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Gene Information
Gene ID:100
Full Name:adenosine deaminase
Organism:Homo sapiens (Human)
Genetic Location:20q12-q13.11
Physical Location:42681576-42713789 on NC_000020.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ADA
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D20S119  43082264
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000022.2NP_000013.2NC_000020.9 range: 42681576..42713789, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005764lysosomeCellular ComponentIDA (8452534)
GO:0005829cytosolCellular ComponentEXP (3182793)
GO:0016020membraneCellular ComponentIDA (11999881)
GO:0009897external side of plasma membraneCellular ComponentIDA (7759315|16670267)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0004000adenosine deaminase activityMolecular FunctionEXP (3182793)
GO:0004000adenosine deaminase activityMolecular FunctionIDA (3182793|8452534|9361033|11999881|16670267)
GO:0005515protein bindingMolecular FunctionIPI (7594462|14684150)
GO:0008270zinc ion bindingMolecular FunctionIMP (7599635)
GO:0033632regulation of cell-cell adhesion mediated by integrinBiological ProcessIDA (11772392)
GO:0042110T cell activationBiological ProcessIDA (7594462)
GO:0046103inosine biosynthetic processBiological ProcessIDA (8894685)
GO:0001666response to hypoxiaBiological ProcessIDA (16670267)
GO:0032261purine nucleotide salvageBiological ProcessIMP (9361033)
GO:0009168purine ribonucleoside monophosphate biosynthetic processBiological ProcessIEA
GO:0009117nucleotide metabolic processBiological ProcessIEA
GO:0006154adenosine catabolic processBiological ProcessIDA (16670267)
GO:0060169negative regulation of adenosine receptor signaling pathwayBiological ProcessIDA (16670267)
Other Database Cross Links
NCBI Entrez Gene:100
HuGE Navigator:100