ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ADARB2

Full Name:

adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)

Alias:

ADAR3|FLJ25034|FLJ36975|RED2|hRED2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10p15.3

Physical Location:

1218072-1769669 on NC_000010.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D10S249

270791

Region:		1-2270791
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018702.2	NP_061172.1	NC_000010.9 range: 1218072..1769669, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0004000	adenosine deaminase activity	Molecular Function	TAS (10836796)
GO:0004000	adenosine deaminase activity	Molecular Function	IEA
GO:0003727	single-stranded RNA binding	Molecular Function	TAS (10836796)
GO:0003725	double-stranded RNA binding	Molecular Function	TAS (10836796)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006396	RNA processing	Biological Process	IEA
GO:0006397	mRNA processing	Biological Process	IEA