Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1490

Name

CTGF

Synonymous

CCN2|HCS24|IGFBP8|NOV2;connective tissue growth factor;CTGF;connective tissue growth factor

Definition

CCN family member 2|IBP-8|IGF-binding protein 8|IGFBP-8|hypertrophic chondrocyte-specific protein 24|insulin-like growth factor-binding protein 8

Position

6q23.1

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

There is no record for CTGF

Transcription Factors   [Top]

Regulation From TransFac database

CTGF(h) --> MEK(h){pS217}{pS221} (increase of phosphorylation)
CTGF(h) --> JNK(h){pT183}{pY185} (increase of phosphorylation)
CTGF(h) --> RSK(h){pS} (increase of phosphorylation)
CTGF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation)
CTGF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation)
CTGF(h) --> MKK4(h){pT261} (increase of phosphorylation)
CTGF(h) --> ATF-2(h){pT} (increase of phosphorylation)
CTGF(h) --> CaMKII-alpha(h){pT286} (increase of phosphorylation)
CTGF(h) --> AKT-1(h){pT308}{pS473} (increase of phosphorylation)
trkA(h) + CTGF(h) <==> trkA(h):CTGF(h) (binding)
p75NTR(h) + CTGF(h) <==> p75NTR(h):CTGF(h) (binding)
CTGF(h) --> CTGF(h) (expression).
CTGF(h) --> CTGF-isoform1(h) (expression).
CTGF(h) --> CTGF-isoform2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

28N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
225N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr6

Promoter: 132313711 - 132315711Agilent_014791

chr6

Promoter: 132313711 - 132315711GoldenGate_Methylation_Cancer_Panel_I

chr6

Promoter: 132313711 - 132315711GSE27584

chr6

Promoter: 132313711 - 132315711Agilent_014791_44K

chr6

Promoter: 132313711 - 132315711PMID:15911243


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