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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 6595 |
Name | SMARCA2 |
Synonym | BAF190|BRM|SNF2|SNF2L2|SNF2LA|SWI2|Sth1p|hBRM|hSNF2a;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2;SMARCA2;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
Definition | ATP-dependent helicase SMARCA2|BAF190B|BRG1-associated factor 190B|SNF2-alpha|SNF2-like 2|SNF2/SWI2-like protein 2|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2|SWI/SNF-related matrix-associated actin-dependent regulator of c |
Position | 9p22.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
potential | Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma. |
potential | This report provides supportive evidence that BRG1 and BRM act as tumor suppressor proteins and implicates a role for their loss in the development of non-small cell lung cancers. |
reviewed | Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling. |
| More detail of all 3 literatures about SMARCA2 | |
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Pathways and Diseases |
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Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | C-MYB transcription factor network;PID Curated;200130 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Disease | Schizophrenia;FunDO |
Disease | Adrenal gland tumor;FunDO |
Disease | Prostate cancer;FunDO |
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External Links |
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Links to Entrez Gene | 6595 |
Links to all GeneRIF Items | 6595 |
Links to iHOP | 6595 |
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Sequence Information |
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Nucleotide Sequence |
>6595 : length: 4773 atgtccacgcccacagaccctggtgcgatgccccacccagggccttcgccggggcctggg ccttcccctgggccaattcttgggcctagtccaggaccaggaccatccccaggttccgtc cacagcatgatggggccaagtcctggacctccaagtgtctcccatcctatgccgacgatg gggtccacagacttcccacaggaaggcatgcatcaaatgcataagcccatcgatggtata catgacaaggggattgtagaagacatccattgtggatccatgaagggcactggtatgcga ccacctcacccaggcatgggccctccccagagtccaatggatcaacacagccaaggttat atgtcaccacacccatctccattaggagccccagagcacgtctccagccctatgtctgga ggaggcccaactccacctcagatgccaccaagccagccgggggccctcatcccaggtgat ccgcaggccatgagccagcccaacagaggtccctcacctttcagtcctgtccagctgcat cagcttcgagctcagattttagcttataaaatgctggcccgaggccagcccctccccgaa acgctgcagcttgcagtccaggggaaaaggacgttgcctggcttgcagcaacaacagcag cagcaacagcagcagcagcagcagcagcagcagcagcagcagcagcaacagcagccgcag cagcagccgccgcaaccacagacgcagcaacaacagcagccggcccttgttaactacaac agaccatctggcccggggccggagctgagcggcccgagcaccccgcagaagctgccggtg cccgcgcccggcggccggccctcgcccgcgccccccgcagccgcgcagccgcccgcggcc gcagtgcccgggccctcagtgccgcagccggccccggggcagccctcgcccgtcctccag ctgcagcagaagcagagccgcatcagccccatccagaaaccgcaaggcctggaccccgtg gaaattctgcaagagcgggaatacagacttcaggcccgcatagctcataggatacaagaa ctggaaaatctgcctggctctttgccaccagatttaagaaccaaagcaaccgtggaacta aaagcacttcggttactcaatttccagcgtcagctgagacaggaggtggtggcctgcatg cgcagggacacgaccctggagacggctctcaactccaaagcatacaaacggagcaagcgc cagactctgagagaagctcgcatgaccgagaagctggagaagcagcagaagattgagcag gagaggaaacgccgtcagaaacaccaggaatacctgaacagtattttgcaacatgcaaaa gattttaaggaatatcatcggtctgtggccggaaagatccagaagctctccaaagcagtg gcaacttggcatgccaacactgaaagagagcagaagaaggagacagagcggattgaaaag gagagaatgcggcgactgatggctgaagatgaggagggttatagaaaactgattgatcaa aagaaagacaggcgtttagcttaccttttgcagcagaccgatgagtatgtagccaatctg accaatctggtttgggagcacaagcaagcccaggcagccaaagagaagaagaagaggagg aggaggaagaagaaggctgaggagaatgcagagggtggggagtctgccctgggaccggat ggagagcccatagatgagagcagccagatgagtgacctccctgtcaaagtgactcacaca gaaaccggcaaggttctgttcggaccagaagcacccaaagcaagtcagctggacgcctgg ctggaaatgaatcctggttatgaagttgcccctagatctgacagtgaagagagtgattct gattatgaggaagaggatgaggaagaagagtccagtaggcaggaaaccgaagagaaaata ctcctggatccaaatagcgaagaagtttctgagaaggatgctaagcagatcattgagaca gctaagcaagacgtggatgatgaatacagcatgcagtacagtgccaggggctcccagtcc tactacaccgtggctcatgccatctcggagagggtggagaaacagtctgccctcctaatt aatgggaccctaaagcattaccagctccagggcctggaatggatggtttccctgtataat aacaacttgaacggaatcttagccgatgaaatggggcttggaaagaccatacagaccatt gcactcatcacttatctgatggagcacaaaagactcaatggcccctatctcatcattgtt cccctttcgactctatctaactggacatatgaatttgacaaatgggctccttctgtggtg aagatttcttacaagggtactcctgccatgcgtcgctcccttgtcccccagctacggagt ggcaaattcaatgtcctcttgactacttatgagtatattataaaagacaagcacattctt gcaaagattcggtggaaatacatgatagtggacgaaggccaccgaatgaagaatcaccac tgcaagctgactcaggtcttgaacactcactatgtggcccccagaaggatcctcttgact gggaccccgctgcagaataagctccctgaactctgggccctcctcaacttcctcctccca acaatttttaagagctgcagcacatttgaacaatggttcaatgctccatttgccatgact ggtgaaagggtggacttaaatgaagaagaaactatattgatcatcaggcgtctacataag gtgttaagaccatttttactaaggagactgaagaaagaagttgaatcccagcttcccgaa aaagtggaatatgtgatcaagtgtgacatgtcagctctgcagaagattctgtatcgccat atgcaagccaaggggatccttctcacagatggttctgagaaagataagaaggggaaagga ggtgctaagacacttatgaacactattatgcagttgagaaaaatctgcaaccacccatat atgtttcagcacattgaggaatcctttgctgaacacctaggctattcaaatggggtcatc aatggggctgaactgtatcgggcctcagggaagtttgagctgcttgatcgtattctgcca aaattgagagcgactaatcaccgagtgctgcttttctgccagatgacatctctcatgacc atcatggaggattattttgcttttcggaacttcctttacctacgccttgatggcaccacc aagtctgaagatcgtgctgctttgctgaagaaattcaatgaacctggatcccagtatttc attttcttgctgagcacaagagctggtggcctgggcttaaatcttcaggcagctgataca gtggtcatctttgacagcgactggaatcctcatcaggatctgcaggcccaagaccgagct caccgcatcgggcagcagaacgaggtccgggtactgaggctctgtaccgtgaacagcgtg gaggaaaagatcctcgcggccgcaaaatacaagctgaacgtggatcagaaagtgatccag gcgggcatgtttgaccaaaagtcttcaagccacgagcggagggcattcctgcaggccatc ttggagcatgaggaggaaaatgaggaagaagatgaagtaccggacgatgagactctgaac caaatgattgctcgacgagaagaagaatttgacctttttatgcggatggacatggaccgg cggagggaagatgcccggaacccgaaacggaagccccgtttaatggaggaggatgagctg ccctcctggatcattaaggatgacgctgaagtagaaaggctcacctgtgaagaagaggag gagaaaatatttgggagggggtcccgccagcgccgtgacgtggactacagtgacgccctc acggagaagcagtggctaagggccatcgaagacggcaatttggaggaaatggaagaggaa gtacggcttaagaagcgaaaaagacgaagaaatgtggataaagatcctgcaaaagaagat gtggaaaaagctaagaagagaagaggccgccctcccgctgagaaactgtcaccaaatccc cccaaactgacaaagcagatgaacgctatcatcgatactgtgataaactacaaagatagg tgtaacgtggagaaggtgcccagtaattctcagttggaaatagaaggaaacagttcaggg cgacagctcagtgaagtcttcattcagttaccttcaaggaaagaattaccagaatactat gaattaattaggaagccagtggatttcaaaaaaataaaggaaaggattcgtaatcataag taccggagcctaggcgacctggagaaggatgtcatgcttctctgtcacaacgctcagacg ttcaacctggagggatcccagatctatgaagactccatcgtcttacagtcagtgtttaag agtgcccggcagaaaattgccaaagaggaagagagtgaggatgaaagcaatgaagaggag gaagaggaagatgaagaagagtcagagtccgaggcaaaatcagtcaaggtgaaaattaag ctcaataaaaaagatgacaaaggccgggacaaagggaaaggcaagaaaaggccaaatcga ggaaaagccaaacctgtagtgagcgattttgacagcgatgaggagcaggatgaacgtgaa cagtcagaaggaagtgggacggatgatgagtga |
Protein Sequence |
>6595 : length: 1590 MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP PKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKELPEYY ELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFK SARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNR GKAKPVVSDFDSDEEQDEREQSEGSGTDDE |