Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6648

Name

SOD2

Synonym

IPOB|MNSOD|MVCD6;superoxide dismutase 2, mitochondrial;SOD2;superoxide dismutase 2, mitochondrial

Definition

Mn superoxide dismutase|indophenoloxidase B|manganese-containing superoxide dismutase|mangano-superoxide dismutase|superoxide dismutase [Mn], mitochondrial

Position

6q25.3

Gene Type

protein-coding

PAH Type

Description

PAH

"In a porcine PPHN model, combined therapy with BH4 and a superoxide dismutase mimetic (which enhances survival of endogenous NO) restores endothelial function."
More detail of all Human literatures about SOD2

Pathways and Diseases

Pathway

erythropoietin mediated neuroprotection through nf-kb;PID BioCarta;100176

Pathway

Huntington's disease;KEGG PATHWAY;hsa05016

Pathway

superoxide radicals degradation;BioCyc;DETOX1-PWY

Pathway

FoxO family signaling;PID Curated;200091

Pathway

Peroxisome;KEGG PATHWAY;hsa04146

Disease

Lupus erythematosus;FunDO

Disease

cirrhosis, alcoholic;GAD

Disease

IMMUNE;GAD

Disease

Prostatic Neoplasms;GAD

Disease

Albuminuria;GAD

Disease

radiotherapy response;GAD

Disease

Alzheimer's disease;GAD

Disease

breast cancer;GAD

Disease

carotid atherosclerosis;GAD

Disease

Asthma;FunDO

Disease

diabetes, type 2;GAD

Disease

Cancer;FunDO

Disease

Microvascular complications of diabetes, susceptibility to, 6;OMIM

Disease

bladder cancer;GAD

Disease

HIV infection;FunDO

Disease

Glaucoma;FunDO

Disease

Skin cancer;FunDO

Disease

AGING;GAD

Disease

hypertension;GAD

Disease

prostate cancer;GAD

Disease

lung cancer;GAD

Disease

nephropathy in other diseases;GAD

Disease

Parkinson's disease;GAD

Disease

schizophrenia tardive dyskinesia;GAD

Disease

diabetes, neurological manifestations;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

cardiomyopathy;GAD

Disease

Systemic infection;FunDO

Disease

METABOLIC;GAD

Disease

Schizophrenia;FunDO

Disease

Cirrhosis;FunDO

Disease

Alzheimer's disease;FunDO

Disease

psoriatic arthritis;GAD

Disease

colorectal cancer;GAD

Disease

Pre-Eclampsia;FunDO

Disease

diabetic polyneuropathy;GAD

Disease

PSYCH;GAD

Disease

diabetes, type 1;GAD

Disease

Lung Neoplasms;GAD

Disease

liver injury, drug-induced;GAD

Disease

Psychotic disorder;FunDO

Disease

CARDIOVASCULAR;GAD

Disease

Kuhnt-Junius degeneration;FunDO

Disease

Drug-Induced dyskinesia;FunDO

Disease

Pancreas disease;FunDO

Disease

steatohepatitis, non-alcoholic;GAD

Disease

Chronic obstructive airway disease;FunDO

Disease

NEUROLOGICAL;GAD

Disease

tardive dyskinesia;GAD

Disease

Behcet's Disease;GAD

Disease

nephropathy, diabetic;GAD

Disease

Behcet syndrome;FunDO

Disease

cholesterol;GAD

Disease

RENAL;GAD

Disease

leukemia;GAD

Disease

liver cancer;GAD

Disease

CANCER;GAD

Disease

schizophrenia;GAD

Disease

Barrett's esophagus;FunDO

Disease

Diabetes Mellitus;GAD

Disease

aging and longevity;GAD

Disease

diabetic nephropathy diabetic neuropathy;GAD

Disease

Arthritis;FunDO

Disease

stomach cancer;GAD

Disease

Ankylosing spondylitis;FunDO

External Links

Links to Entrez Gene

6648

Links to all GeneRIF Items

6648

Links to iHOP

6648

Sequence Information

Nucleotide Sequence

>6648 : length: 669
atgttgagccgggcagtgtgcggcaccagcaggcagctggctccggttttggggtatctg
ggctccaggcagaagcacagcctccccgacctgccctacgactacggcgccctggaacct
cacatcaacgcgcagatcatgcagctgcaccacagcaagcaccacgcggcctacgtgaac
aacctgaacgtcaccgaggagaagtaccaggaggcgttggccaagggagatgttacagcc
cagatagctcttcagcctgcactgaagttcaatggtggtggtcatatcaatcatagcatt
ttctggacaaacctcagccctaacggtggtggagaacccaaaggggagttgctggaagcc
atcaaacgtgactttggttcctttgacaagtttaaggagaagctgacggctgcatctgtt
ggtgtccaaggctcaggttggggttggcttggtttcaataaggaacggggacacttacaa
attgctgcttgtccaaatcaggatccactgcaaggaacaacaggccttattccactgctg
gggattgatgtgtgggagcacgcttactaccttcagtataaaaatgtcaggcctgattat
ctaaaagctatttggaatgtaatcaactgggagaatgtaactgaaagatacatggcttgc
aaaaagtaa

Protein Sequence

>6648 : length: 222
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK



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