|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 9940 |
Name | DLEC1 |
Synonym | DLC1|F56;deleted in lung and esophageal cancer 1;DLEC1;deleted in lung and esophageal cancer 1 |
Definition | DLC-1|deleted in lung and esophageal cancer 1 transcript varient 2|deleted in lung and esophageal cancer protein 1 |
Position | 3p21.3 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 4 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | "DLEC1 is often down-regulated by CpG methylation and shows tumor inhibitory function in renal cell carcinoma cells, indicating its role as a tumor suppressor". |
potential | DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma. |
potential | Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer. |
potential | "Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3." |
| More detail of all 4 literatures about DLEC1 | |
|
External Links |
|
Links to Entrez Gene | 9940 |
Links to all GeneRIF Items | 9940 |
Links to iHOP | 9940 |
|
Sequence Information |
|
Nucleotide Sequence |
>9940 : length: 5268 atggagaccaggagctccaaaacgcggaggtctttagcgtcccggaccaacgagtgccag gggacaatgtgggcgccaacttcgccaccagccgggtccagcagccccagccagcccacc tggaagtcctccttgtattcctccctcgcctactctgaggccttccactacagcttcgca gcccggccccgccgcctcacgcagcttgcgctggcgcagcgtcccgagcctcagctgctt cgtctgcgcccctcctcgctgcgcacccaagatatctcgcacttgctcaccggcgtcttc cgcaacttgtactcagccgaggtcatcggcgacgaagtgagcgcaagcttgatcaaggcc cgcggcagcgagaatgagcgccacgaggagttcgtggaccagctgcagcagattcgggag ctctataagcagcggctggatgagtttgaaatgttggagagacatatcactcaggcccaa gcacgggctattgcggaaaatgagcgggtcatgagccaggctggagtacaggacctcgag agccttgtcaggttgcctccagtgaagagtgtctccagatggtgtatagacagcgagttg ctacggaaacatcatttgatctccccagaagattactacaccgatacagtgccgtttcac tctgcacctaaaggcatctccctacctggatgttcaaaactgacatttagctgtgagaag cgttccgtccagaagaaagagctgaacaagaagcttgaagattcatgcaggaagaagctt gctgagttcgaagatgagttagaccacactgtggacagcctgacatggaatttaactcct aaggccaaagaaaggaccagagaacctctcaagaaagcaagtcaaccaaggaataaaaac tggatgaaccacttacgtgtgccacagagagagctagacagacttctgcttgccagaatg gagagtcggaaccacttcctaaaaaatccccgtttttttcctcctaacactcgatatgga ggcaagtctcttgtttttcctccaaagaagccagcaccgataggagaattccagagtaca gagccagaacagagttgtgctgatactccagtgtttctagctaagccaccaattgggttt ttcacagattatgaaattggtccagtttatgagatggtaattgcgctgcagaacaccacc acgaccagccgctacctgcgagtcctcccgccttccacgccatacttcgctctgggactg gggatgttcccaggaaaaggtggaatggtggctcctggaatgacctgccagtacattgtc cagttttttcccgactgccttggggattttgatgattttattttagtggagacccagtca gcccacacacttctgatccccctgcaggcccggaggccgccccccgtgctgacattgtca ccggtgttggactgtggttactgcctcattgggggagtcaagatgaccagattcatctgc aaaaatgtgggtttcagtgttggcaggttctgcattatgcccaaaacaagctggccacca ctaagtttcaaggccattgcaaccgtcggctttgttgaacaacctccttttggaatcctg ccttcggtgtttgagctggccccgggacatgctatattagtggaggtcttgttttcccca aagagcctaggaaaggcagagcagaccttcatcatcatgtgcgacaactgccagataaag gagctggtgaccataggaattgggcagctgattgctttggatctgatctatatttctggt gaaaaaagccagccagaccctggagagctcacagacttaacagcccagcacttcatacga tttgagcctgaaaaccttcggtccacggctaggaagcagctgattattagaaatgctacg cacgtggagctggccttctactggcagatcatgaagcccaacctgcagcccctcatgcct ggagaaaccttcagcatggacagcatcaagtgctaccccgacaaggagactgccttctcc atcatgcccagaaagggggttctaagcccccacacagaccacgagttcatcctgagcttt tctcctcatgagctgagggattttcacagtgtgctccagatggtgctagaggaagtccca gagcctgtaagttcagaagcggagagcctggggcactcctcctactctgtggatgatgtg attgtcctggaaatcgaggtgaaaggctcagtagaacctttccaggttctcttagagcca tatgccctcatcatcccaggggagaactacattgggataaatgtgaagaaggcttttaag atgtggaacaacagcaagtcacccatcagatacctgtgggggaagatcagcgactgccac atcattgaagtggagcccggcacaggggtcatagagcccagtgaggtcggggattttgag ttgaactttactgggggtgtccctggccccacaagccaggacctgctgtgtgaaatcgaa gactcgccctcgccagtggtgttacacattgaggctgtctttaaggggcctgccctcatc atcaacgtctcagcccttcagtttggtctgctccgcctggggcagaaagccacaaactcc atccagatccggaacgtcagccagctcccagccacatggcgcatgaaggagagcccagtc tccctccaggaaaggcctgaggatgtgtctcccttcgacattgagccttcgagtggccag cttcactctctgggggagtgcagggtggacatcaccttggaggccctgcactgccagcat ctggagaccgtcctggagctggaggtggaaaatggtgcctggagctaccttcctgtgtat gctgaggtacagaagccccatgtgtacctacagagcagccaggtggaggttagaaatctc tacctgggtgtgcccacgaagacaaccatcacacttatcaatggcacgctcctgcctacc cagttccactggggcaagctcctcggacaccaagcagaattctgcatggtgacagtctcc cccaaacatggcctgctgggcccaagtgaggagtgccagctcaagttggagttgactgct catacccaggaagagctgacccatctggccctcccttgtcacgtgtcaggcatgaagaag ccactggttctaggcatttctgggaagccccagggactgcaagtggccattaccatctct aaggagagctctgattgcagcacagagcagtggccaggccacccaaaggagctccgcctg gactttggctcagcggtgccactgaggacccgtgtgactcgccagctcattctcaccaat cgctccccaatacggacccgtttctccctcaagtttgagtatttcgggagcccccaaaac agcctgagcaaaaagaccagccttcccaacatgcctcctgccctgctaaagacagtgcgg atgcaagagcacctggccaagcgagagcagctggattttatggagagcatgctatcccac gggaaaggagctgctttcttccctcacttttcccagggcatgctggggccctaccagcag ctgtgcattgacatcacaggctgtgccaacatgtggggcgagtactgggacaacctcatc tgcacggtgggagacctgctgccggaagtcatcccagtgcacatggcagcggtgggctgc cccatcagctccctgaggaccacctcctacactattgaccaggcccagaaggaaccagcc atgaggttcggcacccaggtctccggaggagacacagttacccgaacccttcgcctgaat aactccagcccctgtgacatccgcctggattgggagacctatgttccagaagacaaggaa gaccggctggtggagctgctggtgttttatgggccacctttcccgctgcgggaccaagcc gggaatgagcttgtgtgccctgatacccctgagggtggctgcctcctctggtccccaggc ccctccagttcatcggaattcagccatgaaactgactcatcagttgagggcagctccagt gccagcaatagggtggcacagaagctcatctcagtcatcctgcaggcacatgagggggtg ccctccggccacctgtactgtatcagccccaagcaggtggtggtccctgctgggggcagc agtaccatctacatctccttcacccctatggtgctcagccctgagatcctgcacaaggtg gagtgtactggctacgccctgggtttcatgagcttggacagcaaggtggaaagggagatt ccagggaagaggcatcgcctgcaggactttgcggtgggacccctgaaactggacctgcat agctacgtgaggcctgcacagctaagtgtggagctggactacggcggcagtatggaattc cagtgccaggccagtgacctcattcccgagcagccctgctctggggtgctgagtgagctg gtgaccacccaccacctgaagctgaccaacactacagagatcccacactacttccggctt atggtctccaggcccttctccgtttctcaagatggggcgagccaggaccacagagctcct ggccctggccagaagcaggagtgtgaggaggagacagcctcagcggacaagcagctggtg ctccaagcacaggagaacatgctggtgaacgtgtccttctcactctccctggagctgctc tcctatcagaagctcccagctgaccagacactgcctggggtggacattcagcagagtgcg agtggagagagagagatggtgtttactcagaacctgctcctggagtacaccaaccagacc actcaggtggtgcccctgcgggctgtggtggccgtgcctgagctgcagctctccaccagc tgggtggactttgggacctgctttgtgagccagcagcgagtccgggaggtctacctgatg aacctgagcgggtgccgaagctactggactatgctgatgggccagcaggagccagccaag gccgctgtggccttcagggtctccccaaacagtgggctgctagaagcacgatccgccaat gcacccccaacctccatcgccttgcaggttttcttcactgccaggagtagtgagctgtac gagtccacgatggtggtggaaggtgtgctcggtgagaagtcctgcaccctgcggctccgg ggccaaggctcctatgatgagagatacatgttgcctcaccagccctga |
Protein Sequence |
>9940 : length: 1755 METRSSKTRRSLASRTNECQGTMWAPTSPPAGSSSPSQPTWKSSLYSSLAYSEAFHYSFA ARPRRLTQLALAQRPEPQLLRLRPSSLRTQDISHLLTGVFRNLYSAEVIGDEVSASLIKA RGSENERHEEFVDQLQQIRELYKQRLDEFEMLERHITQAQARAIAENERVMSQAGVQDLE SLVRLPPVKSVSRWCIDSELLRKHHLISPEDYYTDTVPFHSAPKGISLPGCSKLTFSCEK RSVQKKELNKKLEDSCRKKLAEFEDELDHTVDSLTWNLTPKAKERTREPLKKASQPRNKN WMNHLRVPQRELDRLLLARMESRNHFLKNPRFFPPNTRYGGKSLVFPPKKPAPIGEFQST EPEQSCADTPVFLAKPPIGFFTDYEIGPVYEMVIALQNTTTTSRYLRVLPPSTPYFALGL GMFPGKGGMVAPGMTCQYIVQFFPDCLGDFDDFILVETQSAHTLLIPLQARRPPPVLTLS PVLDCGYCLIGGVKMTRFICKNVGFSVGRFCIMPKTSWPPLSFKAIATVGFVEQPPFGIL PSVFELAPGHAILVEVLFSPKSLGKAEQTFIIMCDNCQIKELVTIGIGQLIALDLIYISG EKSQPDPGELTDLTAQHFIRFEPENLRSTARKQLIIRNATHVELAFYWQIMKPNLQPLMP GETFSMDSIKCYPDKETAFSIMPRKGVLSPHTDHEFILSFSPHELRDFHSVLQMVLEEVP EPVSSEAESLGHSSYSVDDVIVLEIEVKGSVEPFQVLLEPYALIIPGENYIGINVKKAFK MWNNSKSPIRYLWGKISDCHIIEVEPGTGVIEPSEVGDFELNFTGGVPGPTSQDLLCEIE DSPSPVVLHIEAVFKGPALIINVSALQFGLLRLGQKATNSIQIRNVSQLPATWRMKESPV SLQERPEDVSPFDIEPSSGQLHSLGECRVDITLEALHCQHLETVLELEVENGAWSYLPVY AEVQKPHVYLQSSQVEVRNLYLGVPTKTTITLINGTLLPTQFHWGKLLGHQAEFCMVTVS PKHGLLGPSEECQLKLELTAHTQEELTHLALPCHVSGMKKPLVLGISGKPQGLQVAITIS KESSDCSTEQWPGHPKELRLDFGSAVPLRTRVTRQLILTNRSPIRTRFSLKFEYFGSPQN SLSKKTSLPNMPPALLKTVRMQEHLAKREQLDFMESMLSHGKGAAFFPHFSQGMLGPYQQ LCIDITGCANMWGEYWDNLICTVGDLLPEVIPVHMAAVGCPISSLRTTSYTIDQAQKEPA MRFGTQVSGGDTVTRTLRLNNSSPCDIRLDWETYVPEDKEDRLVELLVFYGPPFPLRDQA GNELVCPDTPEGGCLLWSPGPSSSSEFSHETDSSVEGSSSASNRVAQKLISVILQAHEGV PSGHLYCISPKQVVVPAGGSSTIYISFTPMVLSPEILHKVECTGYALGFMSLDSKVEREI PGKRHRLQDFAVGPLKLDLHSYVRPAQLSVELDYGGSMEFQCQASDLIPEQPCSGVLSEL VTTHHLKLTNTTEIPHYFRLMVSRPFSVSQDGASQDHRAPGPGQKQECEEETASADKQLV LQAQENMLVNVSFSLSLELLSYQKLPADQTLPGVDIQQSASGEREMVFTQNLLLEYTNQT TQVVPLRAVVAVPELQLSTSWVDFGTCFVSQQRVREVYLMNLSGCRSYWTMLMGQQEPAK AAVAFRVSPNSGLLEARSANAPPTSIALQVFFTARSSELYESTMVVEGVLGEKSCTLRLR GQGSYDERYMLPHQP |