaatacgactggcttttggccaaaatctgggtgcgttccagtgacttc cacgtccaccagaccatcacccaccttctgcgaacacatctggtgtctgaggtttttggc attgcaatgtaccgccagctgcctgctgtgcaccccattttcaagctgctggtggcacac gtgagattcaccattgcaatcaacaccaaggcccgtgagcagctcatctgcgagtgtggc ctctttgacaaggccaacgccacagggggcggtgggcacgtgcagatggtgcagagggcc atgaaggacctgacctatgcctccctgtgctttcccgaggccatcaaggcccggggcatg gagagcaaagaagacatcccctactacttctaccgggacgacgggctcctggtgtgggaa gccatcaggacgttcacggccgaggtggtagacatctactacgagggcgaccaggtggtg gaggaggacccggagctgcaggacttcgtgaacgatgtctacgtgtacggcatgcggggc cgcaagtcctcaggcttccccaagtcggtcaagagccgggagcagctgtcggagtacctg accgtggtgatcttcaccgcctccgcccagcacgccgcggtcaacttcggccagtacgac tggtgctcctggatccccaatgcgcccccaaccatgcgagccccgccaccgactgccaag ggcgtggtgaccattgagcagatcgtggacacgctgcccgaccgcggccgctcctgctgg catctgggtgcagtgtgggcgctgagccagttccaggaaaacgagctgttcctgggcatg tacccagaagagcattttatcgagaagcctgtgaaggaagccatggcccgattccgcaag aacctcgaggccattgtcagcgtgattgctgagcgcaacaagaagaagcagctgccatat tactacttgtccccagaccggattccgaacagtgtggccatctga |
Protein Sequence |
>240 : length: 674 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLA RDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNG CNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDP CTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDF HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWE AIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYL TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPY YYLSPDRIPNSVAI |