| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 51144 |
Name | HSD17B12 |
Synonymous | KAR|SDR12C1;hydroxysteroid (17-beta) dehydrogenase 12;HSD17B12;hydroxysteroid (17-beta) dehydrogenase 12 |
Definition | 17-beta-HSD 12|17-beta-hydroxysteroid dehydrogenase 12|17beta-HSD type 12|3-ketoacyl-CoA reductase|estradiol 17-beta-dehydrogenase 12|short chain dehydrogenase/reductase family 12C, member 1|steroid dehydrogenase homolog |
Position | 11p11.2 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr11:43577986-43878167 | chr11:43635734-43635734 | rs10768966 | Single_Nucleotides|eQTL|HSD17B12, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|SETDB1 | chr11:43577986-43878167 | chr11:43653833-43653833 | rs2862996 | Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Sknmc, Chromatin_Structure|DNase-seq|8988t, Protein_Binding|ChIP-seq|FOS, Protein_Binding|ChIP-seq|JUN | chr11:43577986-43878167 | chr11:43660255-43660255 | rs9783304 | Single_Nucleotides|eQTL|HSD17B12, Protein_Binding|ChIP-seq|RFX3 | chr11:43577986-43878167 | chr11:43671734-43671734 | rs11037537 | Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Caco2, Protein_Binding|ChIP-seq|AR, Protein_Binding|ChIP-seq|GATA6 | chr11:43577986-43878167 | chr11:43696316-43696316 | rs6485443 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Jurkat | chr11:43577986-43878167 | chr11:43721672-43721672 | rs12277307 | Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|K562, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1 | chr11:43577986-43878167 | chr11:43747912-43747912 | rs12800235 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|H7es, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA6 | chr11:43577986-43878167 | chr11:43754372-43754372 | rs10768975 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Rptec | chr11:43577986-43878167 | chr11:43760607-43760607 | rs4755735 | Single_Nucleotides|eQTL|HSD17B12, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|PWM|GATA-1, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Hct116, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Hpf, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Hvmf, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hconf, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Ag09309, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Ag04450, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hpdlf, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Hrpe, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Ag09319, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Bj, Chromatin_Structure|DNase-seq|Be2c, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Sknmc, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|FAIRE|Astrocy, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|TFAP2A, Protein_Binding|ChIP-seq|TFAP2C, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|SPI1, Protein_Binding|ChIP-seq|SIX5, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|SPI1, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|GATA3, Protein_Binding|ChIP-seq|SMARCA4 | chr11:43577986-43878167 | chr11:43768254-43768254 | rs10742688 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hl60, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|MAX, Protein_Binding|ChIP-seq|TAL1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|MAX, Protein_Binding|ChIP-seq|JUNB, Protein_Binding|ChIP-seq|JUND | chr11:43577986-43878167 | chr11:43769295-43769295 | rs7115970 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|K562, Protein_Binding|ChIP-seq|SMARCA4, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|SMARCA4, Protein_Binding|ChIP-seq|SMARCB1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|GATA6, Protein_Binding|ChIP-seq|MYC, Protein_Binding|ChIP-seq|CCNT2, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|POLR2A | chr11:43577986-43878167 | chr11:43773813-43773813 | rs10768976 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Motifs|PWM|ISGF-3, Protein_Binding|ChIP-seq|RFX3 | chr11:43577986-43878167 | chr11:43775734-43775734 | rs4643069 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|T47d | chr11:43577986-43878167 | chr11:43825481-43825481 | rs6485464 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|FAIRE|Astrocy, Chromatin_Structure|DNase-seq|Nhdfneo | chr11:43577986-43878167 | chr11:43839935-43839935 | rs10768983 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Ag09309, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|FAIRE|Nhek, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Hipe | chr11:43577986-43878167 | chr11:43846850-43846850 | rs7131110 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Ag04450, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|FAIRE|H1hesc, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Ag04449, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|SMC3, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|CTCF | chr11:43577986-43878167 | chr11:43868651-43868651 | rs939015 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmveclbl | chr11:43577986-43878167 | chr11:43873539-43873539 | rs1518820 | Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|FAIRE|Gm19239, Chromatin_Structure|FAIRE|Htr8, Chromatin_Structure|DNase-seq|Gliobla |
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Transcription Factors [Top] |
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Regulation From TransFac database |
HSD17B12(h) --> estradiol 17-beta-dehydrogenase 12(h) (expression). | HSD17B12(h) --> estradiol 17-beta-dehydrogenase 12(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for HSD17B12 | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr11 |
Promoter: 43657381 - 43659381 | Agilent_014791 |
chr11 |
Promoter: 43657381 - 43659381 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 43657381 - 43659381 | GSE27584 |
chr11 |
Promoter: 43657381 - 43659381 | Agilent_014791_44K |