Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	1849
Name	DUSP7
Synonymous	MKPX\|PYST2;dual specificity phosphatase 7;DUSP7;dual specificity phosphatase 7
Definition	dual specificity protein phosphatase 7\|dual specificity protein phosphatase PYST2\|dual-specificity phosphatase-7
Position	3p21
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Link to UCSC genome	Matched SNP location	dbSNP ID	Regulatory information
ENCODE RegulomeDB [Top]
chr3:52082935-52090566	chr3:52088651-52088651	rs4687607	Single_Nucleotides\|eQTL\|DUSP7, Motifs\|Footprinting\|LRF, Motifs\|Footprinting\|LRF, Motifs\|Footprinting\|LRF, Motifs\|PWM\|LRF, Chromatin_Structure\|FAIRE\|Helas3, Chromatin_Structure\|FAIRE\|Htr8, Chromatin_Structure\|DNase-seq\|Gm12892, Chromatin_Structure\|DNase-seq\|Lncap, Chromatin_Structure\|DNase-seq\|Gm12878, Chromatin_Structure\|DNase-seq\|Nb4, Chromatin_Structure\|DNase-seq\|8988t, Chromatin_Structure\|DNase-seq\|Gm12891, Chromatin_Structure\|FAIRE\|Gm12892, Chromatin_Structure\|DNase-seq\|Gm19239, Chromatin_Structure\|DNase-seq\|Stellate, Chromatin_Structure\|DNase-seq\|Osteobl, Chromatin_Structure\|DNase-seq\|Gm19238

Regulation From TransFac database
Transcription Factors [Top]
MKP-X(h) + ERK2(m) <==> MKP-X(h):ERK2(m) (binding)
DUSP7(h) --> MKP-X(h) (expression).
ERK2(m){p} --MKP-X(h)--> ERK2(m) + p (dephosphorylation)
p38alpha(m){p} --MKP-X(h)--> p38alpha(m) + p (dephosphorylation)

Post Transcriptional Modification [Top]
	There is no record for DUSP7

Chromosome	Location	Source
Methylation Profile [Top]
chr3	Promoter: 52064829 - 52066829	Agilent_014791
chr3	Promoter: 52064829 - 52066829	GSE27584
chr3	Promoter: 52064829 - 52066829	Agilent_014791

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