ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FARS2

Full Name:

phenylalanyl-tRNA synthetase 2, mitochondrial

Alias:

FARS1|HSPC320|PheRS|dJ520B18.2

Organism:

Homo sapiens (Human)

Chromosome:

6

Genetic Location:

6p25.1

Physical Location:

5206582-5716814 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D6S1574

5957132

Region:		3957132-7957132
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006567.3	NP_006558.1	NC_000006.10 range: 5206582..5716814

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005625	soluble fraction	Cellular Component	IDA (10329163)
GO:0000049	tRNA binding	Molecular Function	IDA (10329163)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004826	phenylalanine-tRNA ligase activity	Molecular Function	IEA
GO:0004826	phenylalanine-tRNA ligase activity	Molecular Function	IDA (10329163)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0006412	translation	Biological Process	IEA
GO:0006432	phenylalanyl-tRNA aminoacylation	Biological Process	IDA (10329163)
GO:0006432	phenylalanyl-tRNA aminoacylation	Biological Process	IEA
GO:0008033	tRNA processing	Biological Process	IDA (10329163)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000145982

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: