Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7128

Name

TNFAIP3

Synonymous

A20|OTUD7C|TNFA1P2;tumor necrosis factor, alpha-induced protein 3;TNFAIP3;tumor necrosis factor, alpha-induced protein 3

Definition

OTU domain-containing protein 7C|TNF alpha-induced protein 3|TNFAIP3 (A20)|putative DNA-binding protein A20|tumor necrosis factor alpha-induced protein 3|tumor necrosis factor inducible protein A20|zinc finger protein A20

Position

6q23

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

A20(h) + IKK-gamma(h) <==> A20(h):IKK-gamma(h) (binding)
A20(h) + TRAF1(m) + TRAF2(m) <==> A20(h):TRAF1(m):TRAF2(m) (binding)
TNFR1(h) + A20(h) <==> TNFR1(h):A20(h) (binding)
TNFR1(h) + RIP(h) + A20(h) + IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2 <==> TNFR1(h):RIP(h):IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2:A20(h) (binding)
A20(h) + 14-3-3beta(h) <==> A20(h):14-3-3beta(h) (binding)
A20(h) + 14-3-3zeta(h) <==> A20(h):14-3-3zeta(h) (binding)
A20(h) + 14-3-3eta(h) <==> A20(h):14-3-3eta(h) (binding)
A20(h) + 14-3-3gamma(h) <==> A20(h):14-3-3gamma(h) (binding)
A20(h) + 14-3-3epsilon(h) <==> A20(h):14-3-3epsilon(h) (binding)
A20(h) + 14-3-3(h) + Raf-1(h) <==> A20(h):14-3-3(h):Raf-1(h) (binding)
A20(h) + ATP --IKK-beta(h)--> A20(h){pS381} + ADP (phosphorylation)
A20(h) --> A20-p37(h) + protein remnants (cleavage)
A20(h) + MALT1(h):bcl10(h) <==> A20(h):MALT1(h):bcl10(h) (binding)
A20(h) --> IL-2(h) (decrease of secretion)
A20(h) --> A20-p50(h) + A20-p37(h) (cleavage)
A20(h) --> JNK(h){pT}{pY} (decrease of phosphorylation)
A20(h) --> IkappaB-alpha(h){pS32} (decrease of phosphorylation)
RIP(h) + A20(h) <==> RIP(h):A20(h) (binding)
TNFAIP3(h) --> A20(h) (expression).
TICAM(m.s.) + A20(h) <==> TICAM(m.s.):A20(h) (binding)
A20(h) + n ubiquitin(h) --> A20(h){ub}n (ubiquitination)
A20(h) + n ubiquitin(h) --> A20(h){ub{K48}(n)} (ubiquitination; automodification)
A20(h) + RIP(h) <==> A20(h):RIP(h) (binding)
A20(h) --> RIP(h){ub{K63}(n)} (decrease of ubiquitination)
A20(h) --> RIP(m.s.){ub{K63}(n)} (decrease of ubiquitination)
A20(h) --> RIP(m.s.){ub{K48}(n)} (increase of ubiquitination)
A20(h) + TRAF6(m) <==> A20(h):TRAF6(m) (binding)
A20(h) --/ TNFAIP3(h) (transrepression)
A20(h) --> A20-p37(h) + A20-p50(h) (cleavage)
A20(h) --> A20-p50(h) + protein remnants (cleavage)
A20(h) --/ TRAF2-isoform1(m) (decrease of abundance)
RIP(m.s.) + A20(h) <==> RIP(m.s.):A20(h) (binding)
A20(h) + TRAF6(m.s.) <==> A20(h):TRAF6(m.s.) (binding)
TNFAIP3(h) --> A20(h) (expression).
RIP(m.s.){ub}n --A20(h)--> RIP(m.s.) + n ubiquitin(m.s.) (deubiquitination)
TRAF6(m.s.){ub{K63}(n)} --A20(h)--> TRAF6(m.s.) + ubiquitin(m.s.) (deubiquitination)
TRAF6(m){ub}n --A20(h)--> TRAF6(m) + n ubiquitin(m) (deubiquitination)
ubiquitin(h){ub{K48}(6)} --A20(h)--> ubiquitin(h){ub{K48}(5)} + ubiquitin(h) (deubiquitination)
ubiquitin(h){ub{K48}(5)} --A20(h)--> ubiquitin(h){ub{K48}(4)} + ubiquitin(h) (deubiquitination)
ubiquitin(h){ub{K48}(4)} --A20(h)--> ubiquitin(h){ub{K48}(3)} + ubiquitin(h) (deubiquitination)
ubiquitin(h){ub{K48}(3)} --A20(h)--> ubiquitin(h){ub{K48}(2)} + ubiquitin(h) (deubiquitination)
ubiquitin(h){ub{K48}(2)} --A20(h)--> ubiquitin(h){ub{K48}(1)} + ubiquitin(h) (deubiquitination)
ubiquitin(h){ub{K63}(4)} --A20(h)--> ubiquitin(h){ub{K63}(3)} + ubiquitin(h) (deubiquitination)
ubiquitin(h){ub{K63}(3)} --A20(h)--> ubiquitin(h){ub{K63}(2)} + ubiquitin(h) (deubiquitination)
ubiquitin(h){ub{K63}(2)} --A20(h)--> ubiquitin(h){ub{K63}(1)} + ubiquitin(h) (deubiquitination)

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

575Phosphoserine.Swiss-Prot 53.0
568Phosphoserine17081983Phospho.ELM 6.0
575Phosphoserine17081983Phospho.ELM 6.0
645Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr6

Promoter: 138228774 - 138230774Agilent_014791

chr6

Promoter: 138228774 - 138230774GSE27584

chr6

Promoter: 138228774 - 138230774Agilent_014791_44K

chr6

Promoter: 138228774 - 138230774Agilent_014791


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