Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase

Found 20 literature records

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Entrez IDDescription
1031"p18INK4c may function as a tumor suppressor in Hodgkin lymphoma, and inactivation may contribute to cell cycle deregulation and defective terminal differentiation of the Reed-Sternberg cells."
8795TRAIL-R1 and TRAIL-R2 act as dosage-dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL-induced apoptosis in B-cell lymphoma
8797TRAIL-R1 and TRAIL-R2 act as dosage-dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL-induced apoptosis in B-cell lymphoma
8651Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation
5796"EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor"
8651mediastinal B-cell lymphoma and hodgkin lymphoma cells share overlapping features and defective tumor suppressor gene SOCS-1 triggers an oncogenic pathway operative in both Hodgkin and non-Hodgkin lymphomas.
10395"Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas."
4978"OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies."
23136"Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma."
23705"Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma."
7128TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
7128TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas.
9314KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma.
10395DLC-1 may play an important role in lymphoma by acting as a bona fide new tumor suppressor gene.
22882"Expression profiling of L-1236 cells following siRNA-mediated knockdown of ZHX2 showed inhibition of genes regulating differentiation and apoptosis, suggesting tumor suppressor activity of ZHX2."
22882results demonstrate multiple mechanisms decreasing expression of tumor suppressor gene ZHX2 in Hodgkin lymphoma cell lines
639PRDM1 is a tumor suppressor gene in natural killer cell malignancies.
6688Data suggest that PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma (cHL) and that induction of PU.1 with demethylation agents and/or histone deacetylase inhibitors is a possible therapeutic option for patients with cHL.
5770Findings implicate PTPN1 as a tumor suppressor gene in Primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma and suggest that loss of PTPN1 phosphatase activity may promote the development of these cancers.
407020Our data suggest that miR-28 acts as a tumor suppressor in B-cell lymphoma and that its repression by MYC contributes to B-cell lymphomagenesis.

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