ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC25A15

Full Name:

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

Alias:

D13S327|HHH|ORC1|ORNT1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

13q14

Physical Location:

40261596-40282245 on NC_000013.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S171

32151912

Region:		32151912-40979230
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014252.2	NP_055067.1	NC_000013.9 range: 40261596..40282245

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	TAS (10369256)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	TAS (10369256)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	IEA
GO:0000064	L-ornithine transmembrane transporter activity	Molecular Function	TAS (10369256)
GO:0006520	amino acid metabolic process	Biological Process	TAS (10369256)
GO:0006810	transport	Biological Process	IEA
GO:0000066	mitochondrial ornithine transport	Biological Process	TAS (10369256)
GO:0000050	urea cycle	Biological Process	TAS (10369256)