| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3099 |
Name | HK2 |
Synonym | HKII|HXK2;hexokinase 2;HK2;hexokinase 2 |
Definition | HK II|hexokinase type II|hexokinase-2|hexokinase-2, muscle|muscle form hexokinase |
Position | 2p13 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | The activation of the hexokinase-2/hypoxia-inducible factor-1alpha axis appears to be the key mediator for neointimal lesion formation in a model of pulmonary arterial hypertension. |
PAH | The activation of the hexokinase-2/hypoxia-inducible factor-1alpha axis appears to be the key mediator for neointimal lesion formation in a model of pulmonary arterial hypertension. |
| More detail of all Rat literatures about HK2 | |
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Pathways and Diseases |
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Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Starch and sucrose metabolism;KEGG PATHWAY;hsa00500 |
Pathway | Butirosin and neomycin biosynthesis;KEGG PATHWAY;hsa00524 |
Pathway | starch degradation;BioCyc;PWY-842 |
Pathway | Amino sugar and nucleotide sugar metabolism;KEGG PATHWAY;hsa00520 |
Pathway | Galactose metabolism;KEGG PATHWAY;hsa00052 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Fructose and mannose metabolism;KEGG PATHWAY;hsa00051 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | Carbohydrate digestion and absorption;KEGG PATHWAY;hsa04973 |
Pathway | Transmembrane transport of small molecules;Reactome;REACT:15518 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Pathway | Glycolysis / Gluconeogenesis;KEGG PATHWAY;hsa00010 |
Pathway | Metabolism of carbohydrates;Reactome;REACT:474 |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 3099 |
Links to all GeneRIF Items | 3099 |
Links to iHOP | 3099 |
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Sequence Information |
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Nucleotide Sequence |
>3099 : length: 2754 atgattgcctcgcatctgcttgcctacttcttcacggagctcaaccatgaccaagtgcag aaggttgaccagtatctctaccacatgcgcctctctgatgagaccctcttggagatctct aagcggttccgcaaggagatggagaaagggcttggagccaccactcaccctactgcagca gtgaagatgctgcccacctttgtgaggtccactccagatgggacagaacacggagagttc ctggctctggatcttggagggaccaacttccgtgtgctttgggtgaaagtaacggacaat gggctccagaaggtggagatggagaatcagatctatgccatccctgaggacatcatgcga ggcagtggcacccagctgtttgaccacattgccgaatgcctggctaacttcatggataag ctacaaatcaaagacaagaagctcccactgggttttaccttctcgttcccctgccaccag actaaactagacgagagtttcctggtctcatggaccaagggattcaagtccagtggagtg gaaggcagagacgttgtggctctgatccggaaggccatccagaggagaggggactttgat atcgacattgtggctgtggtgaatgacacagttgggaccatgatgacctgtggttatgat gaccacaactgtgagattggtctcattgtgggcacgggcagcaacgcctgctacatggaa gagatgcgccacatcgacatggtggaaggcgatgaggggcggatgtgtatcaatatggag tggggggccttcggggacgatggctcgctcaacgacattcgcactgagtttgaccaggag attgacatgggctcactgaacccgggaaagcaactgtttgagaagatgatcagtgggatg tacatgggggagctggtgaggcttatcctggtgaagatggccaaggaggagctgctcttt ggggggaagctcagcccagagcttctcaacaccggtcgctttgagaccaaagacatctca gacattgaaggggagaaggatggcatccggaaggcccgtgaggtcctgatgcggttgggc ctggacccgactcaggaggactgcgtggccactcaccggatctgccagatcgtgtccaca cgctccgccagcctgtgcgcagccaccctggccgccgtgctgcagcgcatcaaggagaac aaaggcgaggagcggctgcgctctactattggggtcgacggttccgtctacaagaaacac ccccattttgccaagcgtctacataagaccgtgcggcggctggtgcccggctgcgatgtc cgcttcctccgctccgaggatggcagtggcaaaggtgcagccatggtgacagcagtggct taccggctggccgatcaacaccgtgcccgccagaagacattagagcatctgcagctgagc catgaccagctgctggaggtcaagaggaggatgaaggtagaaatggagcgaggtctgagc aaggagactcatgccagtgcccccgtcaagatgctgcccacctacgtgtgtgctaccccg gacggcacagagaaaggggacttcttggccttggaccttggaggaacaaatttccgggtc ctgctggtccgtgttcggaatgggaagtggggtggagtggagatgcacaacaagatctac gccatcccgcaggaggtcatgcacggcaccggggacgagctctttgaccacattgtccag tgcatcgcggacttcctcgagtacatgggcatgaagggcgtgtccctgcctctgggtttt accttctccttcccctgccagcagaacagcctggacgagagcatcctcctcaagtggaca aaaggcttcaaggcatctggctgcgagggcgaggacgtggtgaccctgctgaaggaagcg atccaccggcgagaggagtttgacctggatgtggttgctgtggtgaacgacacagtcgga actatgatgacctgtggctttgaagaccctcactgtgaagttggcctcattgttggcacg ggcagcaatgcctgctacatggaggagatgcgcaacgtggaactggtggaaggagaagag gggcggatgtgtgtgaacatggaatggggggccttcggggacaatggatgcctagatgac ttccgcacagaatttgatgtggctgtggatgagctttcactcaaccccggcaagcagagg ttcgagaaaatgatcagtggaatgtacctgggtgagattgtccgtaacattctcatcgat ttcaccaagcgtggactactcttccgaggccgcatctcagagcggctcaagacaaggggc atctttgaaaccaagttcttgtctcagattgagagtgactgcctggccctgctgcaagtc cgagccatcctgcaacacttagggcttgagagcacctgtgacgacagcatcattgttaag gaggtgtgcactgtggtggcccggcgggcagcccagctctgtggcgcaggcatggccgct gtggtggacaggatacgagaaaaccgtgggctggacgctctcaaagtgacagtgggtgtg gatgggaccctctacaagctacatcctcactttgccaaagtcatgcatgagacagtgaag gacctggctccgaaatgtgatgtgtctttcctgcagtcagaggatggcagcgggaagggg gcggcgctcatcactgctgtggcctgccgcatccgtgaggctggacagcgatag |
Protein Sequence |
>3099 : length: 917 MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG AALITAVACRIREAGQR |