ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

THOC4

Full Name:

THO complex 4

Alias:

ALY|BEF

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25.3

Physical Location:

77439015-77442757 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 44029 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005782.2	NP_005773.2	NC_000017.9 range: 77439015..77442757, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005681	spliceosome	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15047853)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	EXP (12226669)
GO:0006810	transport	Biological Process	IEA
GO:0008380	RNA splicing	Biological Process	IEA
GO:0051028	mRNA transport	Biological Process	IEA