ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TNFSF13B

Full Name:

tumor necrosis factor (ligand) superfamily, member 13b

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

13q32-q34

Physical Location:

107719977-107757365 on NC_000013.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S1265

108126458

Region:		106126458-110126458
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006573.3	NP_006564.1	NC_000013.9 range: 107719977..107757365

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NR
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0005625	soluble fraction	Cellular Component	TAS (10908663)
GO:0005125	cytokine activity	Molecular Function	IEA
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (10908663)
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS (10359578)