| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 846 |
Name | CASR |
Synonym | CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|NSHPT|PCAR1;calcium-sensing receptor;CASR;calcium-sensing receptor |
Definition | extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1|parathyroid cell calcium-sensing receptor |
Position | 3q13 |
Gene Type | protein-coding |
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PAH Type |
Description |
PH | "The extracellular calcium-induced increase in cytosolic Ca(2+) due to upregulated CaSR, contributes to the augmented Ca(2+) influx and excessive pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension." |
PH | "The extracellular calcium-induced increase in cytosolic Ca(2+) due to upregulated CaSR, contributes to the augmented Ca(2+) influx and excessive pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension." |
PH | "The extracellular calcium-induced increase in cytosolic Ca(2+) due to upregulated CaSR, contributes to the augmented Ca(2+) influx and excessive pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension." |
| More detail of all Human literatures about CASR | |
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Pathways and Diseases |
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Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Class C/3 (Metabotropic glutamate/pheromone receptors);PID Reactome;500431 |
Disease | Hypocalcemia, autosomal dominant, with Bartter syndrome;OMIM |
Disease | Hypocalciuric hypercalcemia, type I;OMIM |
Disease | Hyperparathyroidism, neonatal;OMIM |
Disease | primary hyperparathyroidism;GAD |
Disease | total serum calcium;GAD |
Disease | hyperparathyroidism;GAD |
Disease | electrolyte levels;GAD |
Disease | Pancreatitis;FunDO |
Disease | calcium cardiac death heart disease, ischemic myocardial infarct phosphate;GAD |
Disease | Multiple myeloma;FunDO |
Disease | Familial hypocalciuric hypercalcemia;GAD |
Disease | Epilepsy, idiopathic generalized, susceptibility to, 8;OMIM |
Disease | METABOLIC;GAD |
Disease | Hyperparathyroidism;FunDO |
Disease | colorectal cancer;GAD |
Disease | Autoimmune disease;FunDO |
Disease | bone density;GAD |
Disease | Serum calcium;NHGRI |
Disease | Serum phosphorus concentrations;NHGRI |
Disease | CARDIOVASCULAR;GAD |
Disease | Vitamin D deficiency;FunDO |
Disease | Hypocalcemia, autosomal dominant;OMIM |
Disease | CANCER;GAD |
Disease | Kidney failure;FunDO |
Disease | albumin bone density calcium fractures, vertebral hyperparathyroidism kidney stone disease;GAD |
Disease | Colon cancer;FunDO |
Disease | calcium;GAD |
Disease | Primary hyperparathyroidism;FunDO |
Disease | hypercalciuria;GAD |
Disease | hyperparathyroidism, primary;GAD |
Disease | Epilepsy;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 846 |
Links to all GeneRIF Items | 846 |
Links to iHOP | 846 |
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Sequence Information |
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Nucleotide Sequence |
>846 : length: 3237 atggcattttatagctgctgctgggtcctcttggcactcacctggcacacctctgcctac gggccagaccagcgagcccaaaagaagggggacattatccttggggggctctttcctatt cattttggagtagcagctaaagatcaagatctcaaatcaaggccggagtctgtggaatgt atcaggtataatttccgtgggtttcgctggttacaggctatgatatttgccatagaggag ataaacagcagcccagcccttcttcccaacttgacgctgggatacaggatatttgacact tgcaacaccgtttctaaggccttggaagccaccctgagttttgttgctcaaaacaaaatt gattctttgaaccttgatgagttctgcaactgctcagagcacattccctctacgattgct gtggtgggagcaactggctcaggcgtctccacggcagtggcaaatctgctggggctcttc tacattccccaggtcagttatgcctcctccagcagactcctcagcaacaagaatcaattc aagtctttcctccgaaccatccccaatgatgagcaccaggccactgccatggcagacatc atcgagtatttccgctggaactgggtgggcacaattgcagctgatgacgactatgggcgg ccggggattgagaaattccgagaggaagctgaggaaagggatatctgcatcgacttcagt gaactcatctcccagtactctgatgaggaagagatccagcatgtggtagaggtgattcaa aattccacggccaaagtcatcgtggttttctccagtggcccagatcttgagcccctcatc aaggagattgtccggcgcaatatcacgggcaagatctggctggccagcgaggcctgggcc agctcctccctgatcgccatgcctcagtacttccacgtggttggcggcaccattggattc gctctgaaggctgggcagatcccaggcttccgggaattcctgaagaaggtccatcccagg aagtctgtccacaatggttttgccaaggagttttgggaagaaacatttaactgccacctc caagaaggtgcaaaaggacctttacctgtggacacctttctgagaggtcacgaagaaagt ggcgacaggtttagcaacagctcgacagccttccgacccctctgtacaggggatgagaac atcagcagtgtcgagaccccttacatagattacacgcatttacggatatcctacaatgtg tacttagcagtctactccattgcccacgccttgcaagatatatatacctgcttacctggg agagggctcttcaccaatggctcctgtgcagacatcaagaaagttgaggcgtggcaggtc ctgaagcacctacggcatctaaactttacaaacaatatgggggagcaggtgacctttgat gagtgtggtgacctggtggggaactattccatcatcaactggcacctctccccagaggat ggctccatcgtgtttaaggaagtcgggtattacaacgtctatgccaagaagggagaaaga ctcttcatcaacgaggagaaaatcctgtggagtgggttctccagggaggtgcccttctcc aactgcagccgagactgcctggcagggaccaggaaagggatcattgagggggagcccacc tgctgctttgagtgtgtggagtgtcctgatggggagtatagtgatgagacagatgccagt gcctgtaacaagtgcccagatgacttctggtccaatgagaaccacacctcctgcattgcc aaggagatcgagtttctgtcgtggacggagccctttgggatcgcactcaccctctttgcc gtgctgggcattttcctgacagcctttgtgctgggtgtgtttatcaagttccgcaacaca cccattgtcaaggccaccaaccgagagctctcctacctcctcctcttctccctgctctgc tgcttctccagctccctgttcttcatcggggagccccaggactggacgtgccgcctgcgc cagccggcctttggcatcagcttcgtgctctgcatctcatgcatcctggtgaaaaccaac cgtgtcctcctggtgtttgaggccaagatccccaccagcttccaccgcaagtggtggggg ctcaacctgcagttcctgctggttttcctctgcaccttcatgcagattgtcatctgtgtg atctggctctacaccgcgcccccctcaagctaccgcaaccaggagctggaggatgagatc atcttcatcacgtgccacgagggctccctcatggccctgggcttcctgatcggctacacc tgcctgctggctgccatctgcttcttctttgccttcaagtcccggaagctgccggagaac ttcaatgaagccaagttcatcaccttcagcatgctcatcttcttcatcgtctggatctcc ttcattccagcctatgccagcacctatggcaagtttgtctctgccgtagaggtgattgcc atcctggcagccagctttggcttgctggcgtgcatcttcttcaacaagatctacatcatt ctcttcaagccatcccgcaacaccatcgaggaggtgcgttgcagcaccgcagctcacgct ttcaaggtggctgcccgggccacgctgcgccgcagcaacgtctcccgcaagcggtccagc agccttggaggctccacgggatccaccccctcctcctccatcagcagcaagagcaacagc gaagacccattcccacagcccgagaggcagaagcagcagcagccgctggccctaacccag caagagcagcagcagcagcccctgaccctcccacagcagcaacgatctcagcagcagccc agatgcaagcagaaggtcatctttggcagcggcacggtcaccttctcactgagctttgat gagcctcagaagaacgccatggcccacaggaattctacgcaccagaactccctggaggcc cagaaaagcagcgatacgctgacccgacaccagccattactcccgctgcagtgcggggaa acggacttagatctgaccgtccaggaaacaggtctgcaaggacctgtgggtggagaccag cggccagaggtggaggaccctgaagagttgtccccagcacttgtagtgtccagttcacag agctttgtcatcagtggtggaggcagcactgttacagaaaacgtagtgaattcataa |
Protein Sequence |
>846 : length: 1078 MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGE TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS |