Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5333

Name

PLCD1

Synonym

NDNC3|PLC-III;phospholipase C, delta 1;PLCD1;phospholipase C, delta 1

Definition

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1|PLC-delta-1|phosphoinositide phospholipase C-delta-1|phospholipase C-III

Position

3p22-p21.3

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

potential

"PLCD1 is silenced by promoter methylation in breast cancer. Silencing of PLCD1 is reversed by demethylation which leads to the disruption of cell cycle at G2/M phase in breast cancer, indicating that PLCD1 functions as a tumor suppressor in this tumor."

potential

PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis.

reviewed

Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma.
More detail of all 3 literatures about PLCD1

Pathways and Diseases

Pathway

D-myo-inositol (1,4,5)-trisphosphate biosynthesis;BioCyc;PWY-6351

Pathway

D-myo-inositol-5-phosphate metabolism;BioCyc;PWY-6367

Pathway

Oxytocin receptor mediated signaling pathway;PANTHER;P04391

Pathway

Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070

Pathway

Histamine H1 receptor mediated signaling pathway;PANTHER;P04385

Pathway

phospholipases;BioCyc;LIPASYN-PWY

Pathway

Inositol phosphate metabolism;KEGG PATHWAY;hsa00562

Pathway

Metabolic pathways;KEGG PATHWAY;hsa01100

Pathway

5HT2 type receptor mediated signaling pathway;PANTHER;P04374

Pathway

phospholipase c delta in phospholipid associated cell signaling;PID BioCarta;100071

Pathway

Calcium signaling pathway;KEGG PATHWAY;hsa04020

Pathway

Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Disease

Breast cancer;FunDO

Disease

Esophagus cancer;FunDO

External Links

Links to Entrez Gene

5333

Links to all GeneRIF Items

5333

Links to iHOP

5333

Sequence Information

Nucleotide Sequence

>5333 : length: 2334
atgcagtgcctggggatccggagccggagccgctccagggagctctacctgcaggagcgg
agccttaaggtggcggcgctcaatggacggaggctgggcctacaggatgatgaggatcta
caggcgctgctgaagggcagccagctcctgaaggtgaagtccagctcatggaggagagag
cgcttctacaagttgcaggaggactgcaagaccatctggcaggagtcccgcaaggtcatg
cggaccccggagtcccagctgttctccatcgaggacattcaggaggtgcgaatggggcac
cgcacggagggtctggagaagttcgcccgtgatgtgcccgaggaccgctgcttctccatt
gtcttcaaggaccagcgcaatacactagacctcatcgccccatcgccagctgatgcccag
cactgggtgctggggctgcacaagatcatccaccactcaggctccatggaccagcgtcag
aagctacagcactggattcactcctgcttgcgaaaagctgacaaaaacaaggacaacaag
atgagcttcaaggagctgcagaacttcctgaaggagctcaacatccaggtggacgacagc
tatgcccggaagatcttcagggagtgtgaccactcccagacagactccctggaggacgag
gagattgaggccttctacaagatgctgacccagcgggtggagatcgaccgcaccttcgcc
gaggccgcgggctcaggggagactctgtcggtggatcagttagtgacgttcctgcagcac
cagcagcgggaggaggcggcagggcctgcgctggccctctccctcattgagcgctacgag
cccagcgagactgccaaggcgcagcggcagatgaccaaggacggcttcctcatgtactta
ctgtcggctgacggcagcgccttcagcctggcacaccgccgtgtctaccaggacatgggc
cagccacttagccactacctggtgtcctcttcacacaacacctacctgctggaggaccag
ctagccgggcccagcagcactgaagcctacatccgggcactgtgcaaaggctgccgatgc
ctggagcttgactgctgggacgggcccaaccaggaaccaatcatctaccacggctatact
ttcacttccaagatcctcttctgcgatgtgctcagggccatccgggactatgccttcaag
gcgtccccctaccctgtcatcctatccctggagaaccactgcacactggagcagcagcgc
gtgatggcgcggcacctgcatgccatcctgggccccatgctgttgaaccgaccactggat
ggggtcaccaacagcctgccctcccctgagcaactgaaggggaagatcctgctgaagggg
aagaagctcggggggctcctgccccctggaggggagggtggccctgaggccactgtggtg
tcagacgaagacgaggctgctgagatggaggatgaggcagtgaggagccgtgtgcagcac
aagcccaaggaggacaagctcaggctagcacaggagctctctgacatggtcatttactgc
aagagtgtccactttgggggcttctccagtcctggcacccctggacaggccttctacgag
atggcgtccttctctgagaaccgtgcccttcgactgctccaagaatcaggaaacggcttt
gtccgccacaacgtggggcacctgagcagaatctacccggctggatggagaacagactcc
tccaactacagccccgtggagatgtggaatgggggctgccagatcgtggccctgaatttc
cagacacctgggccagagatggacgtgtaccagggccgcttccaggacaacggggcctgt
gggtacgtgctgaagcccgccttcctgcgagaccccaacggcacctttaacccccgcgcc
ctggctcaggggccctggtgggcacggaagcggctcaacatcagggtcatttcggggcag
cagctgccaaaagtcaacaagaataagaattcaattgtggaccccaaagtgacagtggag
atccatggcgtgagccgggacgtggccagccgccagactgctgtcatcaccaacaatggt
ttcaacccatggtgggacacggagtttgcgtttgaggtagttgtgcctgaccttgccctc
atccgcttcttggtggaagattatgatgcctcctccaagaatgacttcattggccagagt
accatccccttgaacagcctcaagcaaggataccgccatgtccacctcatgtctaagaac
ggggaccagcatccatcagccaccctctttgtgaagatctccctccaggactag

Protein Sequence

>5333 : length: 777
MQCLGIRSRSRSRELYLQERSLKVAALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWRRE
RFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSI
VFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNK
MSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFA
EAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYL
LSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRC
LELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQR
VMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVV
SDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYE
MASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNF
QTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQ
QLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLAL
IRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD



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