Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7057

Name

THBS1

Synonymous

THBS|THBS-1|TSP|TSP-1|TSP1;thrombospondin 1;THBS1;thrombospondin 1

Definition

thrombospondin-1|thrombospondin-1p180

Position

15q15

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

There is no record for THBS1

Transcription Factors   [Top]

Regulation From TransFac database

LAP(h) + TSP-1(h) <==> LAP(h):TSP-1(h) (binding)
TSP-1(h) + GP4(h) <==> TSP-1(h):GP4(h) (binding)
TSP-1(h) + mmp2(h) <==> TSP-1(h):mmp2(h) (binding)
TSP-1(h) + gelatinase B(h) <==> TSP-1(h):gelatinase B(h) (binding)
TSP-1(h) + mmp2(m) <==> TSP-1(h):mmp2(m) (binding)
Antithrombin-III(m.s.) + thrombin(m.s.) + TSP-1(h) <==> Antithrombin-III(m.s.):thrombin(m.s.):TSP-1(h) (binding)
TSP-1(h) + PDI(h) <==> TSP-1(h):PDI(h) (binding)
TSP-1(h) --> p38(h){p} (increase of phosphorylation)
THBS1(h) --> TSP-1(h) (expression).
IGFBP-5(h) + TSP-1(h) <==> IGFBP-5(h):TSP-1(h) (binding)
TSP-1(h) + IGFBP-3(h) <==> TSP-1(h):IGFBP-3(h) (binding)
TSP-1(h) + IGFBP-4(h) <==> TSP-1(h):IGFBP-4(h) (binding)
THBS1(h) --> TSP-1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

248N-linked (GlcNAc...).Swiss-Prot 53.0
360N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
708N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1067N-linked (GlcNAc...).Swiss-Prot 53.0
P0799SP07996OGlycBase6.0
P0799TP07996OGlycBase6.0
P0799TP07996OGlycBase6.0
P0799NP07996OGlycBase6.0
P0799WP07996OGlycBase6.0
P0799WP07996OGlycBase6.0
P0799WP07996OGlycBase6.0
P0799WP07996OGlycBase6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr15

Promoter: 37659072 - 37661072Agilent_014791

chr15

Promoter: 37659072 - 37661072GoldenGate_Methylation_Cancer_Panel_I

chr15

Promoter: 37659072 - 37661072GSE27584

chr15

Promoter: 37659072 - 37661072Agilent_014791_44K

chr15

Promoter: 37659072 - 37661072Agilent_014791

chr15

Promoter: 37659072 - 37661072PMID:14742272

chr15

Promoter: 37659072 - 37661072PMID:14507661

chr15

Promoter: 37659072 - 37661072PMID:11146446

chr15

Promoter: 37659072 - 37661072PMID:16075282

chr15

Promoter: 37659072 - 37661072PMID:17374440

chr15

Promoter: 37659072 - 37661072PMID:11306456

chr15

Promoter: 37659072 - 37661072PMID:12695555

chr15

Promoter: 37659072 - 37661072PMID:12746473

chr15

Promoter: 37659072 - 37661072PMID:12759541

chr15

Promoter: 37659072 - 37661072PMID:12579314

chr15

Promoter: 37659072 - 37661072PMID:16983315

chr15

Promoter: 37659072 - 37661072PMID:14654541

chr15

Promoter: 37659072 - 37661072PMID:15365725

chr15

Promoter: 37659072 - 37661072PMID:15892004

chr15

Promoter: 37659072 - 37661072PMID:12826052

chr15

Promoter: 37659072 - 37661072PMID:16391867

chr15

Promoter: 37659072 - 37661072PMID:15122305

chr15

Promoter: 37659072 - 37661072PMID:15389252

chr15

Promoter: 37659072 - 37661072PMID:16336454

chr15

Promoter: 37659072 - 37661072PMID:15623630

chr15

Promoter: 37659072 - 37661072PMID:15788647

chr15

Promoter: 37659072 - 37661072PMID:14559817

chr15

Promoter: 37659072 - 37661072PMID:12660028

chr15

Promoter: 37659072 - 37661072PMID:16858686

chr15

Promoter: 37659072 - 37661072PMID:15172987

chr15

Promoter: 37659072 - 37661072PMID:17139617

chr15

Promoter: 37659072 - 37661072PMID:10766168

chr15

Promoter: 37659072 - 37661072PMID:12213730

chr15

Promoter: 37659072 - 37661072PMID:12114423

chr15

Promoter: 37659072 - 37661072PMID:12632081


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