| Gene Information |
| Gene ID: | | 10715 |
| Symbol: | | LASS1 |
| Full Name: | | LAG1 homolog, ceramide synthase 1 |
| Alias: | | CerS1|LAG1|MGC90349|UOG1 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 19 |
| Genetic Location: | | 19p12 |
| Physical Location: | | 18842116-18867952 on NC_000019.8, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AI936592 | | Fold Change: | | -1.4, -1.5 | | Note: | | Differential Expression on the cDNA array (two fold changes are from two case groups) |
| | Dataset Information | | Name: | | 11141048 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed | | Summary: | | RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IEA | |
| GO:0005789 | endoplasmic reticulum membrane | Cellular Component | IEA | |
| GO:0005792 | microsome | Cellular Component | ISS | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0003674 | molecular_function | Molecular Function | ND | |
| GO:0050291 | sphingosine N-acyltransferase activity | Molecular Function | ISS | |
| GO:0008610 | lipid biosynthetic process | Biological Process | IEA | |
| GO:0046513 | ceramide biosynthetic process | Biological Process | ISS | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 10715 |
| HGNC: | | 14253 |
| Ensembl: | | |
| MIM: | | 606919 |
| HPRD: | | 12114 |
| HuGE Navigator: | | 10715 |
| dbSNP: | | LASS1 |
| GeneCard: | | LASS1 |
| AceView: | | LASS1 |
