| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 7046 |
Name | TGFBR1 |
Synonymous | AAT5|ACVRLK4|ALK-5|ALK5|LDS1A|LDS2A|MSSE|SKR4|TGFR-1;transforming growth factor, beta receptor 1;TGFBR1;transforming growth factor, beta receptor 1 |
Definition | TGF-beta receptor type I|TGF-beta receptor type-1|TGF-beta type I receptor|activin A receptor type II-like kinase, 53kD|activin A receptor type II-like kinase, 53kDa|activin A receptor type II-like protein kinase of 53kD|activin receptor-like kinase 5|ser |
Position | 9q22 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for TGFBR1 | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
TGFbeta1(h) + TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) (binding) | TGFbeta1(h) + TGFbetaR-II(pg) + TGFbetaR-I(h) <==> TGFbeta1(h):TGFbetaR-II(pg):TGFbetaR-I(h) (binding) | TGFbetaR-I(h) + FKBP12(h) <==> TGFbetaR-I(h):FKBP12(h) (binding) | TGFbetaR-I(h) + TRAP-1(h) <==> TGFbetaR-I(h):TRAP-1(h) (binding) | TGFbetaR-II(h) + TGFbetaR-I(h) + Smad2-L(h) <==> TGFbetaR-II(h):TGFbetaR-I(h):Smad2-L(h) (binding) | TGFbeta1(h):TGFbetaR-III(h):TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) + TGFbetaR-III(h) (binding) | TGFbeta1(pg) + TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(pg):TGFbetaR-II(h):TGFbetaR-I(h) (binding) | TGFbetaR-I(h) + n ubiquitin(h) --Smurf-1(h)--> TGFbetaR-I(h){ub(n)} (ubiquitination) | TGFbeta1(v.s.) + TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(v.s.):TGFbetaR-II(h):TGFbetaR-I(h) (binding) | TGFbetaR-II(h) + TGFbetaR-I(h) + ATP --> TGFbetaR-II(h){p} + TGFbetaR-I(h){p} + ADP (phosphorylation) | TGFbeta1(v.s.) + TGFbetaR-II(h) + TGFbetaR-I(h) + Dnlc2a(h) <==> TGFbeta1(v.s.):TGFbetaR-II(h):TGFbetaR-I(h):Dnlc2a(h) (binding) | TGFbetaR-I(h) + endoglin(h) <==> TGFbetaR-I(h):endoglin(h) (binding) | TGFbetaR-I(h) + ATP --TGFbetaR-II(h):endoglin(h)--> TGFbetaR-I(h){p} + ADP (phosphorylation) | (TGFbeta1(h))2 + TGFbetaR-II(h) + TGFbetaR-I(h) <==> (TGFbeta1(h))2:TGFbetaR-II(h):TGFbetaR-I(h) (binding) | (TGFbeta1(h))2 + 2 TGFbetaR-I(h) <==> (TGFbeta1(h))2:(TGFbetaR-I(h))2 (binding) | TGFbetaR-I(h) + ATP --TGFbetaR-II(h){pS213}--> TGFbetaR-I(h){p} + ADP (phosphorylation) | TGFbetaR-I(h) + Dab2(h) <==> TGFbetaR-I(h):Dab2(h) (binding) | TGFBR1(h) --> TGFbetaR-I(h) (expression). | Smad2-L(h) + NTP --TGFbetaR-I(h)--> Smad2-L(h){p} + NDP (phosphorylation) | Smad2-L(h) + smad4(h) --TGFbetaR-I(h)--> Smad2-L(h):smad4(h) (binding) | Smad3(h) + ATP --TGFbetaR-I(h)--> Smad3(h){p} + ADP (phosphorylation) | Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | Smad3(h) + smad4(h) --TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding) | Smad2-L(h) + ATP --TGFbetaR-I(h)--> Smad2-L(h){p} + ADP (phosphorylation) | endoglin(h) + ATP --TGFbetaR-I(h)--> endoglin(h){p} + ADP (phosphorylation) | TGFbetaR-I(h) + Dab2(mo) <==> TGFbetaR-I(h):Dab2(mo) (binding) | TGFBR1(h) --> TGFbetaR-I(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
45 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 185 | Phosphothreonine. | Swiss-Prot 53.0 | 186 | Phosphothreonine. | Swiss-Prot 53.0 | 187 | Phosphoserine. | Swiss-Prot 53.0 | 189 | Phosphoserine. | Swiss-Prot 53.0 | 191 | Phosphoserine. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr9 |
Promoter: 100905733 - 100907733 | Agilent_014791 |
chr9 |
Promoter: 100905733 - 100907733 | GSE27584 |
chr9 |
Promoter: 100905733 - 100907733 | Agilent_014791_44K |
chr9 |
Promoter: 100905733 - 100907733 | PMID:11408925 |