ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ADA

Full Name:

adenosine deaminase

Organism:

Homo sapiens (Human)

Chromosome:

20

Genetic Location:

20q12-q13.11

Physical Location:

42681576-42713789 on NC_000020.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ADA

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D20S119

43082264

Region:		41082264-45082264
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000022.2	NP_000013.2	NC_000020.9 range: 42681576..42713789, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005764	lysosome	Cellular Component	IDA (8452534)
GO:0005829	cytosol	Cellular Component	EXP (3182793)
GO:0016020	membrane	Cellular Component	IDA (11999881)
GO:0009897	external side of plasma membrane	Cellular Component	IDA (7759315\|16670267)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0004000	adenosine deaminase activity	Molecular Function	EXP (3182793)
GO:0004000	adenosine deaminase activity	Molecular Function	IDA (3182793\|8452534\|9361033\|11999881\|16670267)
GO:0005515	protein binding	Molecular Function	IPI (7594462\|14684150)
GO:0008270	zinc ion binding	Molecular Function	IMP (7599635)
GO:0033632	regulation of cell-cell adhesion mediated by integrin	Biological Process	IDA (11772392)
GO:0042110	T cell activation	Biological Process	IDA (7594462)
GO:0046103	inosine biosynthetic process	Biological Process	IDA (8894685)
GO:0001666	response to hypoxia	Biological Process	IDA (16670267)
GO:0032261	purine nucleotide salvage	Biological Process	IMP (9361033)
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	Biological Process	IEA
GO:0009117	nucleotide metabolic process	Biological Process	IEA
GO:0006154	adenosine catabolic process	Biological Process	IDA (16670267)
GO:0060169	negative regulation of adenosine receptor signaling pathway	Biological Process	IDA (16670267)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000196839

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: