| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5166 |
Name | PDK4 |
Synonym | -;pyruvate dehydrogenase kinase, isozyme 4;PDK4;pyruvate dehydrogenase kinase, isozyme 4 |
Definition | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 4|pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial |
Position | 7q21.3 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | "Pyruvate dehydrogenase kinase (PDK) is pathologically activated in both conditions. This enzyme phosphorylates and inhibits pyruvate dehydrogenase (PDH). PDH catalyses the irreversible oxidation of pyruvate, yielding acetylCoA and CO2 and is a key enzyme controlling the rate of oxidative metabolism. PDK activation thus impairs the Krebs' cycle and creates a glycolytic shift in glucose metabolism. ". |
| More detail of all Human literatures about PDK4 | |
|
Pathways and Diseases |
|
Pathway | Pyruvate metabolism and Citric Acid (TCA) cycle;Reactome;REACT:1046 |
|
External Links |
|
Links to Entrez Gene | 5166 |
Links to all GeneRIF Items | 5166 |
Links to iHOP | 5166 |
|
Sequence Information |
|
Nucleotide Sequence |
>5166 : length: 1236 atgaaggcggcccgcttcgtgctgcgcagcgctggctcgctcaacggcgccggcctggtg ccccgagaggtggagcatttctcgcgctacagcccgtccccgctgtccatgaagcagcta ctggactttggttcagaaaatgcatgtgaaagaacttcttttgcatttttgcgacaagaa ttgcctgtgagactcgccaacattctgaaggaaattgatatcctcccgacccaattagta aatacctcttcagtgcaattggttaaaagctggtatatacagagcctgatggatttggtg gaattccatgagaaaagcccagatgaccagaaagcattatcagactttgtagatacactc atcaaagttcgaaatagacaccataatgtagtccctacaatggcacaaggaatcatagag tataaagatgcctgtacagttgacccagtcaccaatcaaaatcttcaatatttcttggat cgattttacatgaaccgtatttctactcggatgctgatgaaccagcacattcttatattt agtgactcacagacaggaaacccaagccacattggaagcattgatcctaactgtgatgtg gtagcagtggtccaagatgcctttgagtgttcaaggatgctctgtgatcagtattattta tcatctccagaattaaagcttacacaagtgaatggaaaatttccagaccaaccaattcac atcgtgtatgttccttctcacctccatcatatgctctttgaactatttaagaatgcaatg cgggcaacagttgaacaccaggaaaatcagccttcccttacaccaatagaggttattgtt gtcttgggaaaagaagaccttaccattaagatttcagacagaggaggtggtgttcccctg agaattattgaccgcctctttagttatacatactccactgcaccaacgcctgtgatggat aattcccggaatgctcctttggctggttttggttacggcttgccaatttctcgtctgtat gcaaagtactttcaaggagatctgaatctctactctttatcaggatatggaacagatgct atcatctacttaaaggctttgtcttctgagtctatagaaaaacttccagtttttaacaag tcagccttcaaacattatcagatgagctctgaggctgatgactggtgtatcccaagcagg gaaccaaagaacctggcaaaagaagtggccatgtga |
Protein Sequence |
>5166 : length: 411 MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF SDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIH IVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPL RIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDA IIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM |