Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

4804

Name

NGFR

Synonymous

CD271|Gp80-LNGFR|TNFRSF16|p75(NTR)|p75NTR;nerve growth factor receptor;NGFR;nerve growth factor receptor

Definition

NGF receptor|TNFR superfamily, member 16|low affinity nerve growth factor receptor|low affinity neurotrophin receptor p75NTR|low-affinity nerve growth factor receptor|p75 ICD|tumor necrosis factor receptor superfamily member 16

Position

17q21-q22

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

   | Top |

Regulation From TransFac database

caveolin-1(m) + p75NTR(h) <==> caveolin-1(m):p75NTR(h) (binding)
p75NTR(h) --gamma-secretase(h)--> p75NTR-CTF(h) + p75NTR-ICD(h) (processing)
Fas(h) + p75NTR(h) <==> Fas(h):p75NTR(h) (binding)
p75NTR(h) + BDNF(r) <==> p75NTR(h):BDNF(r) (binding)
BDNF(m) + p75NTR(h) <==> BDNF(m):p75NTR(h) (binding)
NGF(r) + p75NTR(h) <==> NGF(r):p75NTR(h) (binding)
NT-3(r) + p75NTR(h) <==> NT-3(r):p75NTR(h) (binding)
NT-5(r) + p75NTR(h) <==> NT-5(r):p75NTR(h) (binding)
TRADD(h) + p75NTR(h) <==> TRADD(h):p75NTR(h) (binding)
TRADD(h) + p75NTR(h) <==> TRADD(h):p75NTR(h) (binding)
p75NTR(h) --> p75NTR-ICD(h) + protein remnants (processing)
p75NTR(h) --> p75NTR-CTF(h) + protein remnants (processing)
p75NTR(h) + CTGF(h) <==> p75NTR(h):CTGF(h) (binding)
NGFR(h) --> p75NTR(h) (expression).
trkA(r) + p75NTR(h) <==> trkA(r):p75NTR(h) (binding)
trkA(r){p} + p75NTR(h) <==> trkA(r){p}:p75NTR(h) (binding)
Necdin(m) + p75NTR(h) <==> Necdin(m):p75NTR(h) (binding)
MAGEG1(m) + p75NTR(h) <==> MAGEG1(m):p75NTR(h) (binding)
SC-1(r) + p75NTR(h) <==> SC-1(r):p75NTR(h) (binding)
p75NTR(h) + RanBPM(m) <==> p75NTR(h):RanBPM(m) (binding)
RanBPM(m) + p75NTR(h) <==> RanBPM(m):p75NTR(h) (binding)
p75NTR(h) + PKAc-beta-isoform5(h) <==> p75NTR(h):PKAc-beta-isoform5(h) (binding)
PKAc-beta(h) + p75NTR(h) <==> PKAc-beta(h):p75NTR(h) (binding)
p75NTR(h) + ATP --PKAc(b)--> p75NTR(h){pS303} + ADP (phosphorylation)
p75NTR(h) + ATP --> p75NTR(h){pS303} + ADP (phosphorylation)
p75NTR(h) + NgR(m.s.) <==> p75NTR(h):NgR(m.s.) (binding)
p75NTR(h) + 14-3-3epsilon(m) + NADE-isoform1(m) <==> p75NTR(h):14-3-3epsilon(m):NADE-isoform1(m) (binding)
p75NTR(h) + RhoA(m.s.) + RhoGDI-1(h) <==> p75NTR(h):RhoA(m.s.):RhoGDI-1(h) (binding)
RhoGDI-1(m) + RhoA(m.s.) + p75NTR(h) <==> RhoGDI-1(m):RhoA(m.s.):p75NTR(h) (binding)
RhoGDI-1(h) + p75NTR(h) <==> RhoGDI-1(h):p75NTR(h) (binding)
p75NTR(h) --> p75NTR-ICD(h) + protein remnants (processing)
p75NTR(h) --> p75NTR-CTF(h) + protein remnants (processing)
p75NTR(h) + GT1b <==> p75NTR(h):GT1b (binding)
p75NTR(h) --TACE(m)--> p75NTR-ECD(h) + protein remnants (cleavage)
NGFR(h) --> p75NTR(h) (expression).

Post Transcriptional Modification From dbPTM

   | Top |

Location (AA)

PTM type

Literature

Database

Methylation Profile From DiseaseMeth database

   | Top |

Chromosome

Location

Source

chr17

Promoter: 44926166 - 44928166Agilent_014791

chr17

Promoter: 44926166 - 44928166GoldenGate_Methylation_Cancer_Panel_I

chr17

Promoter: 44926166 - 44928166GSE27584

chr17

Promoter: 44926166 - 44928166Agilent_014791_44K


Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston Rights Reserved
Site Policies | State of Texas