Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

6925

Name

TCF4

Synonymous

E2-2|ITF-2|ITF2|PTHS|SEF-2|SEF2|SEF2-1|SEF2-1A|SEF2-1B|TCF-4|bHLHb19;transcription factor 4;TCF4;transcription factor 4

Definition

SL3-3 enhancer factor 2|class B basic helix-loop-helix protein 19|immunoglobulin transcription factor 2

Position

18q21.1

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

ITF-2(h) + Id1(m) <==> ITF-2(h):Id1(m) (binding).
ITF-2(h) + ITF-1(h) <==> ITF-2(h):ITF-1(h) (binding).
Tal1-PP42(h) + ITF-2(h) <==> Tal1-PP42(h):ITF-2(h) (binding).
Tal1-PP22(h) + ITF-2(h) <==> Tal1-PP22(h):ITF-2(h) (binding).
ITF-2(h) + MyoD(h) <==> ITF-2(h):MyoD(h) (binding).
ITF-2(h) + MEF1(m) <==> ITF-2(h):MEF1(m) (binding).
ITF-2(h) + Myogenin(h) <==> ITF-2(h):Myogenin(h) (binding).
ITF-2(h) + Myf-5(h) <==> ITF-2(h):Myf-5(h) (binding).
ITF-2(h) + Myf-6(h) <==> ITF-2(h):Myf-6(h) (binding).
ITF-2(h) + MyoD(x) <==> ITF-2(h):MyoD(x) (binding).
ITF-2(h) + MyoD(m) <==> ITF-2(h):MyoD(m) (binding).
ITF-2(h) + MyoD(mo) <==> ITF-2(h):MyoD(mo) (binding).
Myf-5(x) + ITF-2(h) <==> Myf-5(x):ITF-2(h) (binding).
MyoD(c) + ITF-2(h) <==> MyoD(c):ITF-2(h) (binding).
HTF4(h) + ITF-2(h) <==> HTF4(h):ITF-2(h) (binding).
Id1.25(r) + ITF-2(h) <==> Id1.25(r):ITF-2(h) (binding).
Id1(r) + ITF-2(h) <==> Id1(r):ITF-2(h) (binding).
PIAS1(h) + ITF-2(h) <==> PIAS1(h):ITF-2(h) (binding)
ITF-2(h) + PIAS2-beta(h) <==> ITF-2(h):PIAS2-beta(h) (binding)
ITF-2(h) + PIAS1(m) <==> ITF-2(h):PIAS1(m) (binding)
Id2(h) + ITF-2(h) <==> Id2(h):ITF-2(h) (binding)
Id3(h) + ITF-2(h) <==> Id3(h):ITF-2(h) (binding)
ITF-2(h) + msc(h) <==> ITF-2(h):msc(h) (binding)
ITF-2(h) + hbp1(h) <==> ITF-2(h):hbp1(h) (binding)
TCF4(h) --> ITF-2(h) (expression).
SEF2-1B(h) --> CKM(m) (DNA binding).
SEF2-1B(h) --> MLC(r) (DNA binding).
SEF2-1B(h) --> IgH(m) (DNA binding).
SEF2-1B(h) --> AMHR2(h) (DNA binding; transactivation).
TCF4(h) --> SEF2-1B(h) (expression).
TCF4(h) --> SEF2-1A(h) (expression).
TCF4(h) --> SEF2-1D(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

54Phosphoserine (CK2 alpha)11711551Phospho.ELM 6.0
55Phosphoserine (CK2 alpha)11711551Phospho.ELM 6.0
56Phosphoserine (CK2 alpha)11711551Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr18

Promoter: 51405941 - 51407941Agilent_014791

chr18

Promoter: 51405941 - 51407941GoldenGate_Methylation_Cancer_Panel_I

chr18

Promoter: 51405941 - 51407941GSE27584


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