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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8678 |
Name | BECN1 |
Synonym | ATG6|VPS30|beclin1;beclin 1, autophagy related;BECN1;beclin 1, autophagy related |
Definition | ATG6 autophagy related 6 homolog|beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)|beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)|beclin-1|coiled-coil myosin-like BCL2-interacting protein |
Position | 17q21 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 5 PubMed records as below. |
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Evidence Status |
Description |
potential | "Evolutionarily conserved domain of Beclin 1 is essential for Vps34 interaction, autophagy function, and tumor suppressor function." |
reviewed | Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. |
potential | "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21." |
reviewed | Control of autophagy by oncogenes and tumor suppressor genes. |
reviewed | "Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor." |
potential | "Findings suggest a positive feedback loop for recruitment of FYVE-CENT and Beclin 1 to the intercellular bridge during cytokinesis, and reveal a novel potential tumor suppressor mechanism for Beclin 1." |
| More detail of all 5 literatures about BECN1 | |
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Pathways and Diseases |
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Pathway | Regulation of autophagy;KEGG PATHWAY;hsa04140 |
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External Links |
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Links to Entrez Gene | 8678 |
Links to all GeneRIF Items | 8678 |
Links to iHOP | 8678 |
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Sequence Information |
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Nucleotide Sequence |
>8678 : length: 1353 atggaagggtctaagacgtccaacaacagcaccatgcaggtgagcttcgtgtgccagcgc tgcagccagcccctgaaactggacacgagtttcaagatcctggaccgtgtcaccatccag gaactcacagctccattacttaccacagcccaggcgaaaccaggagagacccaggaggaa gagactaactcaggagaggagccatttattgaaactcctcgccaggatggtgtctctcgc agattcatccccccagccaggatgatgtccacagaaagtgccaacagcttcactctgatt ggggaggcatctgatggcggcaccatggagaacctcagccgaagactgaaggtcactggg gacctttttgacatcatgtcgggccagacagatgtggatcacccactctgtgaggaatgc acagatactcttttagaccagctggacactcagctcaacgtcactgaaaatgagtgtcag aactacaaacgctgtttggagatcttagagcaaatgaatgaggatgacagtgaacagtta cagatggagctaaaggagctggcactagaggaggagaggctgatccaggagctggaagac gtggaaaagaaccgcaagatagtggcagaaaatctcgagaaggtccaggctgaggctgag agactggatcaggaggaagctcagtatcagagagaatacagtgaatttaaacgacagcag ctggagctggatgatgagctgaagagtgttgaaaaccagatgcgttatgcccagacgcag ctggataagctgaagaaaaccaacgtctttaatgcaaccttccacatctggcacagtgga cagtttggcacaatcaataacttcaggctgggtcgcctgcccagtgttcccgtggaatgg aatgagattaatgctgcttggggccagactgtgttgctgctccatgctctggccaataag atgggtctgaaatttcagagataccgacttgttccttacggaaaccattcatatctggag tctctgacagacaaatctaaggagctgccgttatactgttctggggggttgcggtttttc tgggacaacaagtttgaccatgcaatggtggctttcctggactgtgtgcagcagttcaaa gaagaggttgagaaaggcgagacacgtttttgtcttccctacaggatggatgtggagaaa ggcaagattgaagacacaggaggcagtggcggctcctattccatcaaaacccagtttaac tctgaggagcagtggacaaaagctctcaagttcatgctgacgaatcttaagtggggtctt gcttgggtgtcctcacaattttataacaaatga |
Protein Sequence |
>8678 : length: 450 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN SEEQWTKALKFMLTNLKWGLAWVSSQFYNK |