ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NRG3

Full Name:

neuregulin 3

Alias:

HRG3|pro-NRG3

Organism:

Homo sapiens (Human)

Chromosome:

10

Genetic Location:

10q22-q23

Physical Location:

83625076-84735340 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene SNP Information

SNP	Abuser/Control Ratio	Cluster
rs7069222 dbSNP	1.23	39
rs4298845 dbSNP	1.24	40

Association Dataset

Name:		16894614
Method:		Association
Publication:		Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:		Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001010848.2	NP_001010848.2	NC_000010.9 range: 83625076..84735340

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	NAS (9275162)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NAS (9275162)
GO:0008083	growth factor activity	Molecular Function	NAS (9275162)
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Molecular Function	NAS (9275162)
GO:0030971	receptor tyrosine kinase binding	Molecular Function	NAS (9275162)
GO:0001558	regulation of cell growth	Biological Process	NAS (9275162)
GO:0009790	embryonic development	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000185737

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: