ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TLR6

Full Name:

toll-like receptor 6

Alias:

CD286

Organism:

Homo sapiens (Human)

Chromosome:

4

Genetic Location:

4p14

Physical Location:

38504802-38507554 on NC_000004.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TLR6

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006068.2	NP_006059.2	NC_000004.10 range: 38504802..38507554, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	EXP (14625308\|16024789)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (10231569)
GO:0031224	intrinsic to membrane	Cellular Component	IEA
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0008034	lipoprotein binding	Molecular Function	ISS (11431423)
GO:0005515	protein binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	TAS (10231569)
GO:0045087	innate immune response	Biological Process	IEA
GO:0043507	positive regulation of JNK activity	Biological Process	IDA (10231569)
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IDA (10231569)
GO:0042742	defense response to bacterium	Biological Process	TAS (10426995)
GO:0042088	T-helper 1 type immune response	Biological Process	IC (11686851)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007250	activation of NF-kappaB-inducing kinase activity	Biological Process	NAS (10231569)
GO:0045410	positive regulation of interleukin-6 biosynthetic process	Biological Process	ISS (12077222)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000174130

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: