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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 90627 |
Name | STARD13 |
Synonym | ARHGAP37|DLC2|GT650;StAR-related lipid transfer (START) domain containing 13;STARD13;StAR-related lipid transfer (START) domain containing 13 |
Definition | 46H23.2|DLC-2|Rho GTPase activating protein on chromosome 13q12|deleted in liver cancer 2 protein|stAR-related lipid transfer protein 13 |
Position | 13q12-q13 |
Gene Type | protein-coding |
Source | Count: 2; UniProt,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Phosphorylation of deleted in liver cancer 1 (DLC1) and DLC2 by Akt at the conserved residue points to a common regulatory mechanism of the DLC tumor suppressor family. |
reviewed | Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. |
reviewed | "Results suggest that DLC2 exhibits its tumor suppressor functions in vivo as a GAP specific for RhoA, exerting its effects in suppression of cytoskeleton reorganization, cell growth, cell migration, and transformation." |
potential | "Results suggest that DLC2 exhibits its tumor suppressor functions in vivo as a GAP specific for RhoA, exerting its effects in suppression of cytoskeleton reorganization, cell growth, cell migration, and transformation." |
| More detail of all 3 literatures about STARD13 | |
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Pathways and Diseases |
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Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Disease | Intracranial aneurysm;NHGRI |
Disease | smoking cessation;GAD |
Disease | CHEMDEPENDENCY;GAD |
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External Links |
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Links to Entrez Gene | 90627 |
Links to all GeneRIF Items | 90627 |
Links to iHOP | 90627 |
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Sequence Information |
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Nucleotide Sequence |
>90627 : length: 2988 atgaaacttgatgtgaacttccaaaggaaaaagggtgacgactccgatgaggaagatctt tgtatcagcaacaaatggactttccaaagaaccagtcgcaggtggtctcgtgtggacgac ctctacacgctgctccctcgaggagacagaaatgggtcaccgggaggcacggggatgagg aacacgaccagcagtgagagcgtcctcacagacctgagcgagcctgaggtctgctccatt cacagcgaaagcagtggaggcagcgacagtcgcagccagccgggccagtgctgtacagac aacccggtcatgctggatgccccactcgtcagcagcagcctcccacagccccccagagat gtcctcaaccaccccttccaccccaagaatgagaagcccacgagggctagggccaaatca tttttgaaacgcatggaaacactccgagggaagggagcccacgggaggcataaggggtct gggcggacaggtggcctggtgatcagtgggcccatgttgcagcaggagccagagtccttt aaggctatgcagtgcatccaaataccaaatggagatctccagaattcgccgccacctgcc tgcagaaaagggctcccatgctctggcaagtcgagtggcgagagcagcccgtcggagcac agcagcagcggggtgagcacgccctgcctgaaggaacgcaagtgccacgaggccaacaag cgcgggggcatgtacttggaggacctagatgtgctggcggggacagcactgccggatgca ggggaccaaagccgtatgcatgaatttcactcccaagagaatttggtggtgcatattccc aaggatcacaaaccaggaacattccccaaggcactttctattgaaagcctctctcccaca gatagtagcaatggggttaattggaggaccggtagcatctccctgggcagagagcaggtc cctggtgccagggagccccggctcatggcgtcctgccacagagccagccgagtcagtatc tatgacaatgtccctggctcccatctgtatgccagcacaggagatcttttggacttggag aaagatgaccttttccctcacttggatgacattctgcagcatgtcaatgggctccaagag gtagtcgatgactggtccaaagatgtcttgcctgaactgcaaactcatgatacattggtt ggggaacctggcttatccacctttccatctcctaatcagatcaccttagattttgaaggt aactctgtctcagaaggtcggacgacacccagtgatgtggaaagagatgtaacatctctt aatgaatctgagcctcctggggtcagagacaggagggattctggtgtaggggcctctctg accaggccaaacaggcgactccgatggaacagtttccagctgtcgcaccagccccggccg gccccagcatcgccccacatcagcagccagacggccagccagctgagcctgctccagcgc ttctcactgctccgcctcacggccatcatggagaagcactccatgtccaacaagcacggc tggacatggtcagttccaaagttcatgaagaggatgaaagttcccgactacaaagacaag gctgtctttggcgttcctctcatagtccacgtccaaagaacgggacagcccctgcctcaa agtattcagcaagcactgagatatctacgcagcaactgcctcgatcaggtgggtcttttt cgcaaatcaggagtgaagtctcgaatccatgcccttcgccaaatgaatgaaaacttccct gagaacgtcaactatgaagaccagtctgcttatgatgtggcggatatggtgaaacagttc ttccgggacctccctgagcctcttttcaccaacaagctcagtgagacctttctccatatc tatcagtatgtctccaaagagcagcggctgcaggccgtgcaggctgccatcctgctactg gccgatgagaacagggaggtcctgcagacgctcttgtgtttcctgaacgacgtcgtcaac ttggtggaagagaatcagatgacgcccatgaacctggcagtgtgtctggccccctccctc tttcatcttaatttattgaagaaagaaagctctccacgagtcatacagaagaaatatgcc actgggaagccagatcaaaaggacctcaacgagaatctggcagcagctcaggggctagcg cacatgatcatggaatgcgacagactttttgaggttccacacgagttggtggcccagtct cgtaactcgtatgtggaggctgagatccacgtgccaaccctggaagaattggggacacag ctggaggagagtggggcaactttccacacttacctgaaccatctcatccagggcctccag aaagaagccaaggagaagttcaaaggatgggtcacgtgctccagcacggacaatacagat cttgctttcaaaaaggtgggcgacgggaacccgctgaagctgtggaaggcttctgtggag gtggaagcacccccctcagtggtcctgaaccgcgtgctgagagagcgccacctgtgggac gaggactttgtgcagtggaaggttgtggaaactctagacaggcaaacagagatctaccag tatgtgctgaacagcatggctccccatccttccagagactttgtggttctcaggacctgg aaaactgatttgcccaaaggaatgtgtaccctggtgtccctctccgtggagcatgaggaa gcccagctcctgggtggtgtgcgagcagtggtgatggactcgcagtacttgatagaaccg tgtggctctggcaagtcaagactgactcacatctgcaggatagacctgaaaggtcactcc ccagaatggtacagcaaaggctttggacatctgtgtgcagcagaagttgccaggattaga aactctttccagcccctcattgctgagggcccagaaactaaaatctga |
Protein Sequence |
>90627 : length: 995 MKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTLLPRGDRNGSPGGTGMR NTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNPVMLDAPLVSSSLPQPPRD VLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGSGRTGGLVISGPMLQQEPESF KAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPSEHSSSGVSTPCLKERKCHEANK RGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLVVHIPKDHKPGTFPKALSIESLSPT DSSNGVNWRTGSISLGREQVPGAREPRLMASCHRASRVSIYDNVPGSHLYASTGDLLDLE KDDLFPHLDDILQHVNGLQEVVDDWSKDVLPELQTHDTLVGEPGLSTFPSPNQITLDFEG NSVSEGRTTPSDVERDVTSLNESEPPGVRDRRDSGVGASLTRPNRRLRWNSFQLSHQPRP APASPHISSQTASQLSLLQRFSLLRLTAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDK AVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFP ENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLL ADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYA TGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQ LEESGATFHTYLNHLIQGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVE VEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTW KTDLPKGMCTLVSLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHS PEWYSKGFGHLCAAEVARIRNSFQPLIAEGPETKI |