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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3394 |
Name | IRF8 |
Synonym | H-ICSBP|ICSBP|ICSBP1|IRF-8;interferon regulatory factor 8;IRF8;interferon regulatory factor 8 |
Definition | interferon consensus sequence binding protein 1 |
Position | 16q24.1 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 2 PubMed records as below. |
|
Evidence Status |
Description |
potential | "IRF8 was identified as a functional tumor suppressor, which is frequently silenced by epigenetic mechanism in multiple carcinomas". |
reviewed | Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia. |
| More detail of all 2 literatures about IRF8 | |
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Pathways and Diseases |
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Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Disease | Carcinoma;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | multiple sclerosis;GAD |
Disease | IMMUNE;GAD |
Disease | Infection;FunDO |
Disease | Chronic lymphocytic leukemia;NHGRI |
Disease | Chronic lymphocytic leukemia;GAD |
Disease | Lymphoma;FunDO |
Disease | Leukemia;FunDO |
Disease | CANCER;GAD |
Disease | Multiple sclerosis;NHGRI |
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External Links |
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Links to Entrez Gene | 3394 |
Links to all GeneRIF Items | 3394 |
Links to iHOP | 3394 |
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Sequence Information |
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Nucleotide Sequence |
>3394 : length: 1281 atgtgtgaccggaatggtggtcggcggcttcgacagtggctgatcgagcagattgacagt agcatgtatccaggactgatttgggagaatgaggagaagagcatgttccggatcccttgg aaacacgctggcaagcaagattataatcaggaagtggatgcctccatttttaaggcctgg gcagtttttaaagggaagtttaaagaaggggacaaagctgaaccagccacttggaagacg aggttacgctgtgctttgaataagagcccagattttgaggaagtgacggaccggtcccaa ctggacatttccgagccatacaaagtttaccgaattgttcctgaggaagagcaaaaatgc aaactaggcgtggcaactgctggctgcgtgaatgaagttacagagatggagtgcggtcgc tctgaaatcgacgagctgatcaaggagccttctgtggacgattacatggggatgatcaaa aggagcccttccccgccggaggcctgtcggagtcagctccttccagactggtgggcgcag cagcccagcacaggcgtgccgctggtgacggggtacaccacctacgacgcgcaccattca gcattctcccagatggtgatcagcttctactatgggggcaagctggtgggccaggccacc accacctgccccgagggctgccgcctgtccctgagccagcctgggctgcccggcaccaag ctgtatgggcccgagggcctggagctggtgcgcttcccgccggccgacgccatccccagc gagcgacagaggcaggtgacgcggaagctgttcgggcacctggagcgcggggtgctgctg cacagcagccggcagggcgtgttcgtcaagcggctgtgccagggccgcgtgttctgcagc ggcaacgccgtggtgtgcaaaggcaggcccaacaagctggagcgtgatgaggtggtccag gtcttcgacaccagccagttcttccgagagctgcagcagttctataacagccagggccgg cttcctgacggcagggtggtgctgtgctttggggaagagtttccggatatggcccccttg cgctccaaactcattctcgtgcagattgagcagctgtatgtccggcaactggcagaagag gctgggaagagctgtggagccggctctgtgatgcaggcccccgaggagccgccgccagac caggtcttccggatgtttccagatatttgtgcctcacaccagagatcatttttcagagaa aaccaacagatcaccgtctaa |
Protein Sequence |
>3394 : length: 426 MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAW AVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKC KLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWAQ QPSTGVPLVTGYTTYDAHHSAFSQMVISFYYGGKLVGQATTTCPEGCRLSLSQPGLPGTK LYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLHSSRQGVFVKRLCQGRVFCS GNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPL RSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQAPEEPPPDQVFRMFPDICASHQRSFFRE NQQITV |