ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LANCL1

Full Name:

LanC lantibiotic synthetase component C-like 1 (bacterial)

Alias:

GPR69A|p40

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33-q35

Physical Location:

211004219-211049675 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006055.1	NP_006046.1	NC_000002.10 range: 211004219..211049675, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9512664)
GO:0016020	membrane	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS (9512664)
GO:0050750	low-density lipoprotein receptor binding	Molecular Function	IDA (15082773)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (9512664)