| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5566 |
Name | PRKACA |
Synonym | PKACA;protein kinase, cAMP-dependent, catalytic, alpha;PRKACA;protein kinase, cAMP-dependent, catalytic, alpha |
Definition | PKA C-alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A catalytic subunit |
Position | 19p13.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Recent reports of elevated transient receptor potential (TRP) calcium channels TRP3 and TRP6 in PA SMCs from IPAH patients indicated that inhibition of these channels can repress the heightened proliferation observed in SMCs. Inhibition of PKA or activation of cAMP seem to have a similar effect. |
| More detail of all Human literatures about PRKACA | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Metabotropic glutamate receptor group III pathway;PANTHER;P00039 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Vibrio cholerae infection;KEGG PATHWAY;hsa05110 |
Pathway | Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction;PANTHER;P00028 |
Pathway | Metabotropic glutamate receptor group I pathway;PANTHER;P00041 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | GABA-B receptor II signaling;PANTHER;P05731 |
Pathway | Muscarinic acetylcholine receptor 2 and 4 signaling pathway;PANTHER;P00043 |
Pathway | Hedgehog signaling events mediated by Gli proteins;PID Curated;200147 |
Pathway | Transmembrane transport of small molecules;Reactome;REACT:15518 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | Loss of Nlp from mitotic centrosomes;PID Reactome;500384 |
Pathway | LKB1 signaling events;PID Curated;200061 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Metabotropic glutamate receptor group II pathway;PANTHER;P00040 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Olfactory transduction;KEGG PATHWAY;hsa04740 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Histamine H2 receptor mediated signaling pathway;PANTHER;P04386 |
Pathway | LPA4-mediated signaling events;PID Curated;200036 |
Pathway | 5HT1 type receptor mediated signaling pathway;PANTHER;P04373 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Taste transduction;KEGG PATHWAY;hsa04742 |
Pathway | DARPP-32 events;PID Reactome;500841 |
Pathway | Beta2 adrenergic receptor signaling pathway;PANTHER;P04378 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway;PANTHER;P00026 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Aurora A signaling;PID Curated;200166 |
Pathway | Calcium signaling in the CD4+ TCR pathway;PID Curated;200159 |
Pathway | Metabolism of carbohydrates;Reactome;REACT:474 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Prion diseases;KEGG PATHWAY;hsa05020 |
Pathway | Retinoic acid receptors-mediated signaling;PID Curated;200142 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | Signaling events mediated by HDAC Class I;PID Curated;200070 |
Pathway | Loss of proteins required for interphase microtubule organization from the centrosome;PID Reactome;500383 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Vasopressin-regulated water reabsorption;KEGG PATHWAY;hsa04962 |
Pathway | Beta1 adrenergic receptor signaling pathway;PANTHER;P04377 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | Hedgehog signaling pathway;KEGG PATHWAY;hsa04340 |
Pathway | Paxillin-dependent events mediated by a4b1;PID Curated;200117 |
Pathway | Gastric acid secretion;KEGG PATHWAY;hsa04971 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | Syndecan-1-mediated signaling events;PID Curated;200134 |
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External Links |
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Links to Entrez Gene | 5566 |
Links to all GeneRIF Items | 5566 |
Links to iHOP | 5566 |
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Sequence Information |
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Nucleotide Sequence |
>5566 : length: 1056 atgggcaacgccgccgccgccaagaagggcagcgagcaggagagcgtgaaagaattctta gccaaagccaaagaagattttcttaaaaaatgggaaagtcccgctcagaacacagcccac ttggatcagtttgaacgaatcaagaccctcggcacgggctccttcgggcgggtgatgctg gtgaaacacaaggagaccgggaaccactatgccatgaagatcctcgacaaacagaaggtg gtgaaactgaaacagatcgaacacaccctgaatgaaaagcgcatcctgcaagctgtcaac tttccgttcctcgtcaaactcgagttctccttcaaggacaactcaaacttatacatggtc atggagtacgtgcccggcggggagatgttctcacacctacggcggatcggaaggttcagt gagccccatgcccgtttctacgcggcccagatcgtcctgacctttgagtatctgcactcg ctggatctcatctacagggacctgaagccggagaatctgctcattgaccagcagggctac attcaggtgacagacttcggtttcgccaagcgcgtgaagggccgcacttggaccttgtgc ggcacccctgagtacctggcccctgagattatcctgagcaaaggctacaacaaggccgtg gactggtgggccctgggggttcttatctatgaaatggccgctggctacccgcccttcttc gcagaccagcccatccagatctatgagaagatcgtctctgggaaggtgcgcttcccttcc cacttcagctctgacttgaaggacctgctgcggaacctcctgcaggtagatctcaccaag cgctttgggaacctcaagaatggggtcaacgatatcaagaaccacaagtggtttgccaca actgactggattgccatctaccagaggaaggtggaagctcccttcataccaaagtttaaa ggccctggggatacgagtaactttgacgactatgaggaagaagaaatccgggtctccatc aatgagaagtgtggcaaggagttttctgagttttag |
Protein Sequence |
>5566 : length: 351 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF |