Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase

Found 39 literature records

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Entrez IDDescription
400410"Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer."
6422These results indicate that the human secreted frizzled-related protein (hsFRP) gene probably functions as a tumor suppressor in normal cervical epithelium and down-regulation of hsFRP contributes to development of cervical cancer.
11186Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers.
11186The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix.
324"The tumor suppressor gene, APC, is an independent prognostic parameter with poor outcome in breast cancer patients."
11186"The tumor suppressor gene, RASSF1A, is an independent prognostic parameter with poor outcome in breast cancer patients."
5178"Loss of PEG3 expression may be a frequent event in gynecologic cancers. Given the known role of PEG3 in p53-mediated apoptosis, it is possible that PEG3 functions as a tumor suppressor."
2272Findings suggest that the tumor suppressor gene FHIT may represent a molecular target in cigarette smoking-associated cervical carcinogenesis.
25833"POU2F3 in cervical cancer cells may be CC-related tumor suppressor genes, which are disrupted by both epigenetic and genetic mechanisms."
10904might be a potential tumor suppressor gene in cervical carcinoma.
1915potential tumor suppressor activity of CCS-3 may be mediated by its interaction with PLZF.
23705Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis.
5519Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer.
7157Data demonstrate a novel link between p53 and Notch1 in keratinocyte differentiation upon genotoxic stress and suggest a novel tumor suppressor mechanism of p53 in the development of HPV-induced tumors.
2272Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer.
5925the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB tumor suppressor in HPV16 E7-expressing cells.
9353Deletions in chromosome 4 differentially associated with the development of cervical cancer: evidence of slit2 as a candidate tumor suppressor gene.
5925"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
7157"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
26018a role of LRIG1 in tumor suppression in the uterine cervix
1029"P16INK4A is overexpressed in HR-HPV-infected cervical cancer, but its tumor suppressor action might be inhibited."
1474Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer.
6794"LKB1 is thus a major cervical tumor suppressor, demonstrating that acquired genetic alterations drive progression of HPV-induced dysplasias to invasive, lethal cancers"
1026Results show that that p21(Cip1) functions as a tumor suppressor in cervical carcinogenesis and that p21(Cip1) inactivation by HPV-16 E7 partially contributes to the contribution of E7 to cervical carcinogenesis.
9113Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice.
27250"miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation, and up-regulated the expression of the tumor suppressor gene PDCD4."
6794LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas and cervical cancers.
7538Findings demonstrate the ability of TTP to act as a tumor suppressor by inhibiting the E6-AP pathway and indicate TTP loss to be a critical event during HPV-mediated cervical cancer carcinogenesis.
7799DNA methylation of the RIZ1 tumor suppressor gene plays an important role in the tumorigenesis of cervical cancer.
5268Testisin may promote carcinogenesis by inhibiting tumor suppressor activity of maspin.
5071"Allelic loss of 6q25-27, the PARKIN tumor suppressor gene locus, in cervical carcinoma."
26468hLHX6.1 could be a new tumor suppressor gene in the cervix.
9365our results suggest that klotho is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in colorectal cancer
51406NOL7 is the legitimate tumor suppressor gene located on 6p23.
494336Results identify a crucial tumor suppressive role of miR-424 in the progression of cervical cancer at least partly via upreglating the expression of Chk1.
442912"A new cell cycle regulatory pathway was identified ain which the miR-302-367 cluster directly down-regulated both cyclin D1 and AKT1 and indirectly up-regulated p27Kip1 and p21Cip1, leading to the suppression of cervical cancer cell proliferation."
6656"Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in cervical cancer."
199AIF-1 functions as a tumor suppressor possibly by regulating beta-catenin in gastric cancer. the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.
324Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein.

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