| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 5165 |
Name | PDK3 |
Synonym | -;pyruvate dehydrogenase kinase, isozyme 3;PDK3;pyruvate dehydrogenase kinase, isozyme 3 |
Definition | pyruvate dehydrogenase kinase, isoenzyme 3|pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial |
Position | Xp22.11 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "Pyruvate dehydrogenase kinase (PDK) is pathologically activated in both conditions. This enzyme phosphorylates and inhibits pyruvate dehydrogenase (PDH). PDH catalyses the irreversible oxidation of pyruvate, yielding acetylCoA and CO2 and is a key enzyme controlling the rate of oxidative metabolism. PDK activation thus impairs the Krebs' cycle and creates a glycolytic shift in glucose metabolism. ". |
| More detail of all Human literatures about PDK3 | |
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Pathways and Diseases |
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Pathway | Pyruvate metabolism and Citric Acid (TCA) cycle;Reactome;REACT:1046 |
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External Links |
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Links to Entrez Gene | 5165 |
Links to all GeneRIF Items | 5165 |
Links to iHOP | 5165 |
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Sequence Information |
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Nucleotide Sequence |
>5165 : length: 1248 atgcggctgttccggtggctgctgaagcagccggtgcccaagcagatcgagcgctactcg cgcttttcgccgtcgccgctctccatcaaacaattcctggacttcgggagagataatgca tgtgagaaaacttcatatatgtttctacgaaaggaacttcctgtgcggctggctaacaca atgagagaagttaatcttctgccggataatttacttaaccgcccttcagtgggattggtt cagagttggtatatgcagagttttcttgaacttttagaatatgaaaataagagccctgag gatccacaggtcttggataactttctacaagttctgattaaagtcagaaatagacacaat gatgtggttcctacaatggcacaaggagtgattgaatacaaggagaagtttgggtttgat cctttcattagcactaacatccaatattttctggatcggttttataccaaccgcatctct ttccgcatgcttattaatcagcacacacttctgtttgggggtgacactaatcctgttcat cctaaacacataggaagtatcgatcccacctgtaacgtggcggatgtggtgaaagatgca tatgaaacagccaagatgctgtgtgaacagtattacctggtagctccagagctggaagtt gaagaattcaatgccaaagcgccagacaaacctattcaggtggtttatgtgccctcacat ctgtttcatatgctatttgagttgttcaagaactcaatgagagcgacagttgaactctat gaagacagaaaagagggctaccctgctgttaaaaccctcgttactttgggtaaagaagac ttatccattaagatcagtgacctaggtggtggtgtcccacttcgaaaaatagatcgtctt tttaactacatgtattctactgctcctagacccagcctggagcctaccagagctgcccct ttggctggatttggttatggtttgccaatttcccgtctgtatgctagatattttcaagga gatctgaaactgtattccatggaaggagtgggtactgatgctgtcatttatttgaaggct ctttcaagtgagtcatttgagagacttccagtttttaataagtccgcatggcgccattac aagaccacgcctgaagccgatgattggagcaatcccagcagtgaacccagggatgcttca aaatacaaagcaaaacaagacaagatcaagactaatagaactttctag |
Protein Sequence |
>5165 : length: 415 MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANT MREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHN DVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVH PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSH LFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRL FNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA LSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQDKIKTNRTF |